DBCO-NHS ester - ≥97% , CAS No.1353016-71-3

CAS: 1353016-71-3 Cat. No.: D595518 Peso molecular: 402.40 Número EC: 978-533-1

GRADE & PURITY ≥97%

Synonyms

DBCO-NHS | N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate | (2,5-dioxopyrrolidin-1-yl) 4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoate | Dibenzocyclooctyne-N-hydroxysuccinimidyl ester

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

DBCO-NHS Ester is an amine-reactive compound and can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Specifications

Sinónimos

DBCO-NHS | N-Succinimidyl 4-[(5-Aza-3, 4:7, 8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate | (2, 5-dioxopyrrolidin-1-yl) 4-(2-azatricyclo[10.4.0.04, 9]hexadeca-1(16), 4, 6, 8, 12, 14-hexaen-10-yn-2-yl)-4-oxobutanoate | Dibenzocyclooctyne-N-hydroxysuccinimidyl ester

Especificaciones y pureza

≥97%

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥97%

Nombres e identificadores

• Sonrisas canónicas: C1CC(=O)N(C1=O)OC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoate
• InChIKey: XCEBOJWFQSQZKR-UHFFFAOYSA-N
• INCHI: 1S/C23H18N2O5/c26-20(13-14-23(29)30-25-21(27)11-12-22(25)28)24-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)24/h1-8H,11-15H2
• Isómeros SMILES: C1CC(=O)N(C1=O)OC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42
• Peso molecular: 402.40

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Not available
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzenoids
• Alternative Parents: Pyrrolidine-2-ones Tertiary carboxylic acid amides Dicarboximides Lactams Monocarboxylic acids and derivatives Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Pyrrolidone - 2-pyrrolidone - Benzenoid - Dicarboximide - Pyrrolidine - Tertiary carboxylic acid amide - Carboxamide group - Lactam - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Azacycle - Organoheterocyclic compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as benzenoids. These are aromatic compounds containing one or more benzene rings.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Solubility in DMSO, DCM, DMF
• Sensibilidad: Light，Moisture and Heat sensitive
• Peso molecular: 402.400 g/mol
• XLogP3: 1.700
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 402.122 Da
• Monoisotopic Mass: 402.122 Da
• Topological Polar Surface Area: 84.000 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 778.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Manting Li, Haikun Luo, Zhao Wang, Qian Mo, Shanshan Zhong, Yu-ang Mao, Shuting Li, Xinchun Li.  (2024)  Tuning quantum dots emission on DNA tetrahedron/silica nanosphere/graphene oxide nanointerface for ratiometric fluorescence assay of Pb2+ in multiplex samples.  ANALYTICA CHIMICA ACTA,      [PMID:38811135] [10.1016/j.aca.2024.342716]

2. Liuxian Chen, Qin Huang, Yongjie Liu, Ke Chen, Qing Yang, Hua Tang, Dan Wang, Zhenrong Tang.  (2025)  A Galactose-Engineered Dual-Responsive Nanocarrier for ASO/CRISPR-Cas9 Delivery to Inhibit HBV Replication.  Advanced Healthcare Materials,      [PMID:41039747] [10.1002/adhm.202502835]

3. Siqiang Wang, Kai Li, Zitang Xu, Hao Wang, Qiyang Wang, Ao Lin, Pengbo Wang, Xiaoman Xie, Li Xu, Yunjun Yan.  (2026)  Mussel-inspired bioadhesive via enzymatic adhesive peptide synthesis and liquid-liquid phase separation for robust adhesion in harsh environments.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2026.173645]

4. Cong He, Hairong Yu, Jiaqi Tian, Ziling Huang, Xue Yang, Jingru Zhang, Wenjing Chen, Yayue Zhang, Xuran Ding, Yabing Hua, Yuan He, Yan Liu, Ziming Zhao, Yihua Yang.  (2026)  Transferrin-modified bone marrow mesenchymal stem cell co-loaded with phthalocyanine and perfluorohexane for targeted antitumor therapy.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:41702148] [10.1016/j.colsurfb.2026.115544]