MUC1 Mouse mAb - Anticuerpo primario, specific to MUC1, Mouse IgG1

Cat. No.: Ab116370

CALIDAD & PUREZA Carrier Free, ExactAb™, Azide Free, Validated, High Performance, See COA

Application

WB

Host species

Ratón

Reactive species

Humano

Isotype

Mouse IgG1

Clone Number

C1

Conjugation

Unconjugated

Descripción general

Mouse anti Human MUC1 antibody; , Monoclonal (C1), could be used for WB and so on.
Application:
WB: 0.01-2 µg/mL
Protein Function
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

Especificaciones

Product Name

MUC1 Mouse mAb - Anticuerpo primario, specific to MUC1, Mouse IgG1

Sinónimos

ADMCKD antibody | ADMCKD1 antibody | Breast carcinoma associated antigen DF3 antibody | Breast carcinoma-associated antigen DF3 antibody | CA 15-3 antibody | CA15 3 antibody | CA15 3 antigen antibody | CA15-3 antibody | CA15.3 antibody | Cancer antigen 15

Especificaciones y pureza

Carrier Free, ExactAb™, Azide Free, Validated, High Performance, See COA

Especies hospedadoras

Ratón

Especificidad

MUC1

Inmunógeno

Recombinant MUC1 expressed in E.coli (AA 1034~1151)

Control positivo

WB: Human milk.

Conjugación

Unconjugated

Grado

Azide Free, Carrier Free, ExactAb™, High Performance, Validated

Isotipo

Mouse IgG1

Tipo de cadena ligera

kappa

SDS-PAGE

150 kDa

Método de purificación

Protein A + Protein G affinity purified

Concentración

See COA

Product Line

Productos biológicos

Almacenamiento y envío

Forma

Liquid

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Avoid repeated freezing and thawing

Enviado en

Ice chest + Ice pads

Estabilidad y almacenamiento

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Imágenes

Western Blot: MUC1 Mouse mAb (Ab116370)

MUC1 Mouse mAb (Ab116370) - Western Blot
All lanes: MUC1 Mouse mAb (Ab116370) at 1/3000 dilution
Samples: Human milk
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/20000 dilution

Predicted band size: 25 kDa
Observed band size: 23,19 kDa
Exposure time: 10.0 s

Aplicación

Aplicación

Dilution info

WB

0.01-2 µg/mL

Objetivos asociados (humanos)

MUC1 Tchem Mucin-1 (0 Activities)

Discover Target: MUC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de acción

Preguntas frecuentes

How should this product be stored?

Store at ?20 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What does ExactAb? mean?

ExactAb? indicates the product has been validated for use in rigorous antibody validation workflows. Validation may include positive/negative control samples, signal-to-noise testing, and protocol-specific QC. Lot-specific test data is published on the Certificate of Analysis where available.

What does Carrier Free mean?

Carrier Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Which species reactivity has this antibody been validated against?

Validated reactivity is listed on the PDP and on each lot's datasheet. We validate against the most commonly tested species for the target (MUC1 Mouse mAb); cross-reactivity in untested species may exist but is not guaranteed. Contact technical support for specific species inquiries.