Daidzein - Moligand™, 10mM in DMSO , CAS No.486-66-8

CAS: 486-66-8 Cat. No.: D408512 Peso molecular: 254.24 Beilstein Registry Number: 231523 Número EC: 207-635-4
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Price
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1ml
D408512-1ml
2
41,90US$
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 48 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Information

Daidzein Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements. Daidzein is a soy isoflavone, which acts as a PPAR activator.
In vitro

Daidzein inhibits iNOS protein and mRNA expression and also NO production in a dose-dependent manner. Daidzein also inhibits the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS. Daidzein (1 μM and 10 μM) causes a significant elevation of protein content, alkaline phosphatase activity, and DNA content in cells; those increases are about 1.4-, 1.5-, and 2.0-fold, respectively. Daidzein (2-50 mM) increases the viability of osteoblasts by about 1.4-fold. Daidzein (2-100 mM) increases the alkaline phosphatase activity and osteocalcin synthesis of osteoblasts by about 1.4- and 2.0-fold, respectively. Daidzein stimulates osteoblast differentiation at various stages (from osteoprogenitors to terminally differentiated osteoblasts). Daidzein (1 μM and 10 μM) causes a significant increase of alkaline phosphatase activity, deoxyribonucleic acid (DNA) and calcium contents in bone tissues. Daidzein-induced increase of calcium content and alkaline phosphatase activity in bone tissues is completely prevented by cycloheximide (1 μM).

In vivo

Daidzein results in reduced body weight, a fact that may be explained by reduced feed consumption in female rats. Daidzein results in slight, but not significant, decreases in ovarian and uterine weights, and mammary gland size in female rats.
Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

