Simvastatin - Moligand™, ≥97%(HPLC) , HMG-CoA reductase inhibitor, CAS No.79902-63-9, HMG-CoA reductase inhibitor

CAS: 79902-63-9 Cat. No.: S129538 Molecular Weight: 418.57 EC Number: 691-267-8 PubChem CID: 54454
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%(HPLC)
Synonyms
BRN 4768037 | Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester | MK 0733 | SIMVASTATIN [MART.] | Sinvascor | L 644128-000U | Zocord | Sim
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
250mg
S129538-250mg
3
$9.90
1g
S129538-1g
3
$9.90
5g
S129538-5g
2
$13.90
10g
S129538-10g
1
$29.90
25g
S129538-25g
3
$39.90
100g
S129538-100g
1
$99.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

Moligand™, ≥97%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 36 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Product Description

Simvastatin is a prodrug. Simvastatin is a semisynthetic derivative/analog of lovastatin. Simvastatin is insoluble in water but is soluble in polar organic solvents.

Product Application

Simvastatin has been used:
• as an inhibitor of HMG CoA reductase (HMGCR)
• to study its effects on epithelial to mesenchymal transition (EMT) and the prognosis of patients with lung adenocarcinoma
• in in vivo studies to test its effect on brain tumor−initiating cells (BTIC) viability and cell proliferation
• to study the role of adenosine triphosphate (ATP)-binding cassette transporter A7 in phagocytosis of Jurkat cells
• to study the effect on endothelial dysfunction and inflammation in mice

Specifications

Synonyms
BRN 4768037 | Butanoic acid, 2, 2-dimethyl-, (1S, 3R, 7S, 8S, 8aR)-1, 2, 3, 7, 8, 8a-hexahydro-3, 7-dimethyl-8-[2-[(2R, 4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester | MK 0733 | SIMVASTATIN [MART.] | Sinvascor | L 644128-000U | Zocord | Sim
Specifications & Purity
Moligand™, ≥97%(HPLC)
Biochemical and Physiological Mechanisms
Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylgluta
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
HMG-CoA reductase inhibitor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥97%(HPLC)
Product Properties
ALogP4.7
Names and Identifiers
Canonical SmilesCCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
IUPAC Name[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
InChIKeyRYMZZMVNJRMUDD-HGQWONQESA-N
INCHI1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
Isomeric SMILES CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
WGK Germany 2
RTECS EK7798000
PubChem CID 54454
Molecular Weight 418.57
Reaxy-Rn 4768037

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassLactones
SubclassDelta valerolactones
Intermediate Tree Nodes Not available
Direct ParentDelta valerolactones
Alternative Parents Fatty acid esters  Oxanes  Dicarboxylic acids and derivatives  Secondary alcohols  Carboxylic acid esters  Oxacyclic compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic heteropolycyclic compounds
Substituents Delta_valerolactone - Fatty acid ester - Delta valerolactone - Fatty acyl - Oxane - Dicarboxylic acid or derivatives - Secondary alcohol - Carboxylic acid ester - Oxacycle - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as delta valerolactones. These are cyclic organic compounds containing an oxan-2- one moiety.
External Descriptors statin (semi-synthetic) - fatty acid ester - delta-lactone - carbobicyclic compound
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase (15 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
INSR Tclin Insulin receptor (5558 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RARA Tclin Retinoic acid receptor alpha (1324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Htr7 Serotonin 7 (5-HT7) receptor (19 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fdft1 Squalene synthetase (34 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ntsr1 Neurotensin receptor 1 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bdkrb1 Bradykinin B1 receptor (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Icmt Isoprenylcysteine carboxyl methyltransferase (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium berghei (192651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cricetinae gen. sp. (3197 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEF (1005 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L6 (7924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Alpha trans-inducing protein (VP16) (945 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
dengue virus type 2 (2400 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase (17 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slco1a1 Solute carrier organic anion transporter family member 1A1 (265 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slco1a4 Solute carrier organic anion transporter family member 1A4 (114 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Glra2 Glycine receptor (1745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

