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· · COA & SDS disponible pour chaque produit · Expédition le jour même sur les articles en stock MK-5108 (VX-689) - Moligand™, ≥98% , Serine/threonine-protein kinase Aurora-A inhibitor, CAS No.1010085-13-8, Serine/threonine-protein kinase Aurora-A inhibitor
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% Synonyms
HMS3656D06 | NCGC00024591-03 | BRD-K53665955-001-01-4 | GTPL8061 | MK 5108 | NSC800796 | NSC-800796 | MFCD22124479 | trans-4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid | SW220174-1 | trans-4-(
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonymes
HMS3656D06 | NCGC00024591-03 | BRD-K53665955-001-01-4 | GTPL8061 | MK 5108 | NSC800796 | NSC-800796 | MFCD22124479 | trans-4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid | SW220174-1 | trans-4-(
Spécifications et pureté
Moligand™, ≥98%
Mécanismes biochimiques et physiologiques
MK-5108 (VX-689) is a highly selective Aurora-A kinase inhibitor with an IC50 of 0.064 nM. MK-5108 is a novel small molecule with potent inhibitory activity against Aurora-A kinase. Although most of the Aurora-kinase inhibitors target bot
Conditions de stockage de stockage
Store at -20°C
Expédié en
Ice chest + Ice pads
Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.
Mécanisme d'action
Serine/threonine-protein kinase Aurora-A inhibitor
Propriétés du produit Noms et identifiants Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/488200675
Sourires canoniques
C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O
IUPAC Name
4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid
InChIKey
LCVIRAZGMYMNNT-UHFFFAOYSA-N
INCHI
1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)
Isomères SMILES
C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24898269&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Benzenoids Classe Phenol ethers Subclass Not available Intermediate Tree Nodes Not available Direct Parent Phenol ethers Alternative Parents Phenoxy compounds Alkyl aryl ethers Aminopyridines and derivatives Chlorobenzenes Fluorobenzenes 2-amino-1,3-thiazoles Aryl chlorides Aryl fluorides Imidolactams Heteroaromatic compounds Amino acids Carboxylic acids Azacyclic compounds Secondary amines Monocarboxylic acids and derivatives Organochlorides Organofluorides Carbonyl compounds Hydrocarbon derivatives Organopnictogen compounds Organic oxides Molecular Framework Aromatic heteromonocyclic compounds Substituents Phenoxy compound - Phenol ether - Alkyl aryl ether - Halobenzene - Aminopyridine - Fluorobenzene - Chlorobenzene - Aryl chloride - Aryl fluoride - Pyridine - Monocyclic benzene moiety - Imidolactam - Aryl halide - 1,3-thiazol-2-amine - Azole - Thiazole - Heteroaromatic compound - Amino acid - Amino acid or derivatives - Azacycle - Organoheterocyclic compound - Secondary amine - Carboxylic acid derivative - Carboxylic acid - Ether - Monocarboxylic acid or derivatives - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Amine - Organic nitrogen compound - Organooxygen compound - Organic oxide - Organonitrogen compound - Organofluoride - Hydrocarbon derivative - Organohalogen compound - Organochloride - Aromatic heteromonocyclic compound Description This compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Structure 3D Cibles associées (humaines) Certificats (CoA, COO, BSE/TSE et tableau d'analyse) Propriétés chimiques et physiques Solubilité DMSO 92 mg/mL Water <1 mg/mL Ethanol <1 mg/mL Poids moléculaire 461.900 g/mol XLogP3 5.400 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 8 Rotatable Bond Count 7 Exact Mass 461.098 Da Monoisotopic Mass 461.098 Da Topological Polar Surface Area 113.000 Ų Heavy Atom Count 31 Formal Charge 0 Complexity 611.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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