Sunitinib - Moligand™, ≥99% , Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of fms related receptor tyrosine kinase 4;Inhibitor of kinase insert domain receptor;Inhibitor of KIT proto-oncoge, Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of fms related receptor tyrosine kinase 4;Inhibitor of kinase insert domain receptor;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase;I

CAS: 557795-19-4 Cat. No.: S126061 Fórmula: C₂₂H₂₇FN₄O₂ Peso molecular: 398.47 Número CE: 111-194-2 PubChem CID: 5329102

GRADE & PURITY Moligand™, ≥99%

Synonyms

1H-Pyrrole-3-carboxamide,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl- | D08552 | C22H27FN4O2 | N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1 pound not2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2 pound not4-dimethyl-1H-pyrrole-3-carboxamide | SC

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

Specifications

Sinónimos

1H-Pyrrole-3-carboxamide,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl- | D08552 | C22H27FN4O2 | N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1 pound not2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2 pound not4-dimethyl-1H-pyrrole-3-carboxamide | SC

Especificações e pureza

Moligand™, ≥99%

Mecanismos bioquímicos e fisiológicos

IC50 Value: 2 nM (PDGFRβ); 80 nM (VEGFR2) [1] Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. in vitro: Sunitinib is a potent ATP-competitive inhibitor of VEGFR2 (Flk1)

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Mecanismo de ação

Inhibitor of fibroblast growth factor receptor 1;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of fms related receptor tyrosine kinase 4;Inhibitor of kinase insert domain receptor;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase;I

Pureza

≥99%

Nomes e identificadores

Pubchem Sid

488195369

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488195369

Sorrisos canónicos

CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C

IUPAC Name

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

InChIKey

WINHZLLDWRZWRT-ATVHPVEESA-N

INCHI

1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-

SMILES isoméricas

CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C

PubChem CID

5329102

Número UN

2811

Grupo de embalagem

III

Peso molecular

398.47

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Indoles and derivatives
      • Subclass Indolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Indoles and derivatives
• Subclass: Indolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Indolines
• Alternative Parents: Pyrrole carboxamides Substituted pyrroles Aryl fluorides Benzenoids Vinylogous amides Heteroaromatic compounds Trialkylamines Secondary carboxylic acid amides Amino acids and derivatives Lactams Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organofluorides Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Dihydroindole - Pyrrole-3-carboxamide - Pyrrole-3-carboxylic acid or derivatives - Aryl fluoride - Aryl halide - Substituted pyrrole - Benzenoid - Pyrrole - Heteroaromatic compound - Vinylogous amide - Tertiary amine - Amino acid or derivatives - Secondary carboxylic acid amide - Tertiary aliphatic amine - Carboxamide group - Lactam - Azacycle - Carboxylic acid derivative - Amine - Organofluoride - Organohalogen compound - Organonitrogen compound - Organopnictogen compound - Organooxygen compound - Organic oxide - Carbonyl group - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as indolines. These are compounds containing an indole moiety, which consists of pyrrolidine ring fused to benzene to form 2,3-dihydroindole.
• External Descriptors: monocarboxylic acid amide - pyrroles

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

GJD4 Tdark Gap junction delta-4 protein (0 Activities)

Discover Target: GJD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DLK1 Tchem Protein delta homolog 1 (2 Activities)

Discover Target: DLK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSF1R Tclin Macrophage colony-stimulating factor 1 receptor (3 Activities)

Discover Target: CSF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DAPK3 Tchem Death-associated protein kinase 3 (3 Activities)

Discover Target: DAPK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RET Tclin Proto-oncogene tyrosine-protein kinase receptor Ret (11 Activities)

Discover Target: RET

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STK17A Tchem Serine/threonine-protein kinase 17A (5 Activities)

Discover Target: STK17A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STK10 Tchem Serine/threonine-protein kinase 10 (3 Activities)

Discover Target: STK10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STK33 Tchem Serine/threonine-protein kinase 33 (3 Activities)

Discover Target: STK33

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STK4 Tchem Serine/threonine-protein kinase 4 (3 Activities)

Discover Target: STK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT4 Tclin Vascular endothelial growth factor receptor 3 (3 Activities)

Discover Target: FLT4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IRAK1 Tchem Interleukin-1 receptor-associated kinase 1 (2 Activities)

Discover Target: IRAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 (38 Activities)

