EI1 - Moligand™, ≥96% , Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit, CAS No.1418308-27-6, Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit

CAS: 1418308-27-6 Cat. No.: E125706 Formule: C₂₃H₂₆N₄O₂ Poids moléculaire: 390.48

QUALITÉ & PURETÉ Moligand™, ≥96%

Synonyms

6-cyano-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-1-(pentan-3-yl)-1H-indole-4-carboxamide|EI1; Ezh2 inhibitor|6-Cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide|Ezh2 inhibitor;EI-1;EI 1|6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide|6-cyano-n-((1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl)-1-(1-ethylpropyl)-1h-indole-4-carboxamide|6-cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-pentan-3-ylindole-4-carboxamide|EI1

Storage

A l'abri de la lumière,A conserver à -20°C

Shipped In

Glacière + blocs de glace

Vue d’ensemble

EI1 est un inhibiteur puissant et sélectif d'EZH2 avec des IC50 de 15 nM et 13 nM pour EZH2 (WT) et EZH2 (Y641F), respectivement.

Spécifications

Synonymes

6-cyano-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-1-(pentan-3-yl)-1H-indole-4-carboxamide | EI1; Ezh2 inhibitor | 6-Cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide | Ezh2 inhibitor;EI-1;EI 1 | 6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)- Afficher plus

Spécifications et pureté

Moligand™, ≥96%

Mécanismes biochimiques et physiologiques

EI1 a démontré une inhibition puissante et dépendante de la concentration de l'activité enzymatique contre les enzymes de type sauvage Ezh2 et les enzymes mutantes Y641F avec des IC50 de 15 ± 2 nM et 13 ± 3 nM, respectivement. Bien que la SAM soit le cofa

Conditions de stockage de stockage

A l'abri de la lumière,A conserver à -20°C

Expédié en

Glacière + blocs de glace

Grade

Moligand™

Type d'action

INHIBITOR

Mécanisme d'action

Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit

Note

Toxique, se référer à la FDS pour plus d'informations. Besoin de plus de conseils sur la solubilité, l'utilisation et la manipulation ? Veuillez consulter notre page de questions fréquemment posées (FAQ) pour plus de détails.

Pureté

≥96%

Noms et identifiants

Pubchem Sid

504772251

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504772251

Sourires canoniques

CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C

IUPAC Name

6-cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-pentan-3-ylindole-4-carboxamide

InChIKey

PFHDWRIVDDIFRP-UHFFFAOYSA-N

INCHI

1S/C23H26N4O2/c1-5-17(6-2)27-8-7-18-19(10-16(12-24)11-21(18)27)22(28)25-13-20-14(3)9-15(4)26-23(20)29/h7-11,17H,5-6,13H2,1-4H3,(H,25,28)(H,26,29)

Isomères SMILES

CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C

Poids moléculaire

390.48

Reaxy-Rn

29233172

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29233172&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Indoles and derivatives
      • Subclass Indolecarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Indoles and derivatives
• Subclass: Indolecarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Indolecarboxamides and derivatives
• Alternative Parents: N-alkylindoles Indoles Pyridinones Methylpyridines Dihydropyridines Substituted pyrroles Benzenoids Heteroaromatic compounds Secondary carboxylic acid amides Lactams Nitriles Azacyclic compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indolecarboxamide derivative - N-alkylindole - Indole - Dihydropyridine - Pyridinone - Methylpyridine - Benzenoid - Substituted pyrrole - Pyridine - Hydropyridine - Heteroaromatic compound - Pyrrole - Secondary carboxylic acid amide - Carboxamide group - Lactam - Carboxylic acid derivative - Azacycle - Nitrile - Carbonitrile - Organic oxide - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Hydrocarbon derivative - Cyanide - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as indolecarboxamides and derivatives. These are compounds containing a carboxamide group attached to an indole.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

EZH2 Tclin Histone-lysine N-methyltransferase EZH2 (8 Activities)

Discover Target: EZH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriétés chimiques et physiques

• Solubilité: insoluble in H2O; insoluble in EtOH; ≥19.5 mg/mL in DMSO
• Sensibilité: light sensitive
• Poids moléculaire: 390.500 g/mol
• XLogP3: 3.400
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 390.206 Da
• Monoisotopic Mass: 390.206 Da
• Topological Polar Surface Area: 86.900 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 771.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1