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Anticorps
Anticorps primaires
ECT2 Mouse mAb - Anticorps primaire, specific to ECT2, Mouse IgG1

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ECT2 Mouse mAb - Anticorps primaire, specific to ECT2, Mouse IgG1

Name: ECT2 Mouse mAb - Anticorps primaire, specific to ECT2, Mouse IgG1
SKU: Ab100925
Availability: InStock

En stock

SKU

Ab100925

Articles du produit groupé
Nom du produit	Qté
[Ab100925-10μl] ECT2 Mouse mAb (10μl) 86,69 €
[Ab100925-50μl] ECT2 Mouse mAb (50μl) 225,53 €
[Ab100925-100μl] ECT2 Mouse mAb (100μl) 364,36 €
[Ab100925-1ml] ECT2 Mouse mAb (1ml) 2 950,23 €

mAb (1691CT516.3.3); Mouse anti Human ECT2 Antibody; WB; Unconjugated

Mouse anti Human ECT2 Antibody, Monoclonal (1691CT516.3.3), could be used for WB and so on.

Application

WB: 1/1000

Protein Function

Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

Plus d’information

Plus d’information
Cible	ECT2
Clone	1691CT516.3.3
Gene Id	1894
Accession #	Q9H8V3
Symbole génétique	ECT2
Synonymes	ARHGEF31 \| ECT 2 antibody \| ECT2 antibody \| ECT2 protein antibody \| ECT2_HUMAN antibody \| Epithelial cell transforming sequence 2 antibody \| Epithelial cell transforming sequence 2 oncogene antibody \| Epithelial cell transforming sequence 2 oncogene prote
Spécifications et pureté	ExactAb™, Validated, Carrier Free, 0.5 mg/mL
Spécificité	ECT2
Immunogène	Recombinant ECT2 expressed in E.coli (AA 200-460)
Contrôle positif	WB: HT-29, A549 and SK-OV-3 cell lysates.
Isotype	Mouse IgG1
Type de chaîne lumineuse	kappa
SDS-PAGE	150 kDa
Méthode de purification	Protein G purified
Concentration	0.5 mg/mL
Product Description	Mouse anti Human ECT2 Antibody, Monoclonal (1691CT516.3.3), could be used for WB and so on. Application WB: 1/1000 Protein Function Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Forme	Liquid
Conditions de stockage de stockage	Store at -20°C,Avoid repeated freezing and thawing
Expédié en	Ice chest + Ice pads
Stabilité et stockage	Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.