Cetrelimab (anti-PDCD1) - Anticorpo primario, specific to PDCD1, >95%, Human IgG4SP, INHIBITOR of Programmed cell death protein 1 inhibitor, INHIBITOR of Programmed cell death protein 1 inhibitor

CAS: 2050478-92-5 Cat. No.: Ab179071

GRADE & PURITY Animal Free, Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Umano

Reactive species

Cynomolgus monkey, Umano

Isotype

Human IgG4SP

Conjugation

Unconjugated

Panoramica

Cetrelimab (anti-PDCD1) is a humanized mAb targeting PD-1. Cetrelimab (anti-PDCD1) binds PD-1 (Kd=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and PD-L2 (IC50s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab (anti-PDCD1) stimulates peripheral T cells, increases IFN-γ, IL-2, TNF-α level and inhibits tumor growth in vivo.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Specifications

Product Name

Cetrelimab (anti-PDCD1) - Anticorpo primario, specific to PDCD1, >95%, Human IgG4SP, INHIBITOR of Programmed cell death protein 1 inhibitor

Sinonimi

CD279 antibody | CD279 antigen antibody | hPD 1 antibody | hPD l antibody | hPD-1 antibody | hSLE1 antibody | PD 1 antibody | PD-1 antibody | PD1 antibody | PDCD 1 antibody | PDCD1 antibody | PDCD1_HUMAN antibody | Programmed cell death 1 antibody | Progr

Specifiche e purezza

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Specie ospite

Umano

Specificità

PDCD1

Coniugazione

Unconjugated

Grado

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Tipo di azione

INHIBITOR

Meccanismo d'azione

INHIBITOR of Programmed cell death protein 1 inhibitor

Isotipo

Human IgG4SP

Tipo di catena leggera

kappa

SDS-PAGE

26.7 kDa (Light Chain) & 53.2 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions.

Metodo di purificazione

Protein A purified

La purezza

>95%

Concentrazione

See COA

CAS

2050478-92-5

Product Line

Prodotti biologici

Stoccaggio e spedizione

Forma

Liquid

Condizioni di conservazione di stoccaggio

Store at -80°C,Avoid repeated freezing and thawing

Spedito in

Dry ice packs + Cold packs

Stabilità e conservazione

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Immagini

Flow Cytometry: Cetrelimab (anti-PDCD1) (Ab179071)

Cetrelimab (anti-PDCD1) (Ab179071) - Flow Cytometry
Flow Cytometry analysis of 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated MOLT-4 cells (24h) labelling PDCD1 (red) with Cetrelimab (anti-PDCD1) (Ab179071). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Cetrelimab (anti-PDCD1) (Ab179071)

Cetrelimab (anti-PDCD1) (Ab179071) - SEC
The purity of Cetrelimab (anti-PDCD1) (Ab179071) is more than 95% verified by HPLC.

Obiettivi associati (umani)

PDCD1 Tclin Programmed cell death protein 1 (0 Activities)

Discover Target: PDCD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDCD1 Tclin Programmed cell death protein 1 (14 Activities)

Discover Target: PDCD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione