10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 8 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Tangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.
In vitro
Tangeretin is a polymethoxylated flavonoid concentrated in the peel of citrus fruits. Recent studies have shown that tangeretin exhibits anti-proliferative, anti-invasive, anti-metastatic, and antioxidant activities. Tangeretin at 2.7 μM induces apoptosis in human promyelocytic leukaemia HL-60 cells, whereas the flavone showed no cytotoxicity against human peripheral blood mononuclear cells (PBMCs). Further study shows that tangeretin at 50 μM exerts its growth-inhibitory effects through modulation of the activities of several key G1 regulatory proteins such as Cdk2 and Cdk4, and mediates the increase of Cdk inhibitors p21 and p27. Pretreatment with tangeretin inhibites IL-1beta-induced p38 MAPK, JNK, and AKT phosphorylation and the downstream activation of NF-kappaB in human lung epithelial carcinoma cells (A549) and and human non-small cell lung carcinoma cells (H1299).
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥97%
| Isómeros SMILES | COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC |
|---|---|
| WGK Alemania | 3 |
| RTECS | DJ3102725 |
| PubChem CID | 68077 |
| Peso molecular | 372.37 |
| Beilstein | 351695 |
| Reaxy-Rn | 351695 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Punto de fusión (°C) | 153.0-157.0°C |
|---|
| 1. Tingyan Liu, Caiyan Zhang, Jiayun Ying, Yaodong Wang, Gangfeng Yan, Yufeng Zhou, Guoping Lu. (2023) Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis. Frontiers in Immunology, [PMID:37205094] [10.3389/fimmu.2023.1134556] |
| 2. Yajing Fang, Fuqiang Liang, Mengmeng Xia, Weiwei Cao, Siyi Pan, Ting Wu, Xiaoyun Xu. (2021) Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells. FOOD AND CHEMICAL TOXICOLOGY, [PMID:34217736] [10.1016/j.fct.2021.112381] |
| 3. Xin Huang, Junxiang Zhu, Li Wang, Huijuan Jing, Chaoyang Ma, Xingran Kou, Hongxin Wang. (2020) Inhibitory mechanisms and interaction of tangeretin, 5-demethyltangeretin, nobiletin, and 5-demethylnobiletin from citrus peels on pancreatic lipase: Kinetics, spectroscopies, and molecular dynamics simulation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:32795575] [10.1016/j.ijbiomac.2020.07.305] |
| 4. Yao Hu, Yang Qin, Chao Qiu, Xueming Xu, Zhengyu Jin, Jinpeng Wang. (2020) Ultrasound-assisted self-assembly of β-cyclodextrin/debranched starch nanoparticles as promising carriers of tangeretin. FOOD HYDROCOLLOIDS, [PMID:] [10.1016/j.foodhyd.2020.106021] |
| 5. Xin Huang, Xingran Kou, Li Wang, Ruya Ji, Chaoyang Ma, Hongxin Wang. (2019) Effective hydroxylation of tangeretin from Citrus Peel (Chenpi) by edible acids and its improvement in antioxidant and anti-lipase activities. LWT-FOOD SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.lwt.2019.108469] |
| 6. Fuqiang Liang, Yajing Fang, Weiwei Cao, Zhuo Zhang, Siyi Pan, Xiaoyun Xu. (2018) Attenuation of tert-Butyl Hydroperoxide (t-BHP)-Induced Oxidative Damage in HepG2 Cells by Tangeretin: Relevance of the Nrf2–ARE and MAPK Signaling Pathways. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:29871486] [10.1021/acs.jafc.8b01875] |
| 7. Yating Lu, Dong Li, Li Li, Tarun Belwal, Yanqun Xu, Xingyu Lin, Zhenhua Duan, Zisheng Luo. (2020) Effects of elevated CO2 on pigment metabolism of postharvest mandarin fruit for degreening. FOOD CHEMISTRY, [PMID:32126463] [10.1016/j.foodchem.2020.126462] |
| 8. Kai Ni, Bo Che, Rong Gu, Chunhong Wang, Hongyang Xu, Huiduo Li, Shiyan Cen, Mingzhi Luo, Linhong Deng. (2024) BitterDB database analysis plus cell stiffness screening identify flufenamic acid as the most potent TAS2R14-based relaxant of airway smooth muscle cells for therapeutic bronchodilation. Theranostics, [PMID:38389834] [10.7150/thno.92492] |
