drug screening

Diabetes mellitus is a chronic metabolic disease caused by insufficient insulin secretion, insulin resistance, or a combination of both. Natural products possess diverse structural classes and multiple biological targets and can be used in studies of glucose-metabolism regulation, bioactive ...

Tumor organoids can retain some of the histological features, driver alterations, and clonal differences of a patient’s tumor, providing expandable human-derived models for studying tumor evolution, therapeutic sensitivity, and mechanisms of drug resistance.

Organoids can self-organize from tissue stem cells, primary cells, or pluripotent stem cells in a three-dimensional environment and partially reconstruct the cellular composition, spatial architecture, and functional characteristics of organs. They provide models that more closely resemble in ...