Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 6 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
U0126 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC 50 s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor .
| Isomeric SMILES | C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N |
|---|---|
| PubChem CID | 3006531 |
| Molecular Weight | 380.49 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| 1. Chen Xue, Zhou Xing-Yue, Lan Cai, Fu Hai-Jun, Li Zhi-Chao, Chen Meng-Yi, Wen Yong-Ping, Yu Lu, Qin Da-Lian, Wu An-Guo, Wu Jian-Ming, Zhou Xiao-Gang. (2025) Araloside A Induces Raf/MEK/ERK-Dependent Autophagy to Mitigate Alzheimer’s and Parkinson’s Pathology in Cellular and C. elegans Models. MOLECULAR NEUROBIOLOGY, [PMID:40742404] [10.1007/s12035-025-05242-4] |
| 2. Tianyi Yang, Yan Chen, Maolin Wang, Ren Ren, Fang Yan, Peng Xu, Bin Di. (2025) Multi-omics analysis reveals miR-7220-5p alleviates N2O addictive behaviors via NR2B/ERK/CREB signaling. JOURNAL OF NEUROSCIENCE, [PMID:40675813] [10.1523/JNEUROSCI.1410-24.2025] |
| 3. Zhou Jin, Ding Yuanyuan, Zhang Yongqiang, Zheng Dehui, Yan Lifeng, Guo Mengxiang, Mao Yani, Yang Lihong. (2022) Exosomes from bone marrow-derived mesenchymal stem cells facilitate corneal wound healing via regulating the p44/42 MAPK pathway. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 261 (3): (723-734). [PMID:36576571] [10.1007/s00417-022-05956-4] |
| 4. Shixuan Cui, Yang Yu, Tingjie Zhan, Yuchen Gao, Jiachen Zhang, Liang Zhang, Zhiwei Ge, Weiping Liu, Chunlong Zhang, Shulin Zhuang. (2021) Carcinogenic Risk of 2,6-Di-tert-Butylphenol and Its Quinone Metabolite 2,6-DTBQ Through Their Interruption of RARβ: In Vivo, In Vitro, and In Silico Investigations. ENVIRONMENTAL SCIENCE & TECHNOLOGY, [PMID:34927421] [10.1021/acs.est.1c06866] |
| 5. Aonan Xia, Yang Jiang, Yuan-Kun Lee, Dong Liang, Bo Yang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Wei Chen. (2024) Identification and validation of fermented milk-derived osteogenic peptides via molecular docking and osteoblastic cell model. Food Bioscience, [PMID:] [10.1016/j.fbio.2024.103698] |
| 6. Shuli Fan, Xiang Gao, Peng Chen, Xu Li. (2018) Myricetin ameliorates glucocorticoid-induced osteoporosis through the ERK signaling pathway. LIFE SCIENCES, [PMID:29883721] [10.1016/j.lfs.2018.06.006] |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
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