Odronextamab (anti-CD20&CD3) - Anticorpo primario, specific to MS4A1&CD3E, Human IgG4SP, BINDING AGENT of B-lymphocyte antigen CD20 binding agent, BINDING AGENT of B-lymphocyte antigen CD20 binding agent

CAS: 1801338-64-6 Cat. No.: Ab182836

GRADE & PURITY Animal Free, Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥90%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Umano

Reactive species

Umano

Isotype

Human IgG4SP

Conjugation

Unconjugated

Panoramica

Odronextamab (anti-CD20&CD3) is a hinge-stabilised, fully human IgG4-based CD20 × CD3 bispecific antibody that binds CD3 on T cells and CD20 on B cells.
Purity
≥ 90% (SDS-PAGE&SEC)
Endotoxin Level
≤ 1.0EU/mg

Specifications

Product Name

Odronextamab (anti-CD20&CD3) - Anticorpo primario, specific to MS4A1&CD3E, Human IgG4SP, BINDING AGENT of B-lymphocyte antigen CD20 binding agent

Sinonimi

APY antibody | ATOPY antibody | B lymphocyte antigen CD20 antibody | B Lymphocyte Cell Surface Antigen B1 antibody | B-lymphocyte antigen CD20 antibody | B-lymphocyte cell-surface antigen B1 antibody | B-lymphocyte surface antigen B1 antibody | B1 antibod

Specifiche e purezza

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA

Specie ospite

Umano

Specificità

MS4A1&CD3E

Coniugazione

Unconjugated

Grado

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Tipo di azione

BINDING AGENT

Meccanismo d'azione

BINDING AGENT of B-lymphocyte antigen CD20 binding agent

Isotipo

Human IgG4SP

Tipo di catena leggera

kappa

SDS-PAGE

145.32 kDa

Metodo di purificazione

Protein A purified

Concentrazione

See COA

CAS

1801338-64-6

Product Line

Prodotti biologici

Stoccaggio e spedizione

Condizioni di conservazione di stoccaggio

Store at -80°C,Avoid repeated freezing and thawing

Spedito in

Dry ice packs + Cold packs

Stabilità e conservazione

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Immagini

Flow Cytometry: Odronextamab (anti-CD20&CD3) (Ab182836)

Odronextamab (anti-CD20&CD3) (Ab182836) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD20&CD3 with Odronextamab (anti-CD20&CD3) (Ab182836) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Odronextamab (anti-CD20&CD3) (Ab182836)

Odronextamab (anti-CD20&CD3) (Ab182836) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD20&CD3 (red) with Odronextamab (anti-CD20&CD3) (Ab182836) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Odronextamab (anti-CD20&CD3) (Ab182836)

Odronextamab (anti-CD20&CD3) (Ab182836) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD20&CD3 (red) with Odronextamab (anti-CD20&CD3) (Ab182836) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Odronextamab (anti-CD20&CD3) (Ab182836)

Odronextamab (anti-CD20&CD3) (Ab182836) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD3 (red) with Odronextamab (anti-CD20&CD3) (Ab182836) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: Odronextamab (anti-CD20&CD3) (Ab182836)

Odronextamab (anti-CD20&CD3) (Ab182836) - ELISA
Immobilized Recombinant Hu-CD20-VLP protein at 2.0 μg/mL can bind Odronextamab (anti-CD20&CD3) (Ab182836) with the EC₅₀ of 45.99 ng/mL.

SEC: Odronextamab (anti-CD20&CD3) (Ab182836)

Odronextamab (anti-CD20&CD3) (Ab182836) - SEC
The purity of Odronextamab (anti-CD20&CD3) (Ab182836) is more than 95% verified by HPLC.

Domande frequenti

What does Animal Free mean?

Animal Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

What does Carrier Free mean?

Carrier Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

How should this product be stored?

Store at ?80 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1801338-64-6.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Which species reactivity has this antibody been validated against?

Validated reactivity is listed on the PDP and on each lot's datasheet. We validate against the most commonly tested species for the target (Odronextamab (anti-CD20&CD3)); cross-reactivity in untested species may exist but is not guaranteed. Contact technical support for specific species inquiries.