Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 20 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol.
An antifungal CYP2C9 inhibitor
| ALogP | 1.5 |
|---|
| Pubchem Sid | 504754634 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504754634 |
| Sonrisas canónicas | CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O |
| IUPAC Name | (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol |
| InChIKey | BCEHBSKCWLPMDN-MGPLVRAMSA-N |
| INCHI | 1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1 |
| Isómeros SMILES | C[C@@H](C1=NC=NC=C1F)[C@](CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O |
| WGK Alemania | 3 |
| RTECS | UV9145000 |
| PubChem CID | 71616 |
| Peso molecular | 349.31 |
| Reaxy-Rn | 7694998 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Clase | Benzene and substituted derivatives |
| Subclass | Phenylpropanes |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylpropanes |
| Alternative Parents | Halopyrimidines Fluorobenzenes Aryl fluorides Triazoles Tertiary alcohols Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organofluorides Hydrocarbon derivatives Aromatic alcohols |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Phenylpropane - Fluorobenzene - Halobenzene - Halopyrimidine - Aryl halide - Pyrimidine - Aryl fluoride - Heteroaromatic compound - 1,2,4-triazole - Tertiary alcohol - Azole - Azacycle - Organoheterocyclic compound - Organic oxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Organooxygen compound - Alcohol - Organic nitrogen compound - Aromatic alcohol - Hydrocarbon derivative - Organopnictogen compound - Aromatic heteromonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as phenylpropanes. These are organic compounds containing a phenylpropane moiety. |
| External Descriptors | tertiary alcohol - triazole antifungal drug - conazole antifungal drug - pyrimidines - difluorobenzene |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | May 08, 2026 | V129745 | |
| Certificate of Analysis | Apr 14, 2026 | V129745 | |
| Certificate of Analysis | Apr 07, 2026 | V129745 | |
| Certificate of Analysis | Jan 30, 2026 | V129745 | |
| Certificate of Analysis | Jul 25, 2025 | V129745 | |
| Certificate of Analysis | Jul 25, 2025 | V129745 | |
| Certificate of Analysis | Jul 25, 2025 | V129745 | |
| Certificate of Analysis | May 12, 2025 | V129745 | |
| Certificate of Analysis | May 12, 2025 | V129745 | |
| Certificate of Analysis | May 12, 2025 | V129745 | |
| Certificate of Analysis | May 12, 2025 | V129745 | |
| Certificate of Analysis | May 12, 2025 | V129745 | |
| Certificate of Analysis | Apr 02, 2024 | V129745 | |
| Certificate of Analysis | Apr 02, 2024 | V129745 | |
| Certificate of Analysis | Apr 02, 2024 | V129745 | |
| Certificate of Analysis | Jul 26, 2023 | V129745 | |
| Certificate of Analysis | Jul 26, 2023 | V129745 | |
| Certificate of Analysis | Jul 26, 2023 | V129745 | |
| Certificate of Analysis | Jul 26, 2023 | V129745 | |
| Certificate of Analysis | Jul 26, 2023 | V129745 | |
| Certificate of Analysis | Jul 26, 2023 | V129745 | |
| Certificate of Analysis | Jul 26, 2023 | V129745 | |
| Certificate of Analysis | Jul 26, 2023 | V129745 | |
