Blasticidin S hydrochloride solution - 10 mg/mL in 20 mM HEPES , CAS No.3513-03-9

CAS: 3513-03-9 Cat. No.: B276563 Peso molecular: 458.9 Número EC: 609-067-6 PubChem CID: 75412545

GRADE & PURITY 10 mg/mL in 20 mM HEPES

Synonyms

(2S,3S,6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride | blasticidin S HCl | (2S,3S,6R)-6-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-[(3S)-3-amino-5-

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.

Specifications

Sinónimos

(2S, 3S, 6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3, 6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride | blasticidin S HCl | (2S, 3S, 6R)-6-(4-amino-2-oxo-1, 2-dihydropyrimidin-1-yl)-3-[(3S)-3-amino-5-

Especificaciones y pureza

10 mg/mL in 20 mM HEPES

Mecanismos bioquímicos y fisiológicos

Broad spectrum amino nucleoside antibiotic agent similar to puromycin . Inhibits protein biosynthesis at both prokaryotic and eukaryotic ribosomes. Also available as a solid .

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Nombres e identificadores

• Sonrisas canónicas: CN(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl
• IUPAC Name: (2S,3S,6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride
• InChIKey: YQXYQOXRCNEATG-NMQKUDMSSA-N
• INCHI: 1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10-,13+,14-;/m0./s1
• Isómeros SMILES: CN(CC[C@@H](CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl
• WGK Alemania: 2
• PubChem CID: 75412545
• Peso molecular: 458.9

Propiedades químicas y físicas

• Solubilidad: Supplied in 20 mM aqueous HEPES, pH 7.0 (10 mg/ml)
• Sensibilidad: light sensitive；heat sensitive；air sensitive
• Índice de refracción: 1.71
• Punto de ebullición (°C): 772.1 °C at 760 mmHg
• Peso molecular: 458.900 g/mol
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 458.179 Da
• Monoisotopic Mass: 458.179 Da
• Topological Polar Surface Area: 213.000 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 795.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Referencias

1. Xinyi Song, Haipeng Rao, Chunchun Huang, Miaoling Huang, Ying Ma, Jingyu Xin, Jiajia Hou, Zhigang Hu, Lingfeng He, Feiyan Pan, Lingdong Yang, Zhigang Guo.  (2025)  P4HB, a novel succinated protein, is essential for fumarate-induced cancer metastasis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40318732] [10.1016/j.ijbiomac.2025.143885]