29 results found

Lot NumberCertificate TypeDateItem
D2624367Certificate of AnalysisApr 11, 2026 S129538
D2624368Certificate of AnalysisApr 11, 2026 S129538
D2624369Certificate of AnalysisApr 11, 2026 S129538
D2624370Certificate of AnalysisApr 11, 2026 S129538
A2404354Certificate of AnalysisOct 13, 2025 S129538
L2301383Certificate of AnalysisSep 09, 2025 S129538
L2301382Certificate of AnalysisSep 09, 2025 S129538
L2301267Certificate of AnalysisSep 09, 2025 S129538
L2301266Certificate of AnalysisSep 09, 2025 S129538
K2302026Certificate of AnalysisAug 11, 2025 S129538
J2408660Certificate of AnalysisSep 12, 2024 S129538
L2511062Certificate of AnalysisSep 12, 2024 S129538
J2408670Certificate of AnalysisSep 12, 2024 S129538
J2408664Certificate of AnalysisSep 12, 2024 S129538
J2408662Certificate of AnalysisSep 12, 2024 S129538
J2408659Certificate of AnalysisSep 12, 2024 S129538
J2408658Certificate of AnalysisSep 12, 2024 S129538
I2516039Certificate of AnalysisSep 12, 2024 S129538
I2504097Certificate of AnalysisSep 12, 2024 S129538
H2520024Certificate of AnalysisSep 12, 2024 S129538
I2414041Certificate of AnalysisNov 17, 2023 S129538
L2301381Certificate of AnalysisNov 17, 2023 S129538
L2103127Certificate of AnalysisSep 19, 2023 S129538
L2103128Certificate of AnalysisSep 19, 2023 S129538
L2103129Certificate of AnalysisSep 19, 2023 S129538
K2017174Certificate of AnalysisSep 20, 2022 S129538
G2315047Certificate of AnalysisAug 25, 2021 S129538
E2305057Certificate of AnalysisAug 25, 2021 S129538
D2328032Certificate of AnalysisAug 25, 2021 S129538

