Flavonoid natural products are not merely general free-radical-scavenging constituents, but important regulatory molecules capable of acting simultaneously on reactive oxygen species generation, redox buffering, inflammatory sensing, signal transduction, and inflammatory execution.
Sphingolipid metabolism is not merely a process of membrane-lipid turnover, but an important signaling layer linking death-receptor activation, mitochondrial injury, inflammasome assembly, and cell-fate determination.
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