EGFR
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- AZ5104, Inhibitor of epidermal growth factor receptorCAS: 1421373-98-9 Formula: C27H31N7O2 Molecular Weight: 485.58Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A421560View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide
- SMILES
- CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC
- InChIKey
- IQNVEOMHJHBNHC-UHFFFAOYSA-N
- InChI
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- Synonyms
- 2-Propenamide, N-(2-((2-(dimethylamino)ethyl)methylamino)-5-((4-(1H-indol-3-yl)-2-pyrimidinyl)amino)-4-methoxyphenyl)...
- AZD-9291 mesylate, Epidermal growth factor receptor erbB1 inhibitor10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A421559View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid
- SMILES
- CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.CS(=O)(=O)O
- InChIKey
- FUKSNUHSJBTCFJ-UHFFFAOYSA-N
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- N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-pro...
- AZD3759, Epidermal growth factor receptor erbB1 inhibitorCAS: 1626387-80-1 Formula: C22H23ClFN5O3 Molecular Weight: 459.9Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%● In Stock — US warehouse, ships to EU* Item #: A413895View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- [4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl] (2R)-2,4-dimethylpiperazine-1-carboxylate
- SMILES
- CC1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C
- InChIKey
- MXDSJQHFFDGFDK-CYBMUJFWSA-N
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- (R)-4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate | EX-A720 | zorife...
- AZD3759, Epidermal growth factor receptor erbB1 inhibitorCAS: 1626387-80-1 Formula: C22H23ClFN5O3 Molecular Weight: 459.9Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO◐ .Made to order · 8–12 wks Item #: A421980View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- [4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl] (2R)-2,4-dimethylpiperazine-1-carboxylate
- SMILES
- CC1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C
- InChIKey
- MXDSJQHFFDGFDK-CYBMUJFWSA-N
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- Synonyms
- (R)-4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate | EX-A720 | zorife...
- AfatinibCAS: 439081-18-2 Formula: C24H25ClFN5O3 Molecular Weight: 485.9410mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A423984View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
- SMILES
- CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
- InChIKey
- ULXXDDBFHOBEHA-CWDCEQMOSA-N
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- Synonyms
- BIBW2992 | (2E)-N-(4-(3-chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-en...
- Afatinib dimaleate, Receptor protein-tyrosine kinase erbB-4 inhibitorCAS: 850140-73-7 EC Number: 810-416-1 PubChem CID: 15606394 Formula: C32H33ClFN5O11 Molecular Weight: 718.0810mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A426249View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (Z)-but-2-enedioic acid;(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
- SMILES
- CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
- InChIKey
- USNRYVNRPYXCSP-JUGPPOIOSA-N
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- BIBW2992 DiMaleate | (2E)-N-(4-[(3-chloro-4-fluorophenyl)amino]-7-{[(3S)-tetrahydrofuran-3-yl]oxy}quinazolin-6-yl)-4-...
- AfatinibCAS: 439081-18-2 Formula: C24H25ClFN5O3 Molecular Weight: 485.94Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: A401422View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
- SMILES
- CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
- InChIKey
- ULXXDDBFHOBEHA-CWDCEQMOSA-N
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- Synonyms
- (2E)-N-(4-(3-chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-enamide | AFA...
- Alflutinib (AST2818) mesylate● In Stock — US warehouse, ships to EU* Item #: A413662View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
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- SMILES
- CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(N=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OCC(F)(F)F.CS(=O)(=O)O
- InChIKey
- WDPGHXINXNBHAS-UHFFFAOYSA-N
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- C29H35F3N8O5S | EX-A2864 | 2130958-55-1 | Furmonertinib mesylate | ALFLUTINIB MESILATE | AC-35567 | Alflutinib mesyla...
- Alflutinib (AST2818) mesylate10mM in DMSO● In Stock — US warehouse, ships to EU* Item #: A422285View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
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- SMILES
- CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(N=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OCC(F)(F)F.CS(=O)(=O)O
- InChIKey
- WDPGHXINXNBHAS-UHFFFAOYSA-N
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- Synonyms
- C29H35F3N8O5S | EX-A2864 | 2130958-55-1 | Furmonertinib mesylate | ALFLUTINIB MESILATE | AC-35567 | Alflutinib mesyla...
- Avitinib (AC0010), Epidermal growth factor receptor erbB1 inhibitorCAS: 1557267-42-1 Formula: C26H26FN7O2 Molecular Weight: 487.53Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO◐ .Made to order · 8–12 wks Item #: A421854View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[3-[[2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide
- SMILES
- CN1CCN(CC1)C2=C(C=C(C=C2)NC3=NC4=C(C=CN4)C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)F
- InChIKey
- UOFYSRZSLXWIQB-UHFFFAOYSA-N
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- Synonyms
- 1557267-42-1 | ACEA100610 | BCP16381 | Abivertinib | GTPL10044 | ABIVERTINIB [INN] | N-(3-((2-((3-Fluoro-4-(4-methylp...
- Avitinib (AC0010), Epidermal growth factor receptor erbB1 inhibitorCAS: 1557267-42-1 Formula: C26H26FN7O2 Molecular Weight: 487.53Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%● In Stock — US warehouse, ships to EU* Item #: A414148View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[3-[[2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide
- SMILES
- CN1CCN(CC1)C2=C(C=C(C=C2)NC3=NC4=C(C=CN4)C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)F
- InChIKey
- UOFYSRZSLXWIQB-UHFFFAOYSA-N
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- Synonyms
- 1557267-42-1 | ACEA100610 | BCP16381 | Abivertinib | GTPL10044 | ABIVERTINIB [INN] | N-(3-((2-((3-Fluoro-4-(4-methylp...
- BI-4020CAS: 2664214-60-0 Formula: C30H38N8O2 Molecular Weight: 542.68◐ .Made to order · 8–12 wks Item #: B414270View ProductPricing & Pack Sizes
Technical Identifiers
- Synonyms
- (R,E)-11,26,7-trimethyl-56-((4-methylpiperazin-1-yl)methyl)-52,53-dihydro-11H,51H-11-oxa-4-aza-5(2,1)-benzo[d]imidazo...
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Frequently Asked Questions
How is the EGFR listing put together?
It draws on reported EGFR annotations within JAK/STAT Signaling and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose an EGFR modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the EGFR entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for EGFR compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For EGFR work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the EGFR compound I need is not listed?
Search by CAS number or SMILES first, since analogs of EGFR compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.