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Chemical and Physical Properties
SolubilitySoluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), water (0.03 mg/l), and methanol.
SensitivityMoisture & Air sensitive
Specific Rotation[α]293° (C=1,CH3CN)
Melt Point(°C)134°C
Molecular Weight418.600 g/mol
XLogP34.700
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass418.272 Da
Monoisotopic Mass418.272 Da
Topological Polar Surface Area72.800 Ų
Heavy Atom Count30
Formal Charge0
Complexity706.000
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Yulin Mo, Yanjun Yang, Jingqi Zeng, Weikun Ma, Yuxin Guan, Jingxi Guo, Xiaochun Wu, Dingkun Liu, Liang Feng, Xiaobin Jia, Bing Yang.  (2023)  Enhancing the Biopharmacological Characteristics of Asperosaponin VI: Unveiling Dynamic Self-Assembly Phase Transitions in the Gastrointestinal Environment.  International Journal of Nanomedicine,      [PMID:38084126] [10.2147/IJN.S436372]
2. Xiaojie Xu, Jiahui Zuo, Huajing Zeng, Yuan Zhao, Zengjie Fan.  (2023)  Improving Osseointegration Potential of 3D Printed PEEK Implants with Biomimetic Periodontal Ligament Fiber Hydrogel Surface Modifications.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202308811]
3. Xuejing Yang, Wenyu Cao, Xun Gu, Lijie Zheng, Qiuyue Wang, Yingying Li, Fang Wei, Tao Ma, Lu Zhang, Qingqing Wang.  (2023)  Simvastatin nanocrystals-based dissolving microneedles for wound healing.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:37879572] [10.1016/j.ijpharm.2023.123543]
4. Wei Peng, Yufeng Qian, Xuchen Qi.  (2023)  Efficacy of a novel glioma therapy based on ferroptosis induced by layered double hydroxide loaded with simvastatin.  ENVIRONMENTAL RESEARCH,      [PMID:37717807] [10.1016/j.envres.2023.117112]
5. Qingxin Shi, Yuqi Lin, Lu Huang, Shuna Jin, Rongzeng Huang, Lijun Zhang, Chengwu Song, Lei Xu, Shiying Zhang.  (2023)  Elucidating the mechanisms underlying the anti-hyperlipidemic effects of Laportea bulbifera using integrated serum metabolomics and network pharmacology.  BIOMEDICAL CHROMATOGRAPHY,  37  (10): (e5707).  [PMID:37496197] [10.1002/bmc.5707]
6. Yanbin Zhao, Peng He, Junyan Yao, Mei Li, Bin Wang, Linyuan Han, Zhihai Huang, Chao Guo, Jing Bai, Feng Xue, Yu Cong, Weihua Cai, Paul K. Chu, Chenglin Chu.  (2023)  pH/NIR-responsive and self-healing coatings with bacteria killing, osteogenesis, and angiogenesis performances on magnesium alloy.  BIOMATERIALS,      [PMID:37467596] [10.1016/j.biomaterials.2023.122237]
7. Qiao Bian, Chao Guo, Shuquan Cui, Jia Liu, Guohua Xu, Wei Feng.  (2023)  Accelerating bone regeneration in cranial defects using an injectable organic–inorganic composite hydrogel.  Journal of Materials Chemistry B,  11  (16): (3713-3726).  [PMID:37066627] [10.1039/D3TB00332A]
8. Shuwen Xu, Zhiyong Wu, Gaofeng Cai, Yue Zhang, Song Peng, Lina Jiao, Zhenguang Liu, Yang Yang, Deyun Wang.  (2023)  Astragalus polysaccharides combined with simvastatin as an immunostimulant enhances the immune adjuvanticity of oil-in-water emulsion and immune responses in mice.  VACCINE,      [PMID:36754767] [10.1016/j.vaccine.2023.01.069]
9. Ling-Feng Zhang, Xing-Huan Wang, Cheng-Lu Zhang, Jaiwoo Lee, Bo-Wen Duan, Lei Xing, Ling Li, Yu-Kyoung Oh, Hu-Lin Jiang.  (2022)  Sequential Nano-Penetrators of Capillarized Liver Sinusoids and Extracellular Matrix Barriers for Liver Fibrosis Therapy.  ACS Nano,      [PMID:36036898] [10.1021/acsnano.2c03858]
10. Mohammed A. Al-Baadani, Kendrick Hii Ru Yie, Abdullrahman M. Al-Bishari, Bilal A. Alshobi, Zixin Zhou, Kai Fang, Binwei Dai, Yiding Shen, Jianfeng Ma, Jinsong Liu, Xinkun Shen.  (2021)  Co-electrospinning polycaprolactone/gelatin membrane as a tunable drug delivery system for bone tissue regeneration.  MATERIALS & DESIGN,      [PMID:] [10.1016/j.matdes.2021.109962]
11. Li-Jun Deng, Yan-Lin Wu, Xian-Hua He, Ke-Nan Xie, Lu Xie, Yi Deng.  (2018)  Simvastatin delivery on PEEK for bioactivity and osteogenesis enhancements.  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,      [PMID:30307376] [10.1080/09205063.2018.1534668]
