Granisetron - Moligand™, ≥98% , Antagonist of 5-HT 3A, CAS No.109889-09-0, Antagonist of 5-HT 3A

CAS: 109889-09-0 Cat. No.: G127257 Formule: C₁₈H₂₄N₄O Poids moléculaire: 312.41 Numéro CE: 686-533-5

GRADE & PURITY Moligand™, ≥98%

Synonyms

Sustol | UNII-WZG3J2MCOL | CHEBI:5537 | Z1501485362 | 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide | Granisetron (AB-1001) | GRANISETRON [MI] | LY-278584 | Q-101870 | DTXSID0023111 | NCGC00388522-02 | Sancuso | BRL-4369

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

Specifications

Synonymes

Sustol | UNII-WZG3J2MCOL | CHEBI:5537 | Z1501485362 | 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide | Granisetron (AB-1001) | GRANISETRON [MI] | LY-278584 | Q-101870 | DTXSID0023111 | NCGC00388522-02 | Sancuso | BRL-4369

Spécifications et pureté

Moligand™, ≥98%

Mécanismes biochimiques et physiologiques

Description:
IC50 Value: 17uM (GR reduced 5-HT-evoked contractions) [1]
Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
in vitro: In rat forest

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

ANTAGONIST

Mécanisme d'action

Antagonist of 5-HT 3A

Pureté

≥98%

Noms et identifiants

Pubchem Sid

504763499

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504763499

Sourires canoniques

CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C

IUPAC Name

1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide

InChIKey

MFWNKCLOYSRHCJ-AGUYFDCRSA-N

INCHI

1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12?,13-,14+

Isomères SMILES

CN1[C@@H]2CCC[C@H]1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C

Poids moléculaire

312.41

Reaxy-Rn

6660726

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6660726&ln=

Cibles associées (humaines)

HTR3B Tchem 5-hydroxytryptamine receptor 3B (0 Activities)

Discover Target: HTR3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR3A Tclin 5-hydroxytryptamine receptor 3A (0 Activities)

Discover Target: HTR3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (0 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriétés chimiques et physiques

• Solubilité: DMSO:11 mg/mL
• Poids moléculaire: 312.400 g/mol
• XLogP3: 2.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 312.195 Da
• Monoisotopic Mass: 312.195 Da
• Topological Polar Surface Area: 50.200 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 442.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 109889-09-0, the molecular formula is C18H24N4O, and the molecular weight is 312.41 g/mol. InChIKey MFWNKCLOYSRHCJ-AGUYFDCRSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.