Discover Target: FLT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GAK Tchem Cyclin-G-associated kinase (3 Activities)

Discover Target: GAK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR1 Tclin Fibroblast growth factor receptor 1 (1 Activities)

Discover Target: FGFR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta (3 Activities)

Discover Target: CSNK1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITK Tclin Tyrosine-protein kinase ITK/TSK (3 Activities)

Discover Target: ITK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MERTK Tchem Tyrosine-protein kinase Mer (3 Activities)

Discover Target: MERTK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNIK Tchem TRAF2 and NCK-interacting protein kinase (6 Activities)

Discover Target: TNIK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDGFRA Tclin Platelet-derived growth factor receptor alpha (4 Activities)

Discover Target: PDGFRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PHKG1 Tchem Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (3 Activities)

Discover Target: PHKG1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDGFRB Tclin Platelet-derived growth factor receptor beta (15 Activities)

Discover Target: PDGFRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MINK1 Tchem Misshapen-like kinase 1 (2 Activities)

Discover Target: MINK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RPS6KA2 Tchem Ribosomal protein S6 kinase alpha-2 (3 Activities)

Discover Target: RPS6KA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K19 Tchem Mitogen-activated protein kinase kinase kinase 19 (2 Activities)

Discover Target: MAP3K19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LCK Tclin Tyrosine-protein kinase Lck (1 Activities)

Discover Target: LCK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP4K1 Tchem Mitogen-activated protein kinase kinase kinase kinase 1 (3 Activities)

Discover Target: MAP4K1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LRRK2 Tchem Leucine-rich repeat serine/threonine-protein kinase 2 (2 Activities)

Discover Target: LRRK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK1 Tclin Tyrosine-protein kinase JAK1 (2 Activities)

Discover Target: JAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMP2K Tchem BMP-2-inducible protein kinase (3 Activities)

Discover Target: BMP2K

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Tchem Uncharacterized protein FLJ45252 (1 Activities)

Explore this target

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT1 Tclin Vascular endothelial growth factor receptor 1 (5 Activities)

Discover Target: FLT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 (33 Activities)

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AAK1 Tchem AP2-associated protein kinase 1 (4 Activities)

Discover Target: AAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKAA1 Tclin 5'-AMP-activated protein kinase catalytic subunit alpha-1 (3 Activities)

Discover Target: PRKAA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHEK2 Tchem Serine/threonine-protein kinase Chk2 (3 Activities)

Discover Target: CHEK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AXL Tchem Tyrosine-protein kinase receptor UFO (5 Activities)

Discover Target: AXL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ULK1 Tchem Serine/threonine-protein kinase ULK1 (2 Activities)

Discover Target: ULK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ULK2 Tchem Serine/threonine-protein kinase ULK2 (2 Activities)

Discover Target: ULK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLK1 Tchem Dual specificity protein kinase CLK1 (4 Activities)

Discover Target: CLK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLK2 Tchem Dual specificity protein kinase CLK2 (4 Activities)

Discover Target: CLK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLK4 Tchem Dual specificity protein kinase CLK4 (4 Activities)

Discover Target: CLK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KIT Tclin Mast/stem cell growth factor receptor Kit (27 Activities)

Discover Target: KIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (5 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PAK3 Tchem Serine/threonine-protein kinase PAK 3 (3 Activities)

Discover Target: PAK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MYLK3 Tchem Myosin light chain kinase 3 (1 Activities)

Discover Target: MYLK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MYLK Tchem Myosin light chain kinase, smooth muscle (1 Activities)

Discover Target: MYLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

Discover Target: ABL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

Discover Target: NR3C1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

INSR Tclin Insulin receptor (5558 Activities)

Discover Target: INSR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PGR Tclin Progesterone receptor (8562 Activities)

Discover Target: PGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

Discover Target: ADRB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

Discover Target: CHRM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)

Discover Target: ADRB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

Discover Target: HTR1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

Discover Target: ADRA2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AR Tclin Androgen Receptor (11781 Activities)

Discover Target: AR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RARA Tclin Retinoic acid receptor alpha (1324 Activities)

Discover Target: RARA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

Discover Target: CHRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)

Discover Target: TOP2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IMPDH2 Tclin Inosine-5'-monophosphate dehydrogenase 2 (1326 Activities)

Discover Target: IMPDH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD2 Tclin Dopamine D2 receptor (23596 Activities)

Discover Target: DRD2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)

