PROTAC Linkers

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  1. DBCO-PEG4-Ahx-DM1
    CAS: 2479378-44-2 Formula: C68H89ClN6O17 Molecular Weight: 1297.92
    ◐ .Made to order · 8–12 wks Item #: D777918
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    Technical Identifiers
    IUPAC Name
    [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.0show more
    SMILES
    C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCCCCNC(=O)CCOCCOCCOCCOCCNC(=O)CCC(show more
    InChIKey
    HAGWYLKCEZXKPL-JKNPZXPHSA-N
    InChI
    1S/C68H89ClN6O17/c1-45-17-16-22-56(85-8)68(83)43-55(90-66(82)72-68)46(2)64-67(4,92-64)57(42-62(80)74(6)53-40-48(39-45)41-54(84-7)63(53)69)91-65(81)47(show more
  2. SC-VC-PAB-DM1
    CAS: 2259318-47-1 Formula: C61H82ClN9O19 Molecular Weight: 1280.81
    ◐ .Made to order · 8–12 wks Item #: S777900
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    IUPAC Name
    (2,5-dioxopyrrolidin-1-yl) 6-[[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-[[[(2S)-1-[[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxyshow more
    SMILES
    C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)OCC5=CC=C(C=C5)NC(=O)[C@H](CCCNC(=Oshow more
    InChIKey
    LXJMPVKQZDSAAC-OGMVYAKQSA-N
    InChI
    1S/C61H82ClN9O19/c1-33(2)52(67-46(72)18-11-12-19-50(76)90-71-47(73)24-25-48(71)74)55(78)66-40(16-14-26-64-57(63)80)54(77)65-39-22-20-37(21-23-39)32-86show more
  3. Lys-Nε-SPDB-DM4
    CAS: 1280215-91-9 Formula: C48H72ClN5O13S2 Molecular Weight: 1026.69
    ◐ .Made to order · 8–12 wks Item #: L777895
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    Technical Identifiers
    IUPAC Name
    (2S)-2-amino-6-[4-[[5-[[(2S)-1-[[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22show more
    SMILES
    C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)SSCCCC(=O)NCCCC[C@@H](C(=Oshow more
    InChIKey
    VUAUZOXSQKWNNO-NBSRGMMNSA-N
    InChI
    1S/C48H72ClN5O13S2/c1-28-15-13-17-36(64-10)48(62)27-35(65-45(61)52-48)29(2)42-47(6,67-42)37(26-40(57)54(8)33-24-31(23-28)25-34(63-9)41(33)49)66-44(60)show more
  4. Cyclooctyne-O-amido-PEG4-VC-PAB-Gly-Gly-NH-O-CO-Exatecan
    CAS: 2699066-62-9 Formula: C69H90FN11O19 Molecular Weight: 1396.51
    ◐ .Made to order · 8–12 wks Item #: C777804
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    Technical Identifiers
    IUPAC Name
    [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[3-[2-[2-[2-[2-[(2-cyclooct-2-yn-1-yloxyacetyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-methylbutanshow more
    SMILES
    CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C5[C@H](CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)NC(=O)COCNC(=O)CNC(=O)OCC7=CC=C(C=C7)NC(=O)[C@H](CCCNC(=O)N)NC(=O)[C@H](C(C)C)NCshow more
    InChIKey
    QODUAYOFZUVKPU-HPLXPLKLSA-N
    InChI
    1S/C69H90FN11O19/c1-5-69(92)49-32-54-62-47(35-81(54)65(88)48(49)37-99-66(69)89)60-51(20-19-46-42(4)50(70)33-53(78-62)59(46)60)77-58(85)38-97-40-75-56(show more
  5. Val-Cit-amide-Cbz-N(Me)-Maytansine
    CAS: 1628543-59-8 Formula: C55H78ClN9O15 Molecular Weight: 1140.71
    ◐ .Made to order · 8–12 wks Item #: V778023
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    Technical Identifiers
    IUPAC Name
    [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.0show more
    SMILES
    C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCN(C)C(=O)OCC5=CC=C(C=C5)NC(=O)[C@show more
    InChIKey
    WHRVZTYLCHEVBV-HIIFFYOTSA-N
    InChI
    1S/C55H78ClN9O15/c1-30(2)46(57)49(69)61-37(15-13-22-59-51(58)71)48(68)60-36-19-17-34(18-20-36)29-77-53(73)63(7)23-21-43(66)64(8)33(5)50(70)79-42-27-44show more
  6. MC-Val-Cit-PAB-clindamycin
    CAS: 1639793-13-7 Formula: C46H72Cl2N8O11S Molecular Weight: 1016.08
    ◐ .Made to order · 8–12 wks Item #: M777807
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    (2S,4R)-1-[[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl]-N-[(1show more
    SMILES
    CCC[C@@H]1C[C@H]([N+](C1)(C)CC2=CC=C(C=C2)NC(=O)[C@H](CCCNC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)CCCCCN3C(=O)C=CC3=O)C(=O)N[C@@H]([C@@H]4[C@@H]([C@@H]([C@H]([show more
    InChIKey
    KINAEBJVJLCQDX-DCAHZPCSSA-O
    InChI
    1S/C46H71ClN8O11S/c1-7-12-29-23-32(43(63)53-37(27(4)47)41-39(60)38(59)40(61)45(66-41)67-6)55(5,25-29)24-28-15-17-30(18-16-28)50-42(62)31(13-11-21-49-4show more
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

What should I consider when selecting PROTAC Linkers?
When selecting PROTAC Linkers, consider the coupling chemistry available on both partners, whether the linker needs to be cleavable, and how length and hydrophilicity will affect solubility of the final conjugate. Test a short series rather than committing to one geometry.
What does PROTAC Linkers cover?
PROTAC Linkers is a top-level listing in our catalogue. Use the filters and search on the listing page to narrow by the attributes that matter for your work, or browse the neighbouring categories from the main navigation.
Which quality data should I check for PROTAC Linkers?
Review HPLC purity and MS identity for the PROTAC Linkers lot and, where relevant, the polydispersity index, plus residual solvent and water content. For reactive esters and similar handles, the retest date matters as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I find PROTAC Linkers by reactive group or linker length?
Yes — filter PROTAC Linkers by reactive handle, linker length or PEG units, and cleavability, and search by CAS number or SMILES for exact structures. Custom linkers and bulk quantities: [email protected].

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