Dutasteride - Moligand™, 10mM in DMSO , Steroid 5-alpha-reductase inhibitor, CAS No.164656-23-9, Steroid 5-alpha-reductase inhibitor

CAS: 164656-23-9 Cat. No.: D407951 Peso molecular: 528.53 Número EC: 638-758-5

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

GI198745, GG-745 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Dutasteride Dutasteride (GI198745, GG-745) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).
In vitro

Dutasteride inhibits type-1 5AR and type-2 5AR with IC50 of 6 nM and 7 nM, respectively. Dutasteride is 60-fold more potent than Finasteride in its initial Ki versus type 1 5AR and ~5-fold more rapid in inactivating the enzyme. Dutasteride inhibits (3)H-T conversion to (3)H-DHT and, as anticipated, inhibits T-induced secretion of PSA and proliferation in LNCaP cells. Dutasteride also inhibits DHT-induced PSA secretion and cell proliferation with IC50 of 1 μM in LNCaP cells. Dutasteride competes for binding the LNCaP cell AR with an IC50 of 1.5 μM. Dutasteride (10–50 μM) results in enhanced cell death, possibly by apoptosis, in steroid-free medium. Dutasteride reduces cell viability and cell proliferation in androgen-responsive (LNCaP) and androgen-unresponsive (DU145) human prostate cancer(PCa) cell lines. Dutasteride results in overexpressed genes included genes encoding for proteins involved in biosynthesis and metabolism of androgen (HSD17B1;HSD17B3;CYP11B2), androgen receptor and androgen receptor co-regulators (AR;CCND1), and signal transduction(ERBB2; V-CAM; SOS1) whereas, underexpressed genes (KLK3; KLK2; DHCR24) are androgen-regulated genes (ARGs) in androgen-responsive (LNCaP) cell. Dutasteride inhibits FASN mRNA, protein expression and enzymatic activity in prostate cancer cells.

In vivo

Dutasteride (100 mg/kg/day) has prostates about half as large as those in intact male rats treated with vehicle alone. Dutasteride is orally bioavailable and because of its mechanism of action it easily overcomes the potential liability of being >99% plasma protein bound.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

GI198745, GG-745 | (4aR, 4bS, 6aS, 7S, 9aS, 9bS, 11aR)-N-(2, 5-bis(trifluoromethyl)phenyl)-4a, 6a-dimethyl-2-oxo-2, 4a, 4b, 5, 6, 6a, 7, 8, 9, 9a, 9b, 10, 11, 11a-tetradecahydro-1H-indeno[5, 4-f]quinoline-7-carboxamide

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Dutasteride (GI198745, GG-745) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Steroid 5-alpha-reductase inhibitor

Propiedades del producto

• ALogP: 5.4

Nombres e identificadores

• Isómeros SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CC[C@@H]5[C@@]3(C=CC(=O)N5)C
• Peso molecular: 528.53
• Reaxy-Rn: 24888215
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24888215&ln=

Objetivos asociados (humanos)

SRD5A1 Tclin 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (1 Activities)

Discover Target: SRD5A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLRA1 Tclin Glycine receptor subunit alpha-1 (1 Activities)

Discover Target: GLRA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de fusión (°C): 246.0 to 250.0 °C

Referencias

1. Xin Meng, Ye Wang.  (2021)  Drug Repurposing for Influenza Virus Polymerase Acidic (PA) Endonuclease Inhibitor.  MOLECULES,  26  (23): (7326).  [PMID:34885905] [10.3390/molecules26237326]

2. Runlan Wan, Xi Kong, Youzhe Yang, Siwen Tao, Youyou Chen, Alexander Tobias Teichmann, Frank Heinrich Wieland.  (2019)  Role of human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C3) in the extrahepatic metabolism of the steroidal aromatase inactivator Formestane.  JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,      [PMID:31733346] [10.1016/j.jsbmb.2019.105527]

3. Yudie Lv, Yongjia Zhang, Xiaoli Zhou, Weili Yang, Ting Zhang, Han Zhang, Yao Li, Ruibo Zhao, Xiangdong Kong.  (2025)  Bifunctional sodium hyaluronate microneedle patches integrating 5α-reductase and ROS regulation for boosted hair regeneration.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40716533] [10.1016/j.ijbiomac.2025.146316]