Discover Target: GABRA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOA Tclin Monoamine oxidase A (11911 Activities)

Discover Target: MAOA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)

Discover Target: CNR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD1 Tclin Dopamine D1 receptor (9720 Activities)

Discover Target: DRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD4 Tchem Dopamine D4 receptor (7907 Activities)

Discover Target: DRD4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

Discover Target: PTGS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

Discover Target: SLC6A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH2 Tclin Histamine H2 receptor (5428 Activities)

Discover Target: HRH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)

Discover Target: HTR2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)

Discover Target: HTR2C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)

Discover Target: AVPR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

Discover Target: ADORA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)

Discover Target: AGTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A4 Tclin Serotonin transporter (12625 Activities)

Discover Target: SLC6A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

Discover Target: ADRA1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

Discover Target: PTGS2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH1 Tclin Histamine H1 receptor (7573 Activities)

Discover Target: HRH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRM1 Tclin Mu opioid receptor (19785 Activities)

Discover Target: OPRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD3 Tclin Dopamine D3 receptor (14368 Activities)

Discover Target: DRD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)

Discover Target: AVPR1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRD1 Tclin Delta opioid receptor (15096 Activities)

Discover Target: OPRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRK1 Tclin Kappa opioid receptor (16155 Activities)

Discover Target: OPRK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)

Discover Target: HTR3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A3 Tclin Dopamine transporter (10535 Activities)

Discover Target: SLC6A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)

Discover Target: GRIN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARA Tclin Peroxisome proliferator-activated receptor alpha (9197 Activities)

Discover Target: PPARA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 Activities)

Discover Target: CACNA1C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

Discover Target: PDE3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 Activities)

Discover Target: SLC29A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 Activities)

Discover Target: PDGFRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Cdk4 Cyclin-dependent kinase 4 (3 Activities)

Discover Target: Cdk4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Htr7 Serotonin 7 (5-HT7) receptor (19 Activities)

Discover Target: Htr7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Npy1r Neuropeptide Y receptor type 1 (8 Activities)

Discover Target: Npy1r

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cckar Cholecystokinin A receptor (90 Activities)

Discover Target: Cckar

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIK3CA PI3-kinase p110-alpha subunit (51 Activities)

Discover Target: PIK3CA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pde4d Phosphodiesterase 4D (4 Activities)

Discover Target: Pde4d

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pygl Liver glycogen phosphorylase (81 Activities)

Discover Target: Pygl

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Prkcd Protein kinase C delta (192 Activities)

Discover Target: Prkcd

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Prkcb Protein kinase C beta (2 Activities)

Discover Target: Prkcb

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Abcb1b P-glycoprotein 1 (174 Activities)

Discover Target: Abcb1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Fgfr4 Fibroblast growth factor receptor 4 (138 Activities)

Discover Target: Fgfr4

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Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)

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Camk2g CaM kinase II gamma (1 Activities)

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Tec Tyrosine-protein kinase TEC (25 Activities)

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Ulk3 ULK3 kinase (23 Activities)

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Plasmodium falciparum (966862 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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dengue virus type 4 (242 Activities)

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West Nile virus (623 Activities)

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Hepatitis C virus (23859 Activities)

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BaF3 (4657 Activities)

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CHO (4503 Activities)

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Vero (26788 Activities)

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Beta-TC6 (562 Activities)

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H4 (48 Activities)

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4T1 (1737 Activities)

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B16-F10 (4610 Activities)

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Cynomolgus monkey (4946 Activities)

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AIRC Multifunctional protein ADE2 (8 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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dengue virus type 1 (258 Activities)

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dengue virus type 2 (2400 Activities)

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dengue virus type 3 (207 Activities)

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Plasma (328 Activities)

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pknB Serine/threonine-protein kinase pknB (356 Activities)

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CDPK1 Calcium-dependent protein kinase 1 (793 Activities)

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CRK2 Cell division control protein 2 homolog (194 Activities)

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Kit Mast/stem cell growth factor receptor Kit (47 Activities)

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Cacna1c Voltage-gated L-type calcium channel (1164 Activities)

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Septin9 Septin-9 (1 Activities)

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Acadvl Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (1 Activities)

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Liver microsome (341 Activities)

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Chorioallantoic membrane (375 Activities)

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Thoracic aorta (838 Activities)

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Grk2 Beta-adrenergic receptor kinase 1 (13 Activities)

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Scyl1 N-terminal kinase-like protein (54 Activities)

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Chikungunya virus (1339 Activities)

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Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: 25°C: DMSO
• Peso molecular: 398.500 g/mol
• XLogP3: 2.600
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 398.212 Da
• Monoisotopic Mass: 398.212 Da
• Topological Polar Surface Area: 77.200 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 636.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Application Protocols

No tested application protocols or recommended dilutions are provided in the Product Data for this item.

