SRT1720 HCl - ≥98% , CAS No.1001645-58-4

CAS: 1001645-58-4 Cat. No.: S129890 Formule: C₂₅H₂₃N₇OS.HCl Poids moléculaire: 506.02 PubChem CID: 25232708

GRADE & PURITY ≥98%

Synonyms

SRT 1720 Hydrochloride | BCP01774 | SRT-1720, SRT1720 | FT-0761472 | SRT1720 xHydrochloride | SCHEMBL16372055 | J-523315 | SRT1720 | DTXSID80649411 | J-000057 | N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide hydr

Storage

Conserver à -20°C

Shipped In

Glacière + blocs de glace

Vue d’ensemble

SRT1720 est un activateur sélectif de SIRT1 avec une CE50 de 0,16 μM, mais il est >230 fois moins puissant pour SIRT2 et SIRT3.
Un activateur sélectif de la SIRT1

Specifications

Synonymes

SRT 1720 Hydrochloride | BCP01774 | SRT-1720, SRT1720 | FT-0761472 | SRT1720 xHydrochloride | SCHEMBL16372055 | J-523315 | SRT1720 | DTXSID80649411 | J-000057 | N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide hydr

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

SRT1720 est un activateur de la désacétylase NAD-dépendante sirtuine-1 (SIRT1) (EC50 = 0,16 μM), hautement sélectif pour SIRT1 par rapport à SIRT2 ou SIRT3. Des études menées chez la levure suggèrent que les sirtuines pourraient être impliquées dans le si

Conditions de stockage de stockage

Conserver à -20°C

Expédié en

Glacière + blocs de glace

Note

Se référer à la FDS pour plus d'informations Vous avez besoin de plus de conseils sur la solubilité, l'utilisation et la manipulation ? Veuillez consulter notre page de questions fréquemment posées (FAQ) pour plus de détails.

Pureté

≥98%

Noms et identifiants

Pubchem Sid

504770034

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504770034

Sourires canoniques

C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl

IUPAC Name

N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;hydrochloride

InChIKey

DTGRRMPPXCRRIM-UHFFFAOYSA-N

INCHI

1S/C25H23N7OS.ClH/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31;/h1-8,13,15-16,26H,9-12,14H2,(H,29,33);1H

Isomères SMILES

C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl

PubChem CID

25232708

Poids moléculaire

506.02

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Anilides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Anilides
• Intermediate Tree Nodes: Not available
• Direct Parent: Aromatic anilides
• Alternative Parents: Phenylimidazoles Quinoxalines Pyrazinecarboxamides 2-heteroaryl carboxamides Aralkylamines N-alkylpiperazines N-substituted imidazoles Heteroaromatic compounds Thiazoles Trialkylamines Secondary carboxylic acid amides Amino acids and derivatives Dialkylamines Azacyclic compounds Organic oxides Hydrochlorides Hydrocarbon derivatives Organooxygen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Aromatic anilide - 5-phenylimidazole - 4-phenylimidazole - Quinoxaline - Pyrazine carboxylic acid or derivatives - Pyrazinecarboxamide - 2-heteroaryl carboxamide - N-alkylpiperazine - Aralkylamine - 1,4-diazinane - N-substituted imidazole - Piperazine - Pyrazine - Thiazole - Heteroaromatic compound - Azole - Imidazole - Tertiary amine - Secondary carboxylic acid amide - Tertiary aliphatic amine - Carboxamide group - Amino acid or derivatives - Secondary amine - Organoheterocyclic compound - Azacycle - Carboxylic acid derivative - Secondary aliphatic amine - Hydrochloride - Organonitrogen compound - Amine - Organooxygen compound - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as aromatic anilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with an aromatic group. They have the general structure RNC(=O)R', where R= benzene, and R = aryl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

AOX1 Tchem Aldehyde oxidase (429 Activities)

Discover Target: AOX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: DMSO 38 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
• Poids moléculaire: 506.000 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 505.145 Da
• Monoisotopic Mass: 505.145 Da
• Topological Polar Surface Area: 116.000 Ų
• Heavy Atom Count: 35
• Formal Charge: 0
• Complexity: 707.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Foire aux questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1001645-58-4, the molecular formula is C25H23N7OS.HCl, and the molecular weight is 506.02 g/mol. InChIKey DTGRRMPPXCRRIM-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.