S 3304 - 10mM in DMSO , CAS No.203640-27-1

CAS: 203640-27-1 Cat. No.: S656084 Formule: C₂₄H₂₀N₂O₄S₂ Poids moléculaire: 464.6 PubChem CID: 10718956

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

S 3304 is a novel matrix metalloproteinases ( MMP ) inhibitor specific for MMP-2 and MMP-9 .

In Vitro

S 3304 is a novel D-tryptophan derivative and a potent, orally active, noncytotoxic Matrix metalloproteinases inhibitor (MMPI). Biochemical studies show that S 3304 most potently inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In vivo pharmacologic studies have shown that the oral administration of S 3304, at a dose range of 20 to 200 mg/kg, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 result in potent inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:MMP-9

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

S 3304 is a novel matrix metalloproteinases ( MMP ) inhibitor specific for MMP-2 and MMP-9 .

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

• Isomères SMILES: CC1=CC=C(C=C1)C#CC2=CC=C(S2)S(=O)(=O)N[C@H](CC3=CNC4=CC=CC=C43)C(=O)O
• CAS alternatif: 203640-27-1
• PubChem CID: 10718956
• Termes d'entrée MeSH: S 3304;S-3304;S3304 cpd
• Poids moléculaire: 464.6

Cibles associées (humaines)

MMP9 Tchem Matrix metalloproteinase-9 (2 Activities)

Discover Target: MMP9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP2 Tchem 72 kDa type IV collagenase (2 Activities)

Discover Target: MMP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 203640-27-1, the molecular formula is C24H20N2O4S2, and the molecular weight is 464.6 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.