• Not specified for this item; refer to CoA/Spec Sheet.

General guidance for research use (non-validated, literature-informed):

• Prepare 10–50 mM DMSO stock solutions and store at -20°C protected from light.
• For biochemical kinase assays: perform serial dilutions in assay buffer to generate concentration–response curves; maintain constant DMSO % across wells.
• For cell-based assays: titrate across a suitable range with low final DMSO (commonly ≤0.1–0.2% v/v), include vehicle controls, and assess pathway readouts after appropriate incubation times.
• Always confirm solubility and absence of precipitation visually and, if possible, analytically.

Biological Roles

Research-context description (literature; no clinical claims):

• Modality: ATP-competitive small-molecule inhibitor used as a chemical probe of receptor tyrosine kinase signaling.
• Representative kinase coverage reported in the literature: VEGFRs, PDGFRs, KIT, FLT3, CSF1R, and RET among others. Potency and selectivity depend on assay conditions and isoform.
• Mechanistic note: binds to the kinase ATP site in a DFG-in/off-like conformation typical for indolinone-class inhibitors, stabilizing inactive states and suppressing downstream phosphorylation events.
• Cellular studies: utilized to modulate angiogenic and proliferative signaling pathways; enables target validation, pathway dissection, and phenotypic screening. Researchers often benchmark responses such as phospho-ERK/AKT readouts, receptor autophosphorylation, or gene-expression signatures.
• ADME-relevant properties (general): lipophilicity and a basic amine support membrane permeability; ionization state influences solubility and distribution in biological systems.
• Off-target considerations: multi-kinase profile can confound single-target attribution; orthogonal controls and inactive analogs are recommended to deconvolute mechanism.
• Usage caveats: concentration-responsive effects can reflect polypharmacology; employ concentration–response curves and time-course designs, plus counter-screens on unrelated kinases or assays.

Note: Specific activity data and selectivity for this item are not provided; consult primary literature and generate internal QC profiles for your assay conditions.

Buffer Applications

This compound is not a buffering agent and is not typically used to prepare pH buffer systems. For experimental work, dissolve in a suitable organic solvent (commonly DMSO) and dilute into your assay buffer. See “Solvent Selection” and “Reaction Conditions” for practical preparation and dilution guidance.

Green Alternatives

As a research ligand, Sunitinib itself is not replaceable by a “greener” reagent in assays requiring its specific target engagement. However, greener practices can be applied to its handling and formulation.

• Solvent considerations:
  • Preferred: minimize DMSO usage by preparing higher-concentration master stocks and performing serial dilutions to low final percentages.
  • Alternatives for certain workflows: ethanol or PEG400/aqueous cosolvent systems may reduce reliance on DMSO in large-scale screenings if assay-compatible.
• Process and waste minimization:
  • Use micro-aliquots to avoid repeated freeze–thaw and disposal of partially degraded solutions.
  • Adopt high-throughput liquid handling to reduce dead volumes and plastic waste.
• Comparison (general):
  • DMSO vs EtOH: DMSO provides superior solubility and stability but is less volatile; EtOH is more volatile and sometimes better for rapid evaporation steps—tradeoff in solubility for lipophilic bases.
  • DMSO vs PEG400: PEG400 can lower VOC emissions but may alter viscosity and assay performance; validate carefully.
• Procurement and storage:
  • Cold-chain shipping (as provided) supports stability, reducing repeat orders and waste from degradation.

Pharmaceutical Uses

No therapeutic or clinical claims are made for this catalog item. Research-use-only context:

• Role in pharmaceutical R&D (general):
  • Employed as a reference standard or control compound in kinase assay development, screening cascades, PK/PD method development, and LC–MS analytical qualification.
  • Useful in selectivity profiling panels to benchmark assay performance and instrument response.
• Formulation studies (preclinical research):
  • Investigators may explore cosolvent systems, pH adjustment, and solubilizers (e.g., cyclodextrins, PEGs) to enable in vitro and ex vivo studies. Validate compatibility with biological systems and analytical methods.
• Pharmacopeial status/specifications: Not specified for this item; refer to CoA/Spec Sheet if compendial information is available for the specific form.
• Salt/counterion note:
  • This listing does not specify salt form; identity (free base vs salt) and any residual counterions should be confirmed on the CoA, as these influence solubility and handling.