| Certificate of Analysis | Jul 26, 2023 | V129745 | |
| Certificate of Analysis | Jul 26, 2023 | V129745 | |
| Certificate of Analysis | Jul 26, 2023 | V129745 | |
| Certificate of Analysis | Jul 20, 2023 | V129745 | |
| Certificate of Analysis | Jan 17, 2023 | V129745 | |
| Certificate of Analysis | Jan 17, 2023 | V129745 | |
| Certificate of Analysis | Jan 17, 2023 | V129745 | |
| Certificate of Analysis | Mar 17, 2022 | V129745 | |
| Certificate of Analysis | Mar 17, 2022 | V129745 | |
| Certificate of Analysis | Mar 17, 2022 | V129745 | |
| Certificate of Analysis | Mar 17, 2022 | V129745 |
| Solubilidad | DMSO: 2 mg/mL, clear |
|---|---|
| Rotación específica [α] | -58.0 to -62.0 deg(C=1, MeOH) |
| Punto de ebullición (°C) | ~508.6° C at 760 mmHg |
| Punto de fusión (°C) | 128-134°C |
| Peso molecular | 349.310 g/mol |
| XLogP3 | 1.500 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 5 |
| Exact Mass | 349.115 Da |
| Monoisotopic Mass | 349.115 Da |
| Topological Polar Surface Area | 76.700 Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 448.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Mengming Xia, Xueyi Song, Zebei Lu, Yu Wang, Quan Zhou, Peiwu Geng, Shuanghu Wang, Yunfang Zhou, Qingjun Wu, Aixia Han. (2023) Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC-MS/MS. Thoracic Cancer, 14 (33): (3331-3341). [PMID:37771131] [10.1111/1759-7714.15125] |
| 2. Fei Gong, Huihui Hu, Ying Ouyang, Zheng-Zheng Liao, Ying Kong, Jin-Fang Hu, Hua He, Ying Zhou. (2023) Physiologically-based pharmacokinetic modeling-guided rational combination of tacrolimus and voriconazole in patients with different CYP3A5 and CYP2C19 alleles. TOXICOLOGY AND APPLIED PHARMACOLOGY, [PMID:36931438] [10.1016/j.taap.2023.116475] |
| 3. Yuhao Fu, Ying Li, Yinling Ma, Xueru He, Xuejiao Xun, Yanjun Cui, Liju Fan, Zhanjun Dong. (2022) Effects of voriconazole and fluconazole on the pharmacokinetics of almonertinib in rats by UPLC–MS/MS. BIOMEDICAL CHROMATOGRAPHY, 37 (1): (e5525). [PMID:36241418] [10.1002/bmc.5525] |
| 4. Guo Penghao, Chen Jianlong, Tan Yiwei, Xia Li, Zhang Weizheng, Li Xiaojie, Jiang Yujie, Li Ruiying, Chen Chunmei, Liao Kang, Peng Yaqin. (2022) Comparison of molecular and MALDI-TOF MS identification and antifungal susceptibility of clinical Fusarium isolates in Southern China. Frontiers in Microbiology, [PMID:36386677] [10.3389/fmicb.2022.992582] |
| 5. Qingwen Xu, Yuxi Liu, Wen Sun, Tiantian Song, Xintong Jiang, Kui Zeng, Su Zeng, Lu Chen, Lushan Yu. (2022) Blockade LAT1 Mediates Methionine Metabolism to Overcome Oxaliplatin Resistance under Hypoxia in Renal Cell Carcinoma. Cancers, 14 (10): (2551). [PMID:35626154] [10.3390/cancers14102551] |
| 6. Xin Yang, Zejun Pei, Renjing Hu, Zhehao Zhang, Zaixiang Lou, Xin Sun. (2021) Study on the Inhibitory Activity and Possible Mechanism of Myriocin on Clinically Relevant Drug-Resistant Candida albicans and Its Biofilms. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 44 (3): (305-315). [PMID:33441497] [10.1248/bpb.b20-00246] |
