Prostaglandin E2 (PGE2) - Moligand™, 10mM in DMSO , Activator of CatSper1;Activator of CatSper2;Activator of CatSper3;Activator of CatSper4;Agonist of DP 1 receptor;Agonist of DP 2 receptor;Agonist of EP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3, Activator of CatSper1;Activator of CatSper2;Activator of CatSper3;Activator of CatSper4;Agonist of DP 1 receptor;Agonist of DP 2 receptor;Agonist of EP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor;Agonist of FP rec

CAS: 363-24-6 Cat. No.: P408151 Fórmula: C20H32O5 Peso molecular: 352.47 Número EC: 206-656-6
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
Dinoprostone
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
Size
USA
Alemania (EU)*
Price
Qty
1ml
P408151-1ml
1 Disponible

169,90US$

198,90US$
Guardar 29,00 US$ (14.58%)
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 7 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Information

Prostaglandin E2 (PGE2) Prostaglandin E2 (PGE2, Dinoprostone) palys important effects in labour (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts.
In vitro


In vivo


Cell Data

cell lines:LoVo and HT-29 cells

Concentrations:

Incubation Time:

Powder Purity:

Specifications

Sinónimos
Dinoprostone
Especificaciones y pureza
Moligand™, 10mM in DMSO
Mecanismos bioquímicos y fisiológicos
'}
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
ACTIVATOR, AGONIST
Mecanismo de acción
Activator of CatSper1;Activator of CatSper2;Activator of CatSper3;Activator of CatSper4;Agonist of DP 1 receptor;Agonist of DP 2 receptor;Agonist of EP 1 receptor;Agonist of EP 2 receptor;Agonist of EP 3 receptor;Agonist of EP 4 receptor;Agonist of FP rec
Propiedades del producto
ALogP2.8
Nombres e identificadores
Isómeros SMILES CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)O
RTECS UK8000000
Peso molecular 352.47
Reaxy-Rn 2705862
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2705862&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Objetivos asociados (humanos)
CATSPER4 Tchem Cation channel sperm-associated protein 4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CATSPER1 Tchem Cation channel sperm-associated protein 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CATSPER3 Tchem Cation channel sperm-associated protein 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CATSPER2 Tchem Cation channel sperm-associated protein 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGER2 Tclin Prostaglandin E2 receptor EP2 subtype (16 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGER4 Tclin Prostaglandin E2 receptor EP4 subtype (23 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGDR2 Tchem Prostaglandin D2 receptor 2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGER1 Tclin Prostaglandin E2 receptor EP1 subtype (7 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGFR Tclin Prostaglandin F2-alpha receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PTGER3 Tclin Prostaglandin E2 receptor EP3 subtype (13 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TBXA2R Tclin Thromboxane A2 receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
Punto de fusión (°C)66°C(lit.)
Preguntas frecuentes y artículos
Molecular Network of the Kinin System in Pain and Neural Regulation
GPCR/G Protein Signal Transduction Mechanisms and Disease Research
Inflammatory Signaling Pathway Research Guide: Danger Signal Recognition, Core Signaling Modules, Detection Readouts, and Representative Research Reagents
Scientific Rationale and Application Assessment of Olive Leaf Extract in Skin Redness Care
Mechanism of Action of Tranexamic Acid in Pigmentation Care: From the Plasmin System to Regulation of Inflammation-Driven Pro-Melanogenic Signaling
Are Lipids Fats? Understanding the Multiple Functions of Lipids from Cellular Metabolism to mRNA Delivery
Citations of This Product
Referencias
1. Qi-Rui Hu, Qing-Xin Huang, Huan Hong, Yao Pan, Ting Luo, Jing Li, Ze-Yuan Deng, Fang Chen.  (2023)  Ginsenoside Rh2 and its octyl ester derivative inhibited invasion and metastasis of hepatocellular carcinoma via the c-Jun/COX2/PGE2 pathway.  PHYTOMEDICINE,      [PMID:37806155] [10.1016/j.phymed.2023.155131]
2. Mingrui Xiong, Hong Chen, Yu Fan, Muchuan Jin, Dong Yang, Yuchen Chen, Yu Zhang, Robert B. Petersen, Hua Su, Anlin Peng, Congyi Wang, Ling Zheng, Kun Huang.  (2023)  Tubular Elabela-APJ axis attenuates ischemia-reperfusion induced acute kidney injury and the following AKI-CKD transition by protecting renal microcirculation.  Theranostics,      [PMID:37351176] [10.7150/thno.84308]
3. Yongzhi Cui, Yuanyuan Guo, Li Kong, Jingyu Shi, Ping Liu, Rui Li, Yongtao Geng, Weihang Gao, Zhiping Zhang, Dehao Fu.  (2021)  A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis.  Bioactive Materials,      [PMID:34901540] [10.1016/j.bioactmat.2021.09.015]
4. Jian Xiao, Shuqing Cao, Jiawei Wang, Pengyu Li, Quan Cheng, Xinyi Zhou, Jiacheng Dong, Yuan Li, Xinyu Zhao, Zekuan Xu, Li Yang.  (2024)  Leptin-mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer.  Cancer Communications,      [PMID:38958445] [10.1002/cac2.12583]
5. Guobin Li, Lan Zhang, Kaiting Ning, Baoqiang Yang, Francisca M. Acosta, Peng Shang, Jean X. Jiang, Huiyun Xu.  (2021)  Osteocytic Connexin43 Channels Regulate Bone–Muscle Crosstalk.  Cells,  10  (2): (237).  [PMID:33530465] [10.3390/cells10020237]
6. Lei Yu, Bai Yaowei, Bai Xiatong, Sun Bo, Zhu Licheng, Wu Wenlong, Su Yang, Zhang Hongsen, Wang Yingliang, Zheng Chuansheng.  (2025)  COX-2/PGE2 axis blockade with celecoxib enhances anti-PD-1 efficacy by activating natural killer cells for residual hepatocellular carcinoma after radiofrequency ablation.  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,  44  (1): (321).  [PMID:41408296] [10.1186/s13046-025-03582-6]
7. Yuan Man-man, Zheng Bing-feng, Wang Jing-lin, Xu Shuai-qi, Wang Sheng-lan, Tan Yang, Feng Yong, Dong Xian-chi, Zhu Qi-hua, Yan Jie, Xu Qiang, Wu Xing-xin.  (2026)  Macrophage FOLR2 drives liver fibrosis via intercellular engagement of TGFβRII.  ACTA PHARMACOLOGICA SINICA,      [PMID:42533081] [10.1038/s41401-026-01878-7]
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