10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 15 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Puromycin (CL13900) 2HCl Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.
In vitro
The antibiotic puromycin is produced by the actinoniycete, Streptornyces alboniger, and has been used as a tool for studying protein synthesis in a number of systems. Puromycin can be used for the selection of recombinant cells from noncultured cells.
In vivo
Cell Data
cell lines：HFF, MCF-7, T47D, A-431, HN5, BT474, N87, CaLu-3, HB4a, and HB4a c5.2 cells
Concentrations：
Incubation Time：
Powder Purity:≥98%
| Isómeros SMILES | CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl |
|---|---|
| WGK Alemania | 3 |
| RTECS | AU7355000 |
| CAS alternativo | 53-79-2 |
| Peso molecular | 544.44 |
| Beilstein | 3853613 |
| Reaxy-Rn | 39769009 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=39769009&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubilidad | Solubility (25°C) In vitro DMSO: 144 mg/mL (196.76 mM); Ethanol: 144 mg/mL (196.76 mM); Water: Insoluble; |
|---|---|
| Punto de fusión (°C) | 174°C(lit.) |
| 1. Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. (2023) Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice. LIFE SCIENCES, [PMID:36758669] [10.1016/j.lfs.2023.121491] |
| 2. Song Runjie, Ma Shuoqian, Xu Jiajia, Ren Xin, Guo Peilan, Liu Huijiao, Li Peng, Yin Fan, Liu Mei, Wang Qiang, Yu Lei, Liu Jiali, Duan Binwei, Rahman Nafis A., Wołczyński Sławomir, Li Guangming, Li Xiangdong. (2023) A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR. Molecular Cancer, 22 (1): (1-20). [PMID:36691031] [10.1186/s12943-023-01719-9] |
| 3. Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. (2022) Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice. LIFE SCIENCES, [PMID:35751919] [10.1016/j.lfs.2022.120725] |
| 4. Qiong Yang, Maochen Xing, Ke Wang, Qiang Wei, Jiarui Zhao, Yuan Wang, Kai Ji, Shuliang Song. (2022) Application of Fucoidan in Caco-2 Model Establishment. Pharmaceuticals, 15 (4): (418). [PMID:35455415] [10.3390/ph15040418] |
| 5. Bo Zhang, Ting Jiang, Li Ling, Zhonglian Cao, Jingjing Zhao, Yanyan Tuo, Xiaojian She, Shun Shen, Xinguo Jiang, Yu Hu, Zhiqing Pang. (2016) Enhanced Antitumor Activity of EGFP-EGF1-Conjugated Nanoparticles by a Multitargeting Strategy. ACS Applied Materials & Interfaces, [PMID:26890991] [10.1021/acsami.6b00036] |
| 6. Jia Liu, Liuting Zheng, Xinyue Li, Wei Tang, Manyu Guo, Yuxing Wang, Xiaoqi Tan, Jiajia Chang, Huiyue Zhao, Dongsheng Zhu, Yu-qiang Ma, Da Huo. (2025) Emerging of Ultrafine Membraneless Organelles as the Missing Piece of Nanostress: Mechanism of Biogenesis and Implications at Multilevels. ACS Nano, [PMID:39882824] [10.1021/acsnano.4c15876] |
| 7. Zikang Xing, Xuewen Li, Zhen Ning Tony He, Xin Fang, Heng Liang, Chunxiang Kuang, Aiying Li, Qing Yang. (2024) IDO1 Inhibitor RY103 Suppresses Trp-GCN2-Mediated Angiogenesis and Counters Immunosuppression in Glioblastoma. Pharmaceutics, 16 (7): (870). [PMID:39065567] [10.3390/pharmaceutics16070870] |
| 8. Ping Yang, Zheng-Jian Wang, Hai-Tao Lu, Xu-Meng Feng, Jing-Long Ye, Guangchuan Wang, Cheng-Feng Qin, Qing Ye, Zhong-Yu Liu. (2024) Imaging of viral replication in live cells by using split fluorescent protein-tagged reporter flaviviruses. VIROLOGY, [PMID:39754862] [10.1016/j.virol.2024.110374] |
| 9. Xinrui Meng, Jingjing Liu, Jia Kang, Menghan Wang, Zhanghui Guan, Dong Tian, Xinping Chen. (2024) Lamivudine protects mice from gastric ulcer by activating PGK1 to suppress ferroptosis. BIOCHEMICAL PHARMACOLOGY, [PMID:39029631] [10.1016/j.bcp.2024.116440] |
| 10. Hui-Yue Zhao, Yuan-Qiang Chen, Xing-Yu Luo, Ming-Jie Cai, Jia-Yi Li, Xin-Yu Lin, Hao Zhang, Hong-Ming Ding, Guang-Liang Jiang, Yong Hu. (2024) Ligand Phase Separation-Promoted, “Squeezing-Out” Mode Explaining the Mechanism and Implications of Neutral Nanoparticles That Escaped from Lysosomes. ACS Nano, [PMID:38198577] [10.1021/acsnano.3c09452] |
| 11. Jingxin Sun, Zhehao Jin, Yong Jin, Haidan Yuan, Guangyu Jin, Jishan Quan. (2025) MRI-Based Multifunctional Nanoliposomes for Enhanced HCC Therapy and Diagnosis. MOLECULAR PHARMACEUTICS, [PMID:39809473] [10.1021/acs.molpharmaceut.4c00917] |
| 12. Wei Li, Qingwen Zeng, Bing Wang, Chao Lv, Haoan He, Xi Yang, Bin Cheng, Xiaoan Tao. (2024) Oxidative stress promotes oral carcinogenesis via Thbs1-mediated M1-like tumor-associated macrophages polarization. Redox Biology, [PMID:39255693] [10.1016/j.redox.2024.103335] |
| 13. Yao Yongchang, Chen Ke, Pan Qian, Gao Hui, Su Weixian, Zheng Shicong, Dong Weiqiang, Qian Dongyang. (2024) Redifferentiation of genetically modified dedifferentiated chondrocytes in a microcavitary hydrogel. BIOTECHNOLOGY LETTERS, [PMID:38523201] [10.1007/s10529-024-03475-2] |
| 14. Xiuli Zhang, Mingjing Wei, Zhigang Zhang, Yarong Zeng, Feihong Zou, Sibo Zhang, Zhiping Wang, Fentian Chen, Hualong Xiong, Yufang Li, Lizhi Zhou, Tingting Li, Qingbing Zheng, Hai Yu, Jun Zhang, Ying Gu, Qinjian Zhao, Shaowei Li, Ningshao Xia. (2024) Risedronate-functionalized manganese-hydroxyapatite amorphous particles: A potent adjuvant for subunit vaccines and cancer immunotherapy. JOURNAL OF CONTROLLED RELEASE, [PMID:38244843] [10.1016/j.jconrel.2024.01.033] |
| 15. Zheng Liu-Ting, Yan Zeng-Shuai, Li Xin-Yue, Chang Jia-Jia, Tan Xiao-Qi, Wang Yu-Xing, Ding Hong-Ming, Liu Qin, Ma Yu-Qiang, Huo Da. (2025) Nanomaterial signatures program biomolecular condensates via triphasic separation for chemoplasticity remodeling. Nature Communications, 16 (1): (1-24). [PMID:41162367] [10.1038/s41467-025-64623-4] |