12. Jixiang Song, Pengfei Chen, Longsheng Zhang, Junbo Hu, Ruining Yang, Pengfei Sun, Yanqin Huang, Xingfen Liu, Xiaomei Lu, Quli Fan.  (2024)  A novel near-infrared-II fluorescence probe for serum albumin biosensing and site-binding mechanism study.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2024.136355]
13. Zishuo Zhou, Yaxue Liu, Pei Xie, Zongning Yin.  (2024)  A ROS-responsive multifunctional targeted prodrug micelle for atherosclerosis treatment.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:38901540] [10.1016/j.ijpharm.2024.124352]
14. Yunhui Liao, Feng Chen, Haishan Tang, Wubliker Dessie, Zuodong Qin.  (2024)  Combination of a Deep Eutectic Solvent and Macroporous Resin for Green Recovery of Iridoids, Chlorogenic Acid, and Flavonoids from Eucommia ulmoides Leaves.  MOLECULES,  29  (3): (737).  [PMID:38338480] [10.3390/molecules29030737]
15. Lin Fu, Hengxin Ren, Chaoxing Wang, Yaxin Zhao, Bohang Zou, Xiangyu Zhang.  (2025)  Formation of PEG-PLGA Microspheres for Controlled Release of Simvastatin and Carvacrol: Enhanced Lipid-Lowering Efficacy and Improved Patient Compliance in Hyperlipidemia Therapy.  Polymers,  17  (5): (574).  [PMID:40076067] [10.3390/polym17050574]
16. Wenqin Yang, Yulong Shi, Yiwei Zhang, Yating Yang, Yufan Du, Zixiao Yang, Xiaorong Wang, Ting Lei, Yanyan Xu, Yongke Chen, Fan Tong, Yazhen Wang, Qianqian Huang, Chuan Hu, Huile Gao.  (2024)  Intranasal Carrier-Free Nanomodulator Addresses Both Symptomatology and Etiology of Alzheimer’s Disease by Restoring Neuron Plasticity and Reprogramming Lesion Microenvironment.  ACS Nano,      [PMID:39415568] [10.1021/acsnano.4c09449]
17. Shuang Wang, Chunyue Zhao, Xueran Huang, Yongfen Gao, Yang Qiu, Rui Jiao, Hanyue Zhu, Huafang Ding, Rui Lin, Zouyan He.  (2024)  Lonicerin attenuates high-fat diet-induced hepatic steatosis through modulation of the gut microbiota-bile acid-FXR axis in mice.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2024.106466]
18. Juan Zhou, Yanling Zhao, Yan Ling, Peng Zhao, Hui Gao, Yang Yang, Jinghua Chen.  (2024)  Microsphere-Composite Hydrogel for Recruiting Stem Cells and Promoting Osteogenic Differentiation.  ACS Applied Bio Materials,      [PMID:39263987] [10.1021/acsabm.4c00679]
19. Yingnan Liu, Guofang Zhang, Qi Li, Jiaxin Chen, Wenhe Luo, Xuejin Li, Xiaoman Suo, Su Li, Yaqing Xu, Tinghao Liu, Feng Yuan, Fangfang Liu, Yanqiao Zeng, Yingze Wang, Yang Li.  (2024)  Nano-assemblies overcome cancer multidrug resistance for effectively synergistic chemo-immuno-oncotherapy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.151437]
20. Bin Wang, Yanbin Zhao, Yangyang Li, Junyan Yao, Shunjie Wu, Guoping Miu, Chenglin Chu.  (2024)  NIR-responsive magnesium phosphate cement loaded with simvastatin-nanoparticles with biocompatibility and osteogenesis ability.  RSC Advances,  14  (20): (13958-13971).  [PMID:38686291] [10.1039/D4RA01079E]
21. Yang Chen, Wenzhe Xu, Hao Jin, Mengsi Zhang, Shuwei Liu, Yi Liu, Hao Zhang.  (2024)  Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors.  ACS Nano,      [PMID:39512234] [10.1021/acsnano.4c08083]
22. Xiaolin Ma, Xuan Zhao, Yulong Yang, Jinjin Yan, Xiaoyan Shi, Hongfei Wu, Yarong Liu, Min Dai.  (2025)  Paeonol inhibits NETs-mediated foam cell inflammation through the CitH3/NLRP3/caspase-1 signaling pathway in atherosclerosis.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:40020464] [10.1016/j.intimp.2025.114340]
23. Liping Liu, Tao Yang, Shaoru Wang, Wenyuan Jia, Yun Liu, Kun Jiao, Yongzheng Yan, Yuheng Yang, Xuanzuo Jiang, Chiyu Li, Zhiqiang Cheng, Guomin Liu, Yungang Luo.  (2024)  Preparation and design of intelligent multi-response PTMC/PVP composite nanofibrous dressing to promote wound closure and its applications in diabetic wounds.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.153872]
