Ruthenium Red - ≥95% , CAS No.11103-72-3

CAS: 11103-72-3 Cat. No.: R100832 Peso molecular: 786.35 Número EC: 802-133-7 PubChem CID: 16218584

GRADE & PURITY ≥95%

Synonyms

Ammoniated ruthenium oxychloride | Ruthenium oxychloride ammoniated | Tetraamminechlorohydroxoruthenium(III) chloride | Ruthenium(III) chloride oxide Ammoniated

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

Ruthenium red hinders cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to impede neurotransmitter release.In addition , Ruthenium red blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Ruthenium red is an inhibitor of CaM and Troponin C.Ruthenium red is an inhibitor of Calcium Channel Protein, SERCA and TRPV.
A voltage-sensitive calcium channel inhibitor

Specifications

Sinónimos

Ammoniated ruthenium oxychloride | Ruthenium oxychloride ammoniated | Tetraamminechlorohydroxoruthenium(III) chloride | Ruthenium(III) chloride oxide Ammoniated

Especificaciones y pureza

≥95%

Mecanismos bioquímicos y fisiológicos

Ca 2+ signaling inhibitor. Inhibits mitochondrial Ca 2+ uniporter, Ca 2+ -ATPase, troponin C and calmodulin. Blocks intracellular Ca 2+ release by ryanodine receptor from internal stores. Attenuates capsaicin-induced cation channel opening.

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥95%

Nombres e identificadores

• Pubchem Sid: 504768353
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504768353
• Isómeros SMILES: N.N.N.N.N.N.N.N.N.N.N.N.N.N.O.O.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+2].[Ru+2].[Ru+2]
• WGK Alemania: 3
• PubChem CID: 16218584
• Peso molecular: 786.35

Propiedades químicas y físicas

• Solubilidad: Soluble in NH4OH, and water (10 mg/ml).
• Punto de fusión (°C): >500°C
• Peso molecular: 790.400 g/mol
• Hydrogen Bond Donor Count: 16
• Hydrogen Bond Acceptor Count: 22
• Rotatable Bond Count: 0
• Exact Mass: 792.918 Da
• Monoisotopic Mass: 789.919 Da
• Topological Polar Surface Area: 16.000 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 4.900
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 25

XLogP3

Referencias

1. Yonghong Miao, Xiaoxue Sun, Guojun Gao, Xianglei Jia, Hao Wu, Ying Chen, Liyong Huang.  (2019)  Evaluation of (-)-epigallocatechin-3-gallate (EGCG)-induced cytotoxicity on astrocytes: A potential mechanism of calcium overloading-induced mitochondrial dysfunction.  TOXICOLOGY IN VITRO,      [PMID:31356857] [10.1016/j.tiv.2019.104592]

2. Feng Hong, Wen-Ting Fan, Wei-Hua Huang, Yan-Ling Liu.  (2026)  A Balloon Electrochemical Sensor for Conformal Interfacing With Intestinal Wall and Real-Time Monitoring of Serotonin Release.  Small,      [PMID:41563114] [10.1002/smll.202506988]