10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 19 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Cryptotanshinone is aSTAT3inhibitor withIC50of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Cryptotanshinone induces ROS-dependentautophagyand mitoch
In vitro
Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bunge (Danshen), significantly inhibits STAT3-dependent luciferase activity, the STAT3 Tyr705 phosphorylation and the dimerization of STAT3, compared to tanshinone IIA which exhibits no activity. Cryptotanshinone (7 μM) dramatically blocks STAT3 Tyr705 phosphorylation but not STAT3 Ser727 phosphorylation in DU145 cells, and significantly inhibits JAK2 phosphorylation with IC50 of ~5 μM without affecting the phosphorylation of upstream kinases c-Src and EGFR, suggesting the inhibition of STAT3 Tyr705 phosphorylation might due to a direct mechanism probably by binding to the SH2 domain of STAT3. Cryptotanshinone significantly inhibits the proliferation of DU145 prostate cancer cells harboring constitutively active STAT3 with GI50 of 7 μM by blocking STAT3 activity, which leads to the down-regulation of cyclin D1, Bcl-xL, and survivin, subsequently the accumulation in the G0-G1 phase. Cryptotanshinone exhibits less growth inhibitory effect on PC3, LNCaP and MDA-MB-468 cells.
In vivo
Cryptotanshinone administration significantly reduces the body weight and food intake of ob/ob mice (C57BL/6J-Lepob) and diet-induced obese (DIO) mice in a dose-dependent manner. Cryptotanshinone causes noticeably less fat in the adipose tissues, significant reductions of serum triglycerides and cholesterol levels, and 2.5- to 3-fold higher AMPK activity of the skeletal muscles than in the control mice. Oral administration of Cryptotanshinone at 600 mg/kg/day produces dramatic reductions in blood glucose levels of ob/ob mice (C57BL/6J-Lepob), db/db mice (C57BL/KsJ-Leprdb), and ZDF rats, which occur after 3 days and persist over the entirety of the monitoring period.
Cell Data
cell lines：
Concentrations：Dissolved in DMSO, final concentrations ~50 μM
Incubation Time：24 or 48 hours
Powder Purity:≥98%
| Isómeros SMILES | C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C |
|---|---|
| WGK Alemania | 3 |
| RTECS | SF8282645 |
| Peso molecular | 296.36 |
| Beilstein | 5445400 |
| Reaxy-Rn | 288778 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=288778&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 H2416002 | Certificate of Analysis | Jul 01, 2026 | C408350 |
| Solubilidad | Solubility (25°C) In vitro DMSO: 62 mg/mL (199.15 mM); Ethanol: 62 mg/mL (199.15 mM); Water: Insoluble; |
|---|---|
| Rotación específica [α] | -30° (C=0.5,MeOH) |
| Punto de fusión (°C) | 184°C-185°C |
| 1. He Xiangjun, Zhong Zhi, Wang Quan, Jia Zhenmao, Lu Jing, Chen Jianwen, Liu Peiqing. (2023) Pharmacokinetics and tissue distribution of bleomycin-induced idiopathic pulmonary fibrosis rats treated with cryptotanshinone. Frontiers in Pharmacology, [PMID:36969870] [10.3389/fphar.2023.1127219] |
| 2. Min Shi, Ruiyan Zhu, Yi Zhang, Siwei Zhang, Tingyao Liu, Kunlun Li, Shucan Liu, Leran Wang, Yao Wang, Wei Zhou, Qiang Hua, Guoyin Kai. (2022) A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza. METABOLIC ENGINEERING, [PMID:35934177] [10.1016/j.ymben.2022.08.002] |
| 3. Shen Qing, Wang Haixing, Quan Bin, Sun Xiuhua, Wu Guohua, Huang Darong, Wang Qingcheng, Luo Pei. (2022) Rapid quantification of bioactive compounds in Salvia miltiorrhiza Bunge derived decoction pieces, dripping pill, injection, and tablets by polarity-switching UPLC-MS/MS. Frontiers in Chemistry, [PMID:35910733] [10.3389/fchem.2022.964744] |
| 4. Huan Wang, Zhe Liu, Lingnan Guan, Jiankang Li, Siyi Chen, Wenying Yu, Maode Lai. (2020) LYW-6, a novel cryptotanshinone derived STAT3 targeting inhibitor, suppresses colorectal cancer growth and metastasis. PHARMACOLOGICAL RESEARCH, [PMID:31982491] [10.1016/j.phrs.2020.104661] |
| 5. Changping Deng, Xiaolong Hao, Min Shi, Rong Fu, Yao Wang, Yi Zhang, Wei Zhou, Yue Feng, Nokwanda P. Makunga, Guoyin Kai. (2019) Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots. PLANT SCIENCE, [PMID:31084862] [10.1016/j.plantsci.2019.03.007] |
