Determine the necessary mass, volume, or concentration for preparing a solution.
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| Abemaciclib inhibe de forma altamente selectiva los complejos CDK4/ciclina D1 (IC50 =2 nmol/L) y CDK6/ciclina D1 (IC50 =10 nmol/L), sin actividad contra otros complejos CDK/ciclina o quinasas relacionadas con el ciclo celular dentro de los rangos nanomolares, excepto para la inhibición de CDK9 con una IC50 al menos cinco veces superior. Además de la actividad dependiente del ciclo celular, abemaciclib es capaz de potenciar la inmunidad antitumoral potenciando la presentación del antígeno tumoral y suprimiendo selectivamente la proliferación de células T reguladoras (Treg) al mismo tiempo. En consonancia con su actividad contra CDK4 y CDK6, abemaciclib inhibe la fosforilación de RB y conduce a la detención G1 en líneas celulares RB-proficientes. In vitro, el tratamiento con abemaciclib produjo un aumento de la activación de las células T humanas y de la expresión de genes de presentación de antígenos en las células MCF-7 de cáncer de mama. | |||
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Clase | Benzimidazoles |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Benzimidazoles |
| Alternative Parents | N-alkylpiperazines Halopyrimidines Aralkylamines Aminopyrimidines and derivatives Aminopyridines and derivatives N-substituted imidazoles Imidolactams Benzenoids Aryl fluorides Heteroaromatic compounds Trialkylamines Azacyclic compounds Organofluorides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Benzimidazole - Aminopyridine - Aminopyrimidine - Halopyrimidine - Aralkylamine - N-alkylpiperazine - Aryl fluoride - Aryl halide - 1,4-diazinane - N-substituted imidazole - Piperazine - Pyridine - Pyrimidine - Imidolactam - Benzenoid - Imidazole - Azole - Heteroaromatic compound - Tertiary amine - Tertiary aliphatic amine - Azacycle - Organohalogen compound - Organofluoride - Organonitrogen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds). |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | Nov 10, 2026 | L190223 | |
| Certificate of Analysis | Sep 01, 2026 | L190223 | |
| Certificate of Analysis | Sep 01, 2026 | L190223 | |
| Certificate of Analysis | Sep 01, 2026 | L190223 | |
| Certificate of Analysis | Oct 13, 2025 | L190223 | |
| Certificate of Analysis | Jun 15, 2024 | L190223 | |
| Certificate of Analysis | Apr 10, 2024 | L190223 | |
| Certificate of Analysis | Dec 10, 2021 | L190223 |
| Solubilidad | insoluble in H2O; ≥4.83 mg/mL in DMSO with gentle warming and ultrasonic; ≥6.34 mg/mL in EtOH with gentle warming |
|---|---|
| Sensibilidad | Light sensitive |
| Peso molecular | 506.600 g/mol |
| XLogP3 | 3.800 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 7 |
| Exact Mass | 506.272 Da |
| Monoisotopic Mass | 506.272 Da |
| Topological Polar Surface Area | 75.000 Ų |
| Heavy Atom Count | 37 |
| Formal Charge | 0 |
| Complexity | 723.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
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