Epigenetic Regulation

Acetyl-group metabolism lies at the intersection of central carbon metabolism, lipid synthesis, post-translational protein modification, and epigenetic regulation. Interconversion among acetyl-CoA, acetate, citrate, and multiple acyl intermediates not only determines the direction of carbon-flux ...

S-Adenosylmethionine is one of the most important activated methyl donors in cells and is widely involved in methyl-transfer reactions affecting DNA, RNA, proteins, lipids, and multiple classes of small molecules. Current understanding of methylation regulation has expanded from the level of ...

One-carbon metabolism is not merely a matter of folate nutrition, but rather a metabolism-signaling integrated system jointly constituted by the folate cycle, the methionine cycle, and the transsulfuration pathway. On the one hand, this system sustains nucleic acid synthesis and methylation ...