4-Methylmorpholin-3-one: Properties, Uses & FAQs

4-Methylmorpholin-3-one is a cyclic amide (lactam) bearing a methyl substituent on the morpholine nitrogen, widely employed as a versatile building block and solvent in organic synthesis research.

Chemical Name

4-Methylmorpholin-3-one

SKU / Product Code

M725384

Molecular Formula

C5H9NO2

Molecular Weight

115.13 g/mol

Compound Class

Cyclic amide (morpholinone / lactam)

Supplier

Aladdin Scientific

What Is 4-Methylmorpholin-3-one?

4-Methylmorpholin-3-one (CAS number to be confirmed; SKU M725384) is a six-membered heterocyclic compound containing both an oxygen atom and a nitrogen atom in the ring, with a carbonyl group adjacent to nitrogen, classifying it as a cyclic amide or lactam. The methyl group is attached directly to the ring nitrogen (position 4), distinguishing it from the parent morpholin-3-one scaffold.

Its relatively low molecular weight (approximately 115.13 g/mol) and the presence of hydrogen-bond-accepting groups make it of interest as a polar aprotic-like building block in medicinal chemistry and as an intermediate in the preparation of more complex heterocyclic architectures.

Common Laboratory Applications

4-Methylmorpholin-3-one is primarily used as a synthetic building block in organic and medicinal chemistry. Its morpholinone core is a privileged scaffold found in biologically active compounds, making it valuable for structure–activity relationship (SAR) studies.

Typical applications include:

• Heterocyclic synthesis: Used as a starting material or intermediate in the construction of fused or substituted ring systems.
• Medicinal chemistry: The morpholinone motif is explored in drug discovery programmes targeting various biological pathways.
• Reagent for amide-bond-forming reactions: The lactam ring can be ring-opened or functionalised under appropriate conditions to introduce amide or amino-alcohol fragments.

Researchers should consult primary literature for specific reaction protocols and confirm suitability for their particular application.

Handling, Storage, and Safety

As with all laboratory reagents, 4-Methylmorpholin-3-one should be handled using standard laboratory precautions:

• Personal protective equipment: Wear appropriate gloves, safety glasses, and a lab coat when handling this compound.
• Storage: Store in a cool, dry, well-ventilated area, tightly sealed, away from incompatible materials such as strong oxidising agents. Specific storage temperature should be confirmed from the product's Safety Data Sheet (SDS).
• Disposal: Dispose of in accordance with local regulations for chemical waste.

Note: Always refer to the current Safety Data Sheet (SDS) provided by Aladdin Scientific for authoritative hazard and handling information specific to SKU M725384.

Ordering and Quality Information

4-Methylmorpholin-3-one is available from Aladdin Scientific under SKU M725384. When placing an order, researchers and procurement staff should note the following:

• Purity and grade: Confirm the purity specification on the current product page or certificate of analysis (CoA) before ordering. Aladdin Scientific provides CoAs upon request.
• Pack sizes: Available pack sizes can be found on the Aladdin Scientific website; contact customer service for bulk or custom quantities.
• Lead time and shipping: Standard shipping conditions apply; consult the shipping and delivery policy for details regarding temperature-controlled transport if required.
• Returns and refunds: Refer to Aladdin Scientific's returns and refund policy for eligibility criteria.

Frequently asked questions

What is the molecular formula and molecular weight of 4-Methylmorpholin-3-one?

4-Methylmorpholin-3-one has the molecular formula C5H9NO2 and a molecular weight of approximately 115.13 g/mol. It is a six-membered cyclic amide containing one nitrogen and one oxygen in the ring.

What are the typical applications of 4-Methylmorpholin-3-one in research?

This compound is primarily used as a synthetic building block in organic and medicinal chemistry, particularly for constructing heterocyclic frameworks and exploring morpholinone-containing scaffolds in drug discovery. It may also serve as an intermediate in amide-bond-forming or ring-opening reactions.

How should 4-Methylmorpholin-3-one be stored?

It should be stored in a cool, dry, well-ventilated location in a tightly sealed container, away from strong oxidising agents and incompatible materials. Always consult the Safety Data Sheet (SDS) for SKU M725384 from Aladdin Scientific for specific storage temperature and conditions.

Where can I find the Certificate of Analysis (CoA) for SKU M725384?

The Certificate of Analysis for 4-Methylmorpholin-3-one (M725384) can be obtained from Aladdin Scientific's product page or by contacting customer service directly. The CoA details purity, lot-specific analytical data, and testing methods.

Is 4-Methylmorpholin-3-one available for bulk purchase?

Yes, Aladdin Scientific can accommodate bulk or custom quantity requests for M725384. Contact Aladdin Scientific's customer service team for pricing, lead times, and availability for larger quantities.

References

1. Aladdin Scientific product page: 4-Methylmorpholin-3-one, SKU M725384.
2. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley, 4th ed. (General reference for lactam and heterocycle chemistry.)
3. Safety Data Sheet (SDS) for 4-Methylmorpholin-3-one, M725384, Aladdin Scientific. (Specific hazard and storage data to be confirmed from official SDS.)

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.