Physical Properties

Item-specific values are not provided in the Product Data; consult the CoA/Spec Sheet for release-specific specifications.

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight (item-specific): Not specified for this item; refer to CoA/Spec Sheet. (Literature for free base ~398.48 g/mol.)
• Solubility (literature, qualitative):
  • DMSO: high solubility; routinely prepared as concentrated stock solutions (e.g., 10–50 mM).
  • Alcohols (MeOH, EtOH): moderate solubility.
  • Aqueous buffers: low intrinsic solubility at neutral pH; solubility can improve with cosolvents or acidification (due to basic tertiary amine).
• Ionization/acid–base (literature, qualitative): contains a basic tertiary amine that can be protonated under acidic conditions, improving water solubility of the protonated form.
• Partitioning (literature, qualitative): lipophilic small molecule consistent with membrane-permeable kinase ligands; expect elevated logP/logD relative to polar probes.
• Melting point, boiling point, density, refractive index, pKa, logP: Not specified for this item; refer to CoA/Spec Sheet. Where needed, consult primary literature or databases for general reference values; do not use literature values as product specifications.

Quality and Grades

• Grade/Purity listed: Moligand™.
• Interpretation (general explanation of the Moligand™ concept):
  • Moligand™ denotes a small-molecule ligand grade suitable for screening, profiling, and chemical biology applications where well-characterized identity and purity are important for reproducible assay performance.
  • Typical expectations for such a grade include high purity by LC/UV (and/or LC/MS), tight identity confirmation, and suitability for preparing DMSO stock solutions for biochemical or cell-based assays. Exact specifications for this lot are Not specified for this item; refer to CoA/Spec Sheet.
• Stabilizers/inhibitors: Not specified for this item; refer to CoA/Spec Sheet. If present, stabilizers would be declared on the CoA.
• UV/LC behavior: Not specified for this item; refer to CoA/Spec Sheet. (Literature note: indolinone-based chromophores usually exhibit strong UV absorbance, facilitating HPLC monitoring.)
• What this means for your work:
  • Expect batch-to-batch consistency suitable for screening and SAR studies.
  • For quantitative pharmacology or reference-standard use, verify purity, residual solvents, and counterions against the supplied CoA.
• Additional quality remarks specific to this listing:
  • The product is shipped cold and recommended for storage at -20°C, supporting long-term stability of the solid and concentrated DMSO stocks. Exact shelf-life/retention times are CoA-dependent.

Reaction and Applications

This product is supplied as a bioactive small-molecule ligand rather than as a general synthetic reagent. Accordingly, it is not typically used as a solvent or stoichiometric reagent in classical organic reactions.

Where relevant to discovery chemistry and probe development (general, literature-informed):

• Assay applications: widely employed as a reference tool compound in kinase biochemistry and cell signaling studies to interrogate tyrosine kinase pathways. Use as a positive control in target engagement or pathway inhibition readouts is common in research settings.
• Derivatization potential:
  • The tertiary amine can be transformed to quaternary ammonium salts (e.g., to create permanently charged analogs for imaging/MS applications).
  • The scaffold has positions that tolerate linker installation for affinity probes (e.g., photoaffinity or biotinylated derivatives) in chemoproteomics; however, such modifications require medicinal chemistry optimization to retain binding.
• Assay preparation notes:
  • Prepare concentrated DMSO stocks; aliquot to avoid freeze–thaw.
  • Protect from strong light and prolonged ambient exposure; check for precipitation after aqueous dilution and gently warm or sonicate if needed.
• Not commonly involved in named reactions as a reagent. For synthetic route development to the scaffold, see “Synthetic Utility.”

Reaction Conditions

Because this product is used as a research ligand rather than as a reaction reagent, “reaction conditions” are best interpreted as preparation and handling conditions for biological experiments.

