EGFR
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- BI-1622CAS: 2681392-19-6 Formula: C26H24N10O2 Molecular Weight: 508.53◐ .Made to order · 8–12 wks Item #: B649337View ProductPricing & Pack Sizes
Technical Identifiers
- Avitinib maleateCAS: 1557268-88-8 Formula: C30H30FN7O6 Molecular Weight: 603.60◐ .Made to order · 8–12 wks Item #: A650397View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- (Z)-but-2-enedioic acid;N-[3-[[2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide
- SMILES
- CN1CCN(CC1)C2=C(C=C(C=C2)NC3=NC4=C(C=CN4)C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)F.C(=CC(=O)O)C(=O)O
- InChIKey
- VRHPZWLHPIENFW-BTJKTKAUSA-N
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- Synonyms
- Abivertinib maleate anhydrous | A901932 | HY-19816A | 2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)ph...
- MS9427CAS: 2772613-37-1 Formula: C48H58ClFN8O12 Molecular Weight: 993.47◐ .Made to order · 8–12 wks Item #: M650356View ProductPricing & Pack Sizes
Technical Identifiers
- Osimertinib dimesylate◐ .Made to order · 8–12 wks Item #: O650598View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid
- SMILES
- CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.CS(=O)(=O)O.CS(=O)(=O)O
- InChIKey
- RPUCCTLBBCSFEX-UHFFFAOYSA-N
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- Rezivertinib◐ .Made to order · 8–12 wks Item #: R650600View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[2-[2-(dimethylamino)ethoxy]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
- SMILES
- CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=CC(=C(C=C4OC)OCCN(C)C)NC(=O)C=C
- InChIKey
- BPMZUKYFIDPLEA-UHFFFAOYSA-N
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- Synonyms
- 2-Propenamide, N-(2-(2-(dimethylamino)ethoxy)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)phenyl)- |...
- Almonertinib hydrochloride◐ .Made to order · 8–12 wks Item #: A650866View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-[5-[[4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide;hydrochloride
- SMILES
- CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC.Cl
- InChIKey
- CUXBWKDZKQGJNN-UHFFFAOYSA-N
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- limertinibCAS: 1934259-00-3 Formula: C29H32ClN7O2 Molecular Weight: 546.06◐ .Made to order · 8–12 wks Item #: L651246View ProductPricing & Pack Sizes
Technical Identifiers
- SMILES
- O=C(NC1=CC(NC2=NC=C(C(NC3=CC4=C(C=CC=C4)C=C3)=N2)Cl)=C(C=C1N(CCN(C)C)C)OC)C=C
- CCT365623 hydrochloride◐ .Made to order · 8–12 wks Item #: C651445View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- [5-(3-methylsulfonyl-5-phenylphenyl)sulfonylthiophen-2-yl]methanamine;hydrochloride
- SMILES
- CS(=O)(=O)C1=CC(=CC(=C1)C2=CC=CC=C2)S(=O)(=O)C3=CC=C(S3)CN.Cl
- InChIKey
- MKBRQENFVVWIGU-UHFFFAOYSA-N
- InChI
- 1S/C18H17NO4S3.ClH/c1-25(20,21)16-9-14(13-5-3-2-4-6-13)10-17(11-16)26(22,23)18-8-7-15(12-19)24-18;/h2-11H,12,19H2,1H3;1H
- Mutated EGFR-IN-1◐ .Made to order · 8–12 wks Item #: M651981View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- 1-N-[2-(dimethylamino)ethyl]-5-methoxy-1-N-methyl-4-N-[4-(1-methylindol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine
- SMILES
- CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)N)N(C)CCN(C)C)OC
- InChIKey
- HTNTZPBKKCORTP-UHFFFAOYSA-N
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- Mobocertinib succinate, Epidermal growth factor receptor erbB1 inhibitor◐ .Made to order · 8–12 wks Item #: M651984View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
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- SMILES
- CC(C)OC(=O)C1=CN=C(N=C1C2=CN(C3=CC=CC=C32)C)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC.C(CC(=O)O)C(=O)O
- InChIKey
- YXYAEUMTJQGKHS-UHFFFAOYSA-N
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- Synonyms
- AP32788 succinate | AP-32788 succinate | butanedioic acid;propan-2-yl 2-[4-[2-(dimethylamino)ethyl-methylamino]-2-met...
- Gefitinib-d8CAS: 857091-32-8 Formula: C22H16D8ClFN4O3 Molecular Weight: 454.95◐ .Made to order · 8–12 wks Item #: G646578View ProductPricing & Pack Sizes
Technical Identifiers
- IUPAC Name
- N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)propoxy]quinazolin-4-amine
- SMILES
- COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
- InChIKey
- XGALLCVXEZPNRQ-IHGLQNJRSA-N
- InChI
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- Synonyms
- AKOS040733242 | DTXSID60678648 | HY-50895S | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(2,2,3,3,5,5,6,6-octadeuterio...
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Frequently Asked Questions
How is the EGFR listing put together?
It draws on reported EGFR annotations within JAK/STAT Signaling and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose an EGFR modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the EGFR entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for EGFR compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For EGFR work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the EGFR compound I need is not listed?
Search by CAS number or SMILES first, since analogs of EGFR compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.