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224,000+ research products · Triple ISO certified · COA & SDS available for every product · Same-day shipping on in-stock items

PROTAC Linkers

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  2. Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride
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    Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride
    CAS: 174422-72-1 PubChem CID: 16737821 Formula: C12H18ClN3O3 Molecular Weight: 287.74
    Solid ≥98%
    ◐ .Made to order · 8–12 wks Item #: M777655
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    Technical Identifiers
    IUPAC Name
    4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carbohydrazide;hydrochloride
    SMILES
    C1CC(CCC1CN2C(=O)C=CC2=O)C(=O)NN.Cl
    InChIKey
    CKGAFBJFAXITJV-UHFFFAOYSA-N
    InChI
    1S/C12H17N3O3.ClH/c13-14-12(18)9-3-1-8(2-4-9)7-15-10(16)5-6-11(15)17;/h5-6,8-9H,1-4,7,13H2,(H,14,18);1H
  4. ST7612AA1
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    ST7612AA1
    CAS: 1428535-92-5 Formula: C20H27N3O4S Molecular Weight: 405.51
    ◐ .Made to order · 8–12 wks Item #: S777665
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    Technical Identifiers
    IUPAC Name
    S-[(6S)-7-anilino-7-oxo-6-[[(2R)-5-oxopyrrolidine-2-carbonyl]amino]heptyl] ethanethioate
    SMILES
    CC(=O)SCCCCCC(C(=O)NC1=CC=CC=C1)NC(=O)C2CCC(=O)N2
    InChIKey
    QGYPCQAYENIOOF-DLBZAZTESA-N
    InChI
    1S/C20H27N3O4S/c1-14(24)28-13-7-3-6-10-16(19(26)21-15-8-4-2-5-9-15)23-20(27)17-11-12-18(25)22-17/h2,4-5,8-9,16-17H,3,6-7,10-13H2,1H3,(H,21,26)(H,22,25show more
  7. Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal
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    Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal
    CAS: 2345732-83-2 Formula: C46H50N3O15P Molecular Weight: 915.87
    ◐ .Made to order · 8–12 wks Item #: G778088
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    Technical Identifiers
    IUPAC Name
    (4S)-4-[[2-(2,5-dioxopyrrol-1-yl)acetyl]amino]-5-[3-[[4-[(1S,2S,4R,6R,8S,9S,11S,12S,13R)-11-hydroxy-9,13-dimethyl-16-oxo-8-(2-phosphonooxyacetyl)-5,7-show more
    SMILES
    C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(O[C@@H](O4)C5=CC=C(C=C5)CC6=CC(=CC=C6)NC(=O)[C@H](CCC(=O)O)NC(=O)CN7C(=O)C=CC7=O)C(=O)COP(=O)(O)O)CCC8show more
    InChIKey
    BACFCSKNRKGXJF-YFTVFXHHSA-N
    InChI
    1S/C46H50N3O15P/c1-44-17-16-30(50)20-28(44)10-11-31-32-21-36-46(35(52)24-62-65(59,60)61,45(32,2)22-34(51)41(31)44)64-43(63-36)27-8-6-25(7-9-27)18-26-4show more
  8. PH-HG-005-5
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    PH-HG-005-5
    CAS: 2810895-93-1 Formula: C41H47N7O10 Molecular Weight: 797.85
    ≥99%
    ◐ .Made to order · 8–12 wks Item #: P777997
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    [4-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoyl]amino]phenyl]methyl [(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3show more
    SMILES
    CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)OC(=O)OCC5=CC=C(C=C5)NC(=O)[C@H](CCCNC(=O)N)NC(=O)[C@H](C(C)C)N)C2=NC6=C1C=C(C=C6)O
    InChIKey
    QTKSYHWJQGUBIT-XWFQJVGVSA-N
    InChI
    1S/C41H47N7O10/c1-5-25-26-16-24(49)13-14-30(26)46-34-27(25)18-48-32(34)17-29-28(37(48)52)20-56-38(53)41(29,6-2)58-40(55)57-19-22-9-11-23(12-10-22)45-3show more
  12. NHS-MMAF
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    NHS-MMAF
    CAS: 1404073-19-3 Formula: C49H78N6O12 Molecular Weight: 943.18
    ≥97%
    ◐ .Made to order · 8–12 wks Item #: N777938
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    (2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[[6-(2,5-dioxopyrrolidin-1-yl)oxy-6-oxohexyl]-methylamino]-3-methylbutanoyl]amino]-3-methylshow more
    SMILES
    CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)CCCCCC(=O)Oshow more
    InChIKey
    HANHTXBATRQQFL-YTVPMEHESA-N
    InChI
    1S/C49H78N6O12/c1-12-32(6)44(37(65-10)29-40(58)54-27-19-22-36(54)45(66-11)33(7)46(60)50-35(49(63)64)28-34-20-15-13-16-21-34)53(9)48(62)42(30(2)3)51-47show more
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Frequently Asked Questions

What should I consider when selecting PROTAC Linkers?
When selecting PROTAC Linkers, consider the coupling chemistry available on both partners, whether the linker needs to be cleavable, and how length and hydrophilicity will affect solubility of the final conjugate. Test a short series rather than committing to one geometry.
What does PROTAC Linkers cover?
PROTAC Linkers is a top-level listing in our catalogue. Use the filters and search on the listing page to narrow by the attributes that matter for your work, or browse the neighbouring categories from the main navigation.
Which quality data should I check for PROTAC Linkers?
Review HPLC purity and MS identity for the PROTAC Linkers lot and, where relevant, the polydispersity index, plus residual solvent and water content. For reactive esters and similar handles, the retest date matters as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I find PROTAC Linkers by reactive group or linker length?
Yes — filter PROTAC Linkers by reactive handle, linker length or PEG units, and cleavability, and search by CAS number or SMILES for exact structures. Custom linkers and bulk quantities: [email protected].
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