Purmorphamine - Moligand™, ≥98% , Agonist of SMO, CAS No.483367-10-8, Agonist of SMO
In stock
SKU
P126030
Smoothened receptor agonist
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
An activator of the hedgehog (Hh) signaling pathway.
More Information
| CAS | 483367-10-8 |
|---|---|
| Synonyms | Shh Signaling Antagonist VI | 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine |
| Specifications & Purity | Moligand™, ≥98% |
| Storage | Store at -20°C,Argon charged |
| Shipped In | Ice chest + Ice pads |
| Product Description | Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM. |
| Pubchem Sid | 504763480 |
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504763480 |
| Solubility | Soluble in DMSO (10 mM), DMF (~20 mg/ml), DMF:PBS(pH 7.2) (1:1) (~0.25 mg/ml), and chloroform. |
| Sensitivity | 对空气敏感;对热敏感 |
| Target | SMO |
| EC Number | 998-820-5 |
| PubChem CID | 5284329 |
| Molecular Formula | C31H32N6O2 |
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