Semzuvolimab (anti-CD4) - Anticuerpo primario, specific to CD4, Human IgG1, INHIBITOR of T-cell surface antigen CD4 inhibitor, INHIBITOR of T-cell surface antigen CD4 inhibitor

CAS: 2409099-32-5 Cat. No.: Ab182802

CALIDAD & PUREZA Animal Free, Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Humano

Reactive species

Humano

Isotype

Human IgG1

Conjugation

Unconjugated

Descripción general

Semzuvolimab (anti-CD4) is a murine IgG1κ antibody, targeting to p55, T cell surface antigen T4/Leu-3 (CD4). Murine CD4 antibodies can neutralize HIV infection and have the potential to inhibit HAART stable HIV infection.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Especificaciones

Product Name

Semzuvolimab (anti-CD4) - Anticuerpo primario, specific to CD4, Human IgG1, INHIBITOR of T-cell surface antigen CD4 inhibitor

Sinónimos

CD 4 antibody | CD4 (L3T4) antibody | CD4 antibody | CD4 antigen (p55) antibody | CD4 antigen antibody | CD4 molecule antibody | CD4 receptor antibody | CD4+ Lymphocyte deficiency, included antibody | CD4_HUMAN antibody | CD4mut antibody | L3T4 antibody |

Especificaciones y pureza

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Especies hospedadoras

Humano

Especificidad

CD4

Conjugación

Unconjugated

Grado

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Tipo de acción

INHIBITOR

Mecanismo de acción

INHIBITOR of T-cell surface antigen CD4 inhibitor

Isotipo

Human IgG1

Tipo de cadena ligera

kappa

SDS-PAGE

27.4 kDa (Light Chain) & 53.6 kDa (Heavy Chain), under reducing conditions; 200.0 kDa, under non-reducing conditions.

Método de purificación

Protein A purified

Concentración

See COA

CAS

2409099-32-5

Product Line

Productos biológicos

Almacenamiento y envío

Forma

Liquid

Condiciones de almacenamiento de almacenamiento

Store at -80°C,Avoid repeated freezing and thawing

Enviado en

Dry ice packs + Cold packs

Estabilidad y almacenamiento

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Imágenes

Flow Cytometry: Semzuvolimab (anti-CD4) (Ab182802)

Semzuvolimab (anti-CD4) (Ab182802) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD4 with Semzuvolimab (anti-CD4) (Ab182802) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Semzuvolimab (anti-CD4) (Ab182802)

Semzuvolimab (anti-CD4) (Ab182802) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD4 (red) with Semzuvolimab (anti-CD4) (Ab182802) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Semzuvolimab (anti-CD4) (Ab182802)

Semzuvolimab (anti-CD4) (Ab182802) - Flow Cytometry
Flow Cytometry analysis of THP-1 cells labelling CD4 (red) with Semzuvolimab (anti-CD4) (Ab182802). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Semzuvolimab (anti-CD4) (Ab182802)

Semzuvolimab (anti-CD4) (Ab182802) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD4 (red) with Semzuvolimab (anti-CD4) (Ab182802). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: Semzuvolimab (anti-CD4) (Ab182802)

Semzuvolimab (anti-CD4) (Ab182802) - ELISA
Immobilized Recombinant Human CD4 protein (rp175911) at 1.0 μg/mL can bind Semzuvolimab (anti-CD4) (Ab182802) with the EC₅₀ of 54.16 ng/mL.

SEC: Semzuvolimab (anti-CD4) (Ab182802)

Semzuvolimab (anti-CD4) (Ab182802) - SEC
The purity of Semzuvolimab (anti-CD4) (Ab182802) is more than 95% verified by HPLC.

Objetivos asociados (humanos)

CD4 Tclin T-cell surface glycoprotein CD4 (0 Activities)

Discover Target: CD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de acción

Preguntas frecuentes

What does Animal Free mean?

Animal Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

What does Carrier Free mean?

Carrier Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

How should this product be stored?

Store at ?80 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2409099-32-5.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Which species reactivity has this antibody been validated against?

Validated reactivity is listed on the PDP and on each lot's datasheet. We validate against the most commonly tested species for the target (Semzuvolimab (anti-CD4)); cross-reactivity in untested species may exist but is not guaranteed. Contact technical support for specific species inquiries.