| 6. Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang. (2017) Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs). PHARMACEUTICAL BIOLOGY, [PMID:28466663] [10.3109/13880209.2015.1045621] |
| 7. Man Wang, Wentao Bi, Xiaohua Huang, David Da Yong Chen. (2016) Ball mill assisted rapid mechanochemical extraction method for natural products from plants. JOURNAL OF CHROMATOGRAPHY A, [PMID:27157426] [10.1016/j.chroma.2016.04.044] |
| 8. Shi Min, Zhou Wei, Zhang Jianlin, Huang Shengxiong, Wang Huizhong, Kai Guoyin. (2016) Methyl jasmonate induction of tanshinone biosynthesis in Salvia miltiorrhiza hairy roots is mediated by JASMONATE ZIM-DOMAIN repressor proteins. Scientific Reports, 6 (1): (1-11). [PMID:26875847] [10.1038/srep20919] |
| 9. Min Shi, Xiuqin Luo, Guanhua Ju, Leilei Li, Shengxiong Huang, Tong Zhang, Huizhong Wang, Guoyin Kai. (2016) Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:26753746] [10.1021/acs.jafc.5b04697] |
| 10. Ming Cong, Cui-Min Hu, Yun-Feng Cao, Zhong-Ze Fang, Shu-Hong Tang, Jia-Rui Wang, Jun-Sheng Luo. (2013) Cryptotanshinone and dihydrotanshinone I exhibit strong inhibition towards human liver microsome (HLM)-catalyzed propofol glucuronidation. FITOTERAPIA, [PMID:23333907] [10.1016/j.fitote.2013.01.002] |
| 11. Yong Jiang, Wenjun Ji, Ying Lu, Qin Wang, Linwei Chen. (2025) Integrating Plasma Metabolomics, Network Pharmacology, and Experimental Validation to Investigate the Action Mechanism of Qiangxin Lishui Prescription in Chronic Heart Failure. BIOMEDICAL CHROMATOGRAPHY, 39 (2): (e6065). [PMID:39748248] [10.1002/bmc.6065] |
| 12. Jinghui Li, Yan Kang, Ying Wang, Jiaxin Liu, Yingting Wang, Sitong Liu, Yunxi Bu, Xiangqun Li, Jiahan Xie, Zhibing Wang. (2025) Ionic Liquid-Based Polarity-Adjustable Deep Eutectic Solvent Extraction Followed by High-Performance Liquid Chromatography-Diode-Array Detection for the Determination of Liposoluble Anthraquinones in Salvia miltiorrhiza Bge. Root. JOURNAL OF SEPARATION SCIENCE, 48 (3): (e70116). [PMID:40057467] [10.1002/jssc.70116] |
| 13. Shaoping Ma, Changyong Cai, Xuhong Guo, Zhijian Tan. (2025) Selective separation of tanshinone homologs by biocomposite membranes based on poly(ionic liquids) and natural fibers. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39793843] [10.1016/j.ijbiomac.2025.139568] |
| 14. Jiahui Han Di Jia Hao Yao Ting Lv Xi Xu Xin Ge. (2023) Cryptotanshinone ameliorates hemorrhagic shock-induced liver injury via activating the Nrf2 signaling pathway. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, 61 (2): (109-122). [PMID:37435898] [10.5603/FHC.a2023.0009] |
| 15. Ya-Long Zheng, Yuan Ji, Yan Li, Shuai Yan, Xiao-Rong Ren, Wei Tang, Fang Dai, Bo Zhou. (2024) Identification of tanshinone I as a natural Cu(II) ionophore. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:39613045] [10.1016/j.freeradbiomed.2024.11.049] |
| 16. Nana Gao, Zongyu Huang, Jianjie Xie, Shuang Gao, Biaobiao Wang, Huicong Feng, Cuifen Bao, He Tian, Xia Liu. (2025) Cryptotanshinone alleviates cerebral ischemia reperfusion injury by regulating ferroptosis through the PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:40222690] [10.1016/j.jep.2025.119800] |
| 17. Tao Zhang, Xianmin Shi, Yanjuan Huang, Yujun Gong, Yuanfeng He, Danni Xiao, Shengzhi Wang, Chunshun Zhao. (2025) Oxidized fucoidan-based nanocomposite hydrogel for cryptotanshinone delivery and prevention of postoperative abdominal adhesions. JOURNAL OF CONTROLLED RELEASE, [PMID:40228668] [10.1016/j.jconrel.2025.113733] |
| 18. Hailun Zheng, Xiaoyan Mao, Zhiwei Chen, Linying Wang, Fuxiang Shangguan, Zihao Tao, Jinyao Ye, Weilan Cao, Qing Yao, Lili Yan, Ruijie Chen, Shihui Bao, Longfa Kou. (2025) ATB0,+-targeted nanoparticles trigger STAT3-ferroptosis regulatory axis for enhanced gastric cancer therapy. COLLOIDS AND SURFACES B-BIOINTERFACES, [PMID:40614440] [10.1016/j.colsurfb.2025.114918] |
| 19. Lan-Ting Li, Yan-Xue Zhu, Dong-Mei Zhao, Jin-Le Zhang, Lin-Guo Xia, Rui-Fang Li. (2026) The inhibitory effect of cryptotanshinone on liver cancer by regulating the IRAK1/NF-κB signaling pathway. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, [PMID:42030883] [10.1016/j.bbrc.2026.153816] |
