Artículos por tema "JAK-STAT"

1. Type Stratification, Signal Transduction, and Effector Networks of the Interferon (IFN) Pathway
   posted this at 24 abr 2026

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   The interferon (IFN) pathway is one of the central signaling systems in host antiviral defense, innate immune activation, and immune homeostasis. Its biological essence is not a single ligand triggering a single receptor, but a multilayered network composed of “pathogen sensing - IFN induction ...
2. Interleukin-29 (IL-29/IFN-λ1): Molecular Features, Signaling Networks, and a Systematic Framework for Research Applications
   posted this at 3 mar 2026

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   Interleukin-29 (IL-29) is a key member of the type III interferon family and is also commonly referred to as interferon lambda 1 (IFN-λ1). IL-29 carries both an “IL-series” designation and a clear interferon-like functional identity.
3. Interleukin Receptor Signaling: Mechanistic Analysis of the JAK-STAT and NF-κB Axes with an Overview of Assays, Experimental Models, and Translational Boundaries
   posted this at 26 ene 2026

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   Interleukins constitute a key group of cytokines produced by immune cells as well as multiple tissue-resident cell types. Their biological effects depend on the assembly of specific receptor complexes and the magnitude of downstream signal transduction, which in turn shapes immune-cell ...