• Stock solution preparation (general best practice):
  • Dissolve in anhydrous DMSO to 10–50 mM. Vortex thoroughly and, if needed, gently warm (≤40°C) or brief sonication to ensure complete dissolution.
  • Filter through 0.22 µm PTFE if particulate persists.
  • Aliquot into amber vials or PCR tubes to avoid repeated freeze–thaw cycles.
• Working solution dilution:
  • Add DMSO stocks to pre-warmed assay buffers or media with vigorous mixing to a final DMSO concentration typically ≤0.1–0.5% v/v (assay-dependent).
  • If precipitation occurs, increase temperature slightly, slow the addition, or incorporate a small amount of cosolvent (EtOH, PEG400) compatible with the assay.
• Stability considerations:
  • Protect from light and air exposure during extended incubations. Prepare fresh dilutions daily when possible.
  • For long incubations in aqueous media, monitor for adsorption to plastics; low-bind labware can help.
• Analytical confirmation:
  • Verify concentration by UV-Vis or LC–MS when critical; indolinone chromophores typically afford strong UV signals in the 230–280 nm range (literature, general).

Note: No item-specific kinetic or degradation data are provided; consult SDS/CoA and perform internal stability checks under your conditions.

Safety and Handling

Hazard details are not provided in the Product Data. Always review the item-specific SDS before use.

• GHS/CLP information (item-specific):
  • Signal word, hazard statements, pictograms, classification: Not specified for this item; refer to SDS.
• General laboratory precautions (good practice for kinase-targeting small molecules):
  • Avoid inhalation, ingestion, and skin contact. Handle inside a chemical fume hood or ventilated enclosure when weighing/aliquoting powders or preparing concentrated solutions.
  • PPE: lab coat, nitrile gloves (double-gloving advisable for concentrated DMSO solutions), safety glasses or splash goggles.
  • First aid (general): in case of skin contact, wash with soap/water; eye contact, rinse with water for several minutes; inhalation, move to fresh air; ingestion, seek medical attention. Refer to SDS for detailed guidance.
• Handling notes:
  • Use amber containers or minimize light exposure; many indolinone-based chromophores are light-sensitive to some extent.
  • Avoid generating dust/aerosols. For solution handling, cap promptly and wipe external surfaces to prevent cross-contamination.
• Incompatibilities (general): strong oxidizers and strong acids/bases may degrade organic small molecules; avoid reactive acylating/alkylating environments unless intended.
• Waste: collect solutions and contaminated disposables as halogen-free organic waste per institutional and local regulations.
• Transport and shipping: Product Data indicates shipment on ice packs within an ice chest; keep cold upon receipt and store as directed.

Solvent Selection

Sunitinib is a lipophilic, basic small molecule; solvent choice is driven by solubility, stability, and intended application.

• Practical solvent choices (literature-informed, general):
  • DMSO: preferred for concentrated stocks (e.g., 10–50 mM) due to high solubility and assay compatibility at low final percentages.
  • Methanol or ethanol: acceptable for intermediate concentrations; often diluted into aqueous buffers with surfactants or cosolvents.
  • Aqueous buffers: poor solubility at neutral pH; protonation under mildly acidic conditions (e.g., addition of small amounts of HCl) can improve solubility, but consider assay tolerance.
  • PEG400, propylene glycol: useful cosolvents for formulation studies where DMSO must be minimized.
• Polarity/miscibility (general):
  • Sunitinib stocks in DMSO are miscible upon dilution into most buffered saline systems; keep DMSO final concentration low (commonly ≤0.1–0.5%) to avoid biological assay artifacts.
• Selection guidance:
  • Biochemical assays: DMSO master stocks, serially diluted in assay buffer immediately before use.
  • Cell-based assays: minimize DMSO (<0.1–0.2% v/v if possible) and consider dilution into serum-containing media to limit precipitation; pre-warm and vortex.
  • Physical chemistry studies: use anhydrous solvents for precise measurements; control pH/ionization state when comparing spectra or partitioning.
• Tip: Filter or centrifuge working solutions if turbidity appears upon aqueous dilution; adjust dilution rate, temperature, or cosolvent fraction to maintain clarity.

