Biotin-PEG3-azide - ≥98% , CAS No.875770-34-6

CAS: 875770-34-6 Cat. No.: B595159 Peso molecular: 444.55

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Biotin-PEG3-azide is PEG derivative containing a biotin group and an azide group. The azide group can react with either alkyne moiety in Cu(I)-catalyzed Click Chemistry reaction or DBCO moiety in copper-free Click Chemistry reaction to form a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules.

Specifications

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: C1C2C(C(S1)CCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-])NC(=O)N2
• IUPAC Name: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]pentanamide
• InChIKey: ZWFOOMQCYIGZBE-ZOBUZTSGSA-N
• INCHI: 1S/C18H32N6O5S/c19-24-21-6-8-28-10-12-29-11-9-27-7-5-20-16(25)4-2-1-3-15-17-14(13-30-15)22-18(26)23-17/h14-15,17H,1-13H2,(H,20,25)(H2,22,23,26)/t14-,15-,17-/m0/s1
• Isómeros SMILES: C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-])NC(=O)N2
• Peso molecular: 444.55
• Reaxy-Rn: 19578611
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19578611&ln=

Mecanismos de acción

Propiedades químicas y físicas

• Punto de fusión (°C): 110 °C
• Peso molecular: 444.600 g/mol
• XLogP3: 0.500
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 17
• Exact Mass: 444.215 Da
• Monoisotopic Mass: 444.215 Da
• Topological Polar Surface Area: 138.000 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 577.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

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3. Zhai Yansheng, Huang Xiaoyan, Zhang Keren, Huang Yuchen, Jiang Yanlong, Cui Jingwei, Zhang Zhe, Chiu Cookson K. C., Zhong Weiye, Li Gang.  (2022)  Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.  Nature Communications,  13  (1): (1-12).  [PMID:35987950] [10.1038/s41467-022-32689-z]

4. Chenchen Ge, Xiong Chen, Dou Wang.  (2024)  An array of femtoliter wells for sensitive detection of copper using click chemistry.  TALANTA,      [PMID:38537359] [10.1016/j.talanta.2024.125973]

5. Yu-Juan Zhan, Chun-Miao Deng, Lin Tang, Shu-Jun Li, Tao-Yang Xu, Xian Wei, Xin-Yi Zhang, Can-Can Zheng, Li Deng, Cui Shao, Zhong-Min Ouyang, Alfred King-Yin Lam, Rong Zhang, Jun Liu, Xing-Yuan Shi, Zhen-Yu Pan, Wei Dai, Ming-Liang He, Simon Law, Xu Li, Xiao-Bing Chen, Cheng Zhou, Bin Li, Wen-Wen Xu.  (2025)  NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA.  Advanced Science,      [PMID:40729677] [10.1002/advs.202502931]

6. Shaoqian Ma, Yantao Hong, Junhan Chen, Jingzhao Xu, Xiaohua Shen.  (2025)  Single-cell nascent transcription reveals sparse genome usage and plasticity.  CELL,      [PMID:41015043] [10.1016/j.cell.2025.09.003]

7. Meichen Li, Yi Peng, Qingqing Xiao, Siyi Chen, Chunjie Zhang, Hongyu Chen, Yue Zhao, Shan Chang, Lu Qiu, Lele Zhang, Xiaoqiang Guo, Qiang Fu.  (2025)  Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.  PHYTOMEDICINE,      [PMID:41447841] [10.1016/j.phymed.2025.157729]