Determine the necessary mass, volume, or concentration for preparing a solution.
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≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -20°C Ships Ice chest + Ice pads,FedEx DG Service Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 48 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Actinomycin D (Dactinomycin) inhibits DNA repair with an IC50 of 0.42 μM. Actinomycin D is an autophagy activator
| ALogP | 3.8 |
|---|
| Sonrisas canónicas | CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C |
|---|---|
| IUPAC Name | 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide |
| InChIKey | RJURFGZVJUQBHK-IIXSONLDSA-N |
| INCHI | 1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1 |
| Isómeros SMILES | C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C |
| Número ONU | 2811 |
| Grupo de embalaje | I |
| Peso molecular | 1255.42 |
| Reaxy-Rn | 1071183 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1071183&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Clase | Peptidomimetics |
| Subclass | Depsipeptides |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Cyclic depsipeptides |
| Alternative Parents | Macrolide lactams Phenoxazines Macrolactams Alpha amino acid esters N-acyl-alpha amino acids and derivatives Benzenoids Dicarboxylic acids and derivatives Pyrrolidines Heteroaromatic compounds Tertiary carboxylic acid amides Vinylogous amides Secondary carboxylic acid amides Lactones Lactams Cyclic ketones Carboxylic acid esters Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organic oxides Primary amines Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Cyclic depsipeptide - Macrolide lactam - Phenoxazine - Alpha-amino acid ester - Macrolactam - N-acyl-alpha amino acid or derivatives - Alpha-amino acid or derivatives - Dicarboxylic acid or derivatives - Benzenoid - Heteroaromatic compound - Vinylogous amide - Pyrrolidine - Tertiary carboxylic acid amide - Amino acid or derivatives - Carboxamide group - Carboxylic acid ester - Lactam - Lactone - Cyclic ketone - Secondary carboxylic acid amide - Oxacycle - Carboxylic acid derivative - Azacycle - Organoheterocyclic compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Amine - Organonitrogen compound - Organooxygen compound - Primary amine - Carbonyl group - Organic oxygen compound - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as cyclic depsipeptides. These are natural or synthetic compounds having sequences of amino and hydroxy carboxylic acid residues (usually α-amino and α-hydroxy acids) connected in a ring. The residues are commonly but not necessarily regularly alternating. |
| External Descriptors | actinomycin |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | Jun 15, 2026 | A113142 | |
| Certificate of Analysis | Jan 19, 2026 | A113142 | |
| Certificate of Analysis | Nov 12, 2025 | A113142 | |
| Certificate of Analysis | Nov 12, 2025 | A113142 | |
| Certificate of Analysis | Nov 12, 2025 | A113142 | |
| Certificate of Analysis | Nov 12, 2025 | A113142 | |
| Certificate of Analysis | Nov 12, 2025 | A113142 | |
| Certificate of Analysis | Feb 21, 2025 | A113142 | |
| Certificate of Analysis | Feb 21, 2025 | A113142 | |
| Certificate of Analysis | Feb 21, 2025 | A113142 | |
| Certificate of Analysis | Feb 21, 2025 | A113142 | |
| Certificate of Analysis | Jun 16, 2022 | A113142 | |
| Certificate of Analysis | Jun 16, 2022 | A113142 | |
| Certificate of Analysis | Jun 16, 2022 | A113142 | |
| Certificate of Analysis | Mar 09, 2022 | A113142 | |
| Certificate of Analysis | Mar 09, 2022 | A113142 | |
| Certificate of Analysis | Mar 09, 2022 | A113142 |
| Solubilidad | Easy to dissolve in chloroform and acetone, slightly soluble in methanol, slightly soluble in ethanol, almost insoluble in water. Exposure to light, heat, or oxidants can all reduce its potency. Odorless and hygroscopic. |
|---|---|
| Sensibilidad | Light sensitive.Hygroscopic. |
| Punto de fusión (°C) | 251-253°C |
| Peso molecular | 1255.400 g/mol |
| XLogP3 | 3.800 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 18 |
| Rotatable Bond Count | 8 |
| Exact Mass | 1254.63 Da |
| Monoisotopic Mass | 1254.63 Da |
| Topological Polar Surface Area | 356.000 Ų |
| Heavy Atom Count | 90 |
| Formal Charge | 0 |
| Complexity | 3030.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 10 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
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| 2. Chen Guo, Mingyi Yu, Jinghua Liu, Zhe Jia, Hui Liu, Shaozhen Zhao. (2023) Molecular mechanism of Wilms tumor 1-associated protein in diabetes-related dry eye disease by mediating m6A methylation modification of lncRNA NEAT1. JOURNAL OF DRUG TARGETING, [PMID:38153328] [10.1080/1061186X.2023.2300682] |
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