1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
Genipin is a naturally occurring iridoid compound obtained primarily from the fruit of Gardenia jasminoides Ellis, which belongs to the genus Gardenia in the Rubiaceae family. In the plant, genipin exists mainly in the form of geniposide, a glycoside. When geniposide is hydrolyzed (via enzymatic ...
Leucine-rich repeat kinase 2 (LRRK2) is a protein localized in both the cytoplasm and the outer membrane of mitochondria. Gain-of-function mutations in LRRK2 have been linked to an elevated risk of Crohn’s disease as well as Parkinson’s disease. Parkinson’s disease models indicate that ...
Research over the past several years has suggested a potential connection between Alzheimer’s disease (AD) and insulin resistance. Similarities between AD and type 2 diabetes mellitus (T2DM) are evident in disruptions to insulin signaling, which influence cell growth, differentiation, repair ...
Neuropeptides are active signaling molecules synthesized by neurons. Their communication typically occurs locally—one neuron releases a neuropeptide, which then binds to a G-protein–coupled receptor located on a nearby neuron’s surface. While often co-released alongside a primary ...
Paroxetine Hydrochloride is an antidepressant widely prescribed for conditions such as major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, and both generalized and social anxiety disorders. Classified as a selective serotonin reuptake inhibitor (SSRI), ...
Zonisamide is an anticonvulsant medication used to manage partial-onset seizures, generalized tonic–clonic seizures, myoclonic seizures, and mixed seizure types in Lennox–Gastaut syndrome. Its mechanisms of action include inhibition of voltage-gated sodium channels, blockade of T-type ...
Transient receptor potential (TRP) channels are ion channels embedded in the plasma membrane of many cell types, where they play key roles in sensory transduction, including the detection of pain, temperature, taste, and mechanical pressure.
γ-Secretase is a multi-subunit enzyme complex that catalyzes the cleavage of various transmembrane proteins, including amyloid precursor protein (APP) and Notch. Processing of APP by γ-secretase leads to the production of amyloid-β peptides, which aggregate to form the amyloid plaques that ...
Alzheimer’s disease is the most common neurodegenerative disorder and a leading cause of dementia in aging populations. The condition triggers a cascade of pathological processes that result in signaling pathway disruption, impaired neurotransmission, and eventual neuronal loss. Memantine is ...