| 7. Kamran Bashir, Zhimin Luo, Guoning Chen, Hua Shu, Xia Cui, Wen Li, Wang Lu, Qiang Fu. (2019) Development of Surface Molecularly Imprinted Polymers as Dispersive Solid Phase Extraction Coupled with HPLC Method for the Removal and Detection of Griseofulvin in Surface Water. International Journal of Environmental Research and Public Health, 17 (1): (134). [PMID:31878121] [10.3390/ijerph17010134] |
| 8. Tingting Liu, Xiaomin Chen, Guanxuanzi Zhang, Jing Zhao, Qian Lu, Fang Wang, Hongxia Li, Bing Liu, Ping Zhu. (2024) An LCMS/MS method for the simultaneous determination of ten antimicrobials and its application in critically ill patients. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:39357099] [10.1016/j.jpba.2024.116489] |
| 9. Mengmin Liang, Qingwen Hu, Junhao Yu, Heng Zhang, Sijie Liu, Jiangrong Huang, Yi Sun. (2025) Baicalein combined with azoles against fungi in vitro. Frontiers in Microbiology, [PMID:40182279] [10.3389/fmicb.2025.1537229] |
| 10. Heng Zhang, Yizheng Zhou, Hanmo Yang, Xinyi Tao, Yinping Chen, Fuqiang Dong, Yi Sun. (2025) In vitro interactions of berbamine hydrochloride and azoles against Aspergillus fumigatus. Microbiology Spectrum, [PMID:40162754] [10.1128/spectrum.03184-24] |
| 11. Ninghong Li, Lu Liu, Dong Liu, Hengyi Yu, Guangjie Yang, Lihui Qiu, Yufei Chen, Dong Xiang, Xuepeng Gong. (2024) Simultaneous determination of three tyrosine kinase inhibitors and three triazoles in human plasma by LC-MS/MS: applications to therapeutic drug monitoring and drug-drug interaction studies. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, [PMID:39208604] [10.1016/j.jchromb.2024.124276] |
| 12. Zhang Heng, Zhu Zhangling, Peng Mengqi, Liu Sijie, Gong Xiao, Chen Tian, Hu Qingwen, Li Linyun, Dun-zhu Zha-xi, Drol-ga Lha-zom, Sun Yi. (2025) Agricultural SDHIs Induce Azole Resistance in Aspergillus fumigatus via Mitochondrial Sdh1 Suppression. MYCOPATHOLOGIA, 190 (5): (1-16). [PMID:40952433] [10.1007/s11046-025-00992-0] |
| 13. Han Xiang, Zhang Heng, Mao Yuqi, Ling Wenhao, Ge Lu, Tang Menghua, Sun Yi, Wu Zhiqin. (2025) First Isolation of a Multi-azole-Resistant Aspergillus fumigatus cyp51A TR46/Y46F/F70L Mutant in a Patient with Fungal Keratitis. MYCOPATHOLOGIA, 190 (5): (1-13). [PMID:40935904] [10.1007/s11046-025-00993-z] |
| 14. Tian Chen, Shaolan Liu, Fei Yang, Zhangxuan He, Menghua Tang, Lu Ge, Hongyi Zhang, Sijie Liu, Xiaolei Zhu, Mengqi Peng, Heng Zhang, Wenxu Cheng, Yi Sun. (2025) Synergistic inhibition of pathogenic fungi by oleanolic acid combined with azoles. Microbiology Spectrum, 13 (8): [PMID:40621912] [10.1128/spectrum.00854-25] |
| 15. Cong Xie, Tongshu Guan, Jin Huang, Jiayu Chen, Yilei Li, Ping Zheng. (2025) Cyp3a4-Mediated in vitro Metabolism and in vivo Disposition of Lorlatinib in Rats. Drug Design Development and Therapy, [PMID:41169706] [10.2147/DDDT.S565228] |
| 16. Wenge Zhang, Jinyao Chen, Min Fang, Minghui Song, Zongxu Gao, Jingru Hao, Zejun Xu, Xiuyun Li, Shicun Zheng, Wenqiang Chang, Hongxiang Lou. (2026) Discovery and Structural Optimization of Spirodioxynaphthalene-Based Mdr1 Efflux Pump Inhibitor to Combat Azole Resistance in Candida albicans. JOURNAL OF MEDICINAL CHEMISTRY, [PMID:41536117] [10.1021/acs.jmedchem.5c03455] |
| 17. Rongkun Zhu, Mengting Cai, Qiuyu Liao, Xiaobin Meng, Hong Yu, Huanghui Zeng, Zhuomiao Lin, Guicui Zