Cyclosporin A (NSC 290193) - Moligand™, 10mM in DMSO , Cyclophilin A modulator, CAS No.59865-13-3, Cyclophilin A modulator

CAS: 59865-13-3 Cat. No.: C407869 Peso molecular: 1202.61 Beilstein Registry Number: 3647785 Número EC: 611-907-1 PubChem CID: 5284373

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Cyclosporine A, Cyclosporine, Ciclosporin, CsA | no

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Cyclosporin A (NSC 290193) Cyclosporin A (Cyclosporine A, Cyclosporine, Ciclosporin, CsA) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation
In vitro

Cyclosporin A binds to the cyclophilin (immunophilin) in T cells , forms a Cyclophilin-Cyclosporin A complex which the binds to and inhibits calcineurin. Cyclosporin A inhibits calcineurin with IC50 of 7 nM, then blocks the nuclear translocation of NF-AT. Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM.

In vivo

Cyclosporin A is an immunosuppressive agent that is effective following either parenteral or oral administration in mice, rat and guinea pigs. , is clinically used in organ transplantation to prevent rejection.
Cell Data

cell lines：

Concentrations：~100 nM

Incubation Time：1 hr

Powder Purity:≥99%

Specifications

Sinónimos

Cyclosporine A, Cyclosporine, Ciclosporin, CsA | no

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Cyclosporin A (Cyclosporine A, Cyclosporine, Ciclosporin, CsA) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

ANTAGONIST, INHIBITOR, MODULATOR

Mecanismo de acción

Cyclophilin A modulator

Propiedades del producto

• ALogP: 7.5

Nombres e identificadores

• Isómeros SMILES: CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
• WGK Alemania: 3
• RTECS: GZ4120000
• PubChem CID: 5284373
• Peso molecular: 1202.61
• Beilstein: 3647785
• Reaxy-Rn: 3647785

Objetivos asociados (humanos)

FPR1 Tchem fMet-Leu-Phe receptor (0 Activities)

Discover Target: FPR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPID Tchem Peptidyl-prolyl cis-trans isomerase D (0 Activities)

Discover Target: PPID

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCG2 Tchem ATP-binding cassette sub-family G member 2 (0 Activities)

Discover Target: ABCG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC10A1 Tclin Sodium/bile acid cotransporter (0 Activities)

Discover Target: SLC10A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPIA Tclin Peptidyl-prolyl cis-trans isomerase A (0 Activities)

Discover Target: PPIA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro
• Rotación específica [α]: -193 ° (C=0.5, MeOH)
• Punto de fusión (°C): 151°C

Referencias

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