24. Ning Gao, Yuanzhen Liu, Guangjie Liu, Bo Liu, Yupeng Cheng.  (2024)  Sanghuangporus vaninii extract ameliorates hyperlipidemia in rats by mechanisms identified with transcriptome analysis.  Food Science & Nutrition,      [PMID:38726415] [10.1002/fsn3.4002]
25. Xiqian Tan, Anqi Sun, Shuaibo Gao, Fangchao Cui, Dangfeng Wang, Xuepeng Li, Jianrong Li.  (2024)  Screen and characteristics of lactic acid bacteria with the ability to modulate energy metabolism and degrade uric acid.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.105723]
26. Lulu Zhao, Yongbo Peng, Jing Huang, Nishang Liu, Xinrong Zou, Junnan Li, Yunpeng Fan, Ping Li, Liling Tang, Jisheng Wang, Yajun Zeng, Yi Wu, Gaohui Zhu.  (2025)  Structural characterization of polysaccharides from Polygonatum Sibiricum and effect on alleviating hyperlipidemia in egg yolk emulsion-induced mice.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39805457] [10.1016/j.ijbiomac.2025.139808]
27. Menglong Gao, Lishun Dong, Yulong Yang, Jinjin Yan, Yuning Liang, Xiaolin Ma, Min Zhou, Hongfei Wu, Yarong Liu, Min Dai.  (2024)  The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:38518720] [10.1016/j.bbrc.2024.149788]
28. Yuan-yuan Zhai, Qiang Wang, Qi-yao Nong, Mei-yu Gao, Ying Zhang, Qin-wen Xiao, Yuan Tian, Zun-jian Zhang, Feng-guo Xu, Pei Zhang.  (2025)  Pitavastatin overcomes multi-drug resistance in CRC and NSCLC by targeting the NRP1-ZFX axis.  BIOCHEMICAL PHARMACOLOGY,      [PMID:40684995] [10.1016/j.bcp.2025.117183]
29. Fang-Ning Qiu, Qiao-Lei Wang, Ping Li, Qiu-Yi Pu, Hui-Jun Li.  (2025)  Revealing the chemical and pharmacological individualities of two pharmacopoeial Paris species for the purpose of precise medication.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:40796021] [10.1016/j.jep.2025.120402]
30. Lifeng Niu, Lina Ding, Chunyun Lu, Feifei Zuo, Ke Yao, Shaobo Xu, Wen Li, Donghua Yang, Xia Xu.  (2016)  Flavokawain A inhibits Cytochrome P450 in in vitro metabolic and inhibitory investigations.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:27318274] [10.1016/j.jep.2016.06.039]
31. Zhiwei Chen, Xinyu Di, Heyan Chen, Shengnan Song, Siyi Zhu, Leer Cai, Yuqi Han, Yongshuai Kang, Dingchao Shen, Huirong Huang, Aimin Cai, Hailun Zheng, Qing Yao, Maoping Chu, Ruijie Chen, Longfa Kou.  (2025)  Inflammation-targeted nanoparticles modulate macrophage polarization for coronary therapy in Kawasaki disease.  JOURNAL OF CONTROLLED RELEASE,      [PMID:41135700] [10.1016/j.jconrel.2025.114350]
32. Siyu Du, Yi Zheng, Yabing Chen, Yijing Guo, Xinyue Kang, Lei Wang.  (2025)  Fighting periodontitis with a pH-triggered nanocoating: A sustained-release strategy for simvastatin delivery.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:41418367] [10.1016/j.colsurfb.2025.115375]
33. Chengxi Wu, Yaoyao Li, Yuting Liu, Xueqin Wang, Ping Yuan, Maochang Xu, Yiping Deng, Zongquan Zhang, Chunhong Li, Xiangyu Zhou.  (2025)  Co-Targeting Biomimetic Nanoparticles Alleviate Atherosclerosis by Inhibiting the Vicious Circle Between Inflammation and Lipids.  International Journal of Nanomedicine,      [PMID:41477526] [10.2147/IJN.S558039]
34. Xiaorong Kou, Xue Wu, Tao He, Liping Bai, Xinchao Li, Rui Luo, Yangsong Xu, Yixi Wang, Meiling Shen, Changyang Gong, Qinjie Wu.  (2026)  Tumor-activated dual metabolic nanomodulator turns over tolerogenic tumor control and unleashes systemic immune responses.  JOURNAL OF NANOBIOTECHNOLOGY,      [PMID:41629977] [10.1186/s12951-026-04086-x]
35. Wanqing Zhan, Qiqi Wen, Haiyan Yao, Junchao Wei.  (2026)  PLLA/Simvastatin-Loaded Mesoporous Bioactive Glass Nanofibrous Scaffolds with Improved Osteogenic Activity and Mechanical Properties for Bone Tissue Engineering.  Polymers,  18  (3): (398).  [PMID:41682105] [10.3390/polym18030398]
36. Duo Sun, Shihui Yang, Shuwei Qiao, Zhuoran Wang, Xiao Han, Sihan Ma, Heyi Gong, Jinghui Zhao, Fei Yan.  (2026)  Bimetallic MOF-engineered 3D-printed PEEK implants orchestrate osteoregeneration via macrophage reprogramming.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2026.174630]
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