Specifications

Sinónimos
7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
Especificaciones y pureza
Moligand™, 10mM in DMSO
Mecanismos bioquímicos y fisiológicos
Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements. Daidzein is a soy isoflavone, which acts as a PPAR activator.
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Nombres e identificadores
Isómeros SMILES C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O
WGK Alemania 3
RTECS DJ3100040
Peso molecular 254.24
Beilstein 231523
Reaxy-Rn 231523
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=231523&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Objetivos asociados (humanos)
CA4 Tclin Carbonic anhydrase 4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA12 Tclin Carbonic anhydrase 12 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA7 Tclin Carbonic anhydrase 7 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu.  (2023)  Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes.  JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,      [PMID:38143010] [10.1016/j.jsbmb.2023.106450]
2. Wei Zhang, Hui Li, Weihong Cao, Zhenghong Guo, Zhengping Fang, Juan Li, Peng Chen.  (2023)  A key role of a bio-based charring-coupling agent in flame retardant and anti-dripping performance of polyamide 6/aluminum diethylphosphinate.  JOURNAL OF APPLIED POLYMER SCIENCE,  140  (34): (e54327).  [PMID:] [10.1002/app.54327]
3. Qin Yuan, Meng Fuliang, Xu Chunyu, Hu Zhenguo, Zhang Yimiao, Jia Yufei, Li Songjun, Yuan Xinhua.  (2023)  Preparation and Performance of Novel Flavonoid Phenols-Based Biomass-Modified Phenol Formaldehyde Resins.  Journal of Inorganic and Organometallic Polymers and Materials,  33  (7): (1817-1829).  [PMID:] [10.1007/s10904-023-02619-7]
4. Ruiyi Fan, Congyi Zhu, Diyang Qiu, Genlin Mao, Bernd Mueller-Roeber, Jiwu Zeng.  (2023)  Integrated transcriptomic and metabolomic analyses reveal key genes controlling flavonoid biosynthesis in Citrus grandis ‘Tomentosa’ fruits.  PLANT PHYSIOLOGY AND BIOCHEMISTRY,      [PMID:36724705] [10.1016/j.plaphy.2023.01.050]
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10. Lei Du, Kum-Song Ro, Yiji Zhang, Ya-Jie Tang, Wanbang Li, Jingli Xie, Dongzhi Wei.  (2021)  Effects of lactiplantibacillus plantarum X7021 on physicochemical properties, purines, isoflavones and volatile compounds of fermented soymilk.  PROCESS BIOCHEMISTRY,      [PMID:] [10.1016/j.procbio.2021.12.028]
11. Yonggang Du, Ge Zhao, Gonghui Shi, Yiming Wang, Wei Li, Shitong Ren.  (2021)  Effect of crosslink structure on mechanical properties, thermal stability and flame retardancy of natural flavonoid based epoxy resins.  EUROPEAN POLYMER JOURNAL,      [PMID:] [10.1016/j.eurpolymj.2021.110898]
12. Zhou Lu, Yat-Tin Chan, Kenneth Ka-Hei Lo, Vincy Wing-Si Wong, Yuk-Fan Ng, Shi-Ying Li, Wing-Wa Ho, Man-Sau Wong, Danyue Zhao.  (2021)  Levels of polyphenols and phenolic metabolites in breast milk and their association with plant-based food intake in Hong Kong lactating women.  Food & Function,  12  (24): (12683-12695).  [PMID:34825914] [10.1039/D1FO02529E]
13. Yufan Zhu, Zhiqiang Yang, Yuanlong Xie, Min Yang, Yufeng Zhang, Zhouming Deng, Lin Cai.  (2021)  Investigation of inhibition effect of daidzein on osteosarcoma cells based on experimental validation and systematic pharmacology analysis.  PeerJ,      [PMID:34540371] [10.7717/peerj.12072]
14. Liuying Zhu, Wenting Li, Zeyuan Deng, Hongyan Li, Bing Zhang.  (2020)  The Composition and Antioxidant Activity of Bound Phenolics in Three Legumes, and Their Metabolism and Bioaccessibility of Gastrointestinal Tract.  Foods,  (12): (1816).  [PMID:33297502] [10.3390/foods9121816]
15. Yu-ting Li, Ming-shun Chen, Li-zhen Deng, Ya-zhen Liang, Yi-kun Liu, Wei Liu, Jun Chen, Cheng-mei Liu.  (2020)  Whole soybean milk produced by a novel industry-scale micofluidizer system without soaking and filtering.  JOURNAL OF FOOD ENGINEERING,      [PMID:] [10.1016/j.jfoodeng.2020.110228]
16. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song.  (2020)  Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:32480277] [10.1016/j.saa.2020.118519]
17. Lizhen Liu, Zhi Mi, Ziying Guo, Junling Wang, Feng Feng.  (2020)  A label-free fluorescent sensor based on carbon quantum dots with enhanced sensitive for the determination of myricetin in real samples.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2020.104956]
18. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang.  (2020)  Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations.  FOOD CHEMISTRY,      [PMID:32330646] [10.1016/j.foodchem.2020.126807]
19. Yujuan Zhang, Jinhu Huang, Xiangxiu Li, Ci Fang, Liping Wang.  (2020)  Identification of Functional Transcriptional Binding Sites within Chicken Abcg2 Gene Promoter and Screening Its Regulators.  Genes,  11  (2): (186).  [PMID:32050731] [10.3390/genes11020186]
20. Xianli Gao, Ermeng Liu, Junke Zhang, Mingquan Yang, Sui Chen, Zhan Liu, Haile Ma, Feng Hu.  (2019)  Effects of sonication during moromi fermentation on antioxidant activities of compounds in raw soy sauce.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2019.108605]
21. Xiaonan Zhang, Hongwei Zhang, Xinghao Xia, Nan Pu, Zhuping Yu, Mourtada Nabih, Ying Zhu, Shuang Zhang, Lianzhou Jiang.  (2019)  Preparation and physicochemical characterization of soy isoflavone (SIF) nanoparticles by a liquid antisolvent precipitation method.  ADVANCED POWDER TECHNOLOGY,      [PMID:] [10.1016/j.apt.2019.04.030]
22. Xingyu Hou, Wei Huang, Fugui Zhu, Fang Geng, Miaomiao Tian.  (2018)  A new boronate-affinity hollow solid phase extraction adsorbent for the enrichment of cis-diol-containing isoflavones in soybean milk samples.  Analytical Methods,  11  (3): (317-326).  [PMID:] [10.1039/C8AY02311E]
23. Binle Zhang, Zixuan Yang, Weining Huang, Jacob Ojobi Omedi, Feng Wang, Qibo Zou, Jianxin Zheng.  (2018)  Isoflavone aglycones enrichment in soybean sourdough bread fermented by lactic acid bacteria strains isolated from traditional Qu starters: Effects on in vitro gastrointestinal digestion, nutritional, and baking properties.  CEREAL CHEMISTRY,  96  (1): (129-141).  [PMID:] [10.1002/cche.10116]
24. Hui Wang, Wenxi Zhang, Yatao Cheng, Xinyu Zhang, Nannan Xue, Gaorong Wu, Meng Chen, Kang Fang, Wenbo Guo, Fei Zhou, Herong Cui, Tao Ma, Penglong Wang, Haimin Lei.  (2018)  Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents.  MOLECULES,  23  (9): (2187).  [PMID:30200208] [10.3390/molecules23092187]
25. Jinyue Dai, Yunyan Peng, Na Teng, Yuan Liu, Chuanchuan Liu, Xiaobin Shen, Sakil Mahmud, Jin Zhu, Xiaoqing Liu.  (2018)  High-Performing and Fire-Resistant Biobased Epoxy Resin from Renewable Sources.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.8b00439]
26. Hu Yue, Xia Qinfei, Huang Wei, Hou Xingyu, Tian Miaomiao.  (2017)  Boronate-modified hollow molecularly imprinted polymers for selective enrichment of glycosides.  MICROCHIMICA ACTA,  185  (1): (1-9).  [PMID:29594569] [10.1007/s00604-017-2608-2]
27. Shujing Li, Li Yuan, Yong Chen, Wei Zhou, Xinrui Wang.  (2017)  Studies on the Inclusion Complexes of Daidzein with β-Cyclodextrin and Derivatives.  MOLECULES,  22  (12): (2183).  [PMID:29292784] [10.3390/molecules22122183]
28. Zhongxiang Xiao, Chang Le, Zhenghao Xu, Zhefeng Gu, Junfei Lv, Imran Haider Shamsi.  (2017)  Vertical Leaching of Allelochemicals Affecting Their Bioactivity and the Microbial Community of Soil.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:28800227] [10.1021/acs.jafc.7b01581]
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30. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang.  (2017)  Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr).  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2017.03.003]
31. Yamin Fu, Lu Wang, Yinghao Duan, Lina Zou, Baoxian Ye.  (2017)  Facile synthesized SnO2 decorated functionalized graphene modified electrode for sensitive determination of daidzein.  TALANTA,      [PMID:28391825] [10.1016/j.talanta.2017.03.006]
32. Yinghui Deng, Yanhua Pang, Yafei Guo, Yufeng Ren, Fen Wang, Xiali Liao, Bo Yang.  (2016)  Host-guest inclusion systems of daidzein with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulfobutyl ether-β-cyclodextrin (SBE-β-CD): Preparation, binding behaviors and water solubility.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2016.04.040]
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