Storage and Reconstitution

• Storage conditions (from Product Data): Store at -20°C. Shipments are made in an ice chest with ice pads; keep cold upon receipt.
• Light/moisture: Store in a dry, dark place. Use amber vials for solutions and minimize headspace to limit oxidative exposure.
• Reconstitution (general best practice for this scaffold):
  • Dissolve the solid in anhydrous DMSO to prepare a concentrated stock (e.g., 10–50 mM). Mix thoroughly; gentle warming or short sonication may assist dissolution.
  • Optionally, prepare hydrochloride salt in situ for aqueous applications by adding a minimal volume of dilute HCl after DMSO dissolution and subsequent dilution—only if compatible with your assay.
• Aliquoting: Dispense single-use aliquots to avoid repeated freeze–thaw. Label with concentration, date, and lot.
• Freeze–thaw guidance: Avoid repeated cycles. Thaw on ice or at room temperature, mix, and promptly return unused aliquots to -20°C.
• Stability notes:
  • Working aqueous solutions are best prepared fresh. Inspect for precipitation or color change; discard if degradation is suspected.
  • Item-specific shelf life and retest dates: Not specified for this item; refer to CoA/Spec Sheet.
• Research Use Only: as stated in Product Data.

Structure and Identity

Sunitinib is a heteroaromatic small molecule typically classified as an indolinone-derived, ATP-competitive kinase ligand.

• Item-specific registry data from Product Data:
  • CAS: 557795-19-4
  • InChIKey: Not specified for this item; refer to CoA/Spec Sheet.
  • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• Literature identity (for general reference; not item-specific specifications):
  • Common name: Sunitinib (free base)
  • Molecular formula: C22H27FN4O2 (literature)
  • Molecular weight: ~398.48 g/mol (literature, free base)
  • Representative InChIKey: HLESAWHHMQBBED-UHFFFAOYSA-N (literature)
• Structural features (literature description):
  • Core: 2-oxindole (indolinone) scaffold fused to a benzene ring, providing a planar heteroaromatic pharmacophore.
  • Substituents: a 4-fluorophenyl group bearing a dimethylcarbamoyl moiety; a diethylaminoethyl side chain attached to the indolinone nitrogen.
  • Functional groups: secondary amide/indolinone carbonyl, tertiary amide (carbamoyl), tertiary aliphatic amine (diethylamino), aryl fluoride.
  • No stereocenters; expected as a single achiral entity.
• 2D structure in words: an indolinone ring system (lactam) bearing at C-3 a substituted anilide-like appendage and at N-1 a 2-(diethylamino)ethyl chain; the anilide contains a para-fluoro phenyl capped with a dimethylcarbamoyl group.

Note: Identity parameters not listed in Product Data should be confirmed against the item’s CoA/Spec Sheet for release-specific verification.

Synthetic Utility

Sunitinib is supplied as a finished bioactive scaffold rather than a building block; it is not typically used as a synthon in routine organic synthesis. Nevertheless, medicinal and chemical biology programs sometimes adapt the scaffold for probe development.

• Functional group handles (literature description):
  • Tertiary aliphatic amine (diethylaminoethyl) amenable to quaternization or linker attachment via acylation/alkylation after appropriate protection/manipulation.
  • Amide/lactam (indolinone) and tertiary amide (carbamoyl) embedded in the scaffold; generally less reactive without prior activation.
  • Aromatic positions that tolerate substitution in SAR studies, though regioselective modification requires de novo synthesis routes.
• Typical transformations in probe design:
  • Installation of affinity tags (biotin/azide/alkyne) via side-chain elaboration to create pull-down or click-chemistry compatible probes.
  • Photoaffinity labeling groups (diazirines/aryl azides) introduced through linkers attached at peripheral positions with demonstrated SAR tolerance in the literature.
• Caution:
  • Direct late-stage diversification on the purchased compound can be challenging; most modifications are implemented during total or convergent synthesis of analogs to preserve potency.

For procurement as a synthetic intermediate or for custom analog generation, consider route scouting literature for indolinone kinase inhibitors and plan for protecting-group strategies around the amine and lactam.

Target Specificity

Item-specific target data are not provided in the Product Data for this SKU.

• Not specified for this item; refer to CoA/Spec Sheet.

General literature note (for context only; not product specifications): Sunitinib is widely used as a multi-kinase inhibitor tool compound with activity reported against VEGFRs, PDGFRs, KIT, FLT3, and related receptor tyrosine kinases. Actual potency/selectivity depend on assay system, ATP concentration, and isoform, and should be determined experimentally for your setup.

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 557795-19-4, the molecular formula is C22H27FN4O2, and the molecular weight is 398.47 g/mol. InChIKey WINHZLLDWRZWRT-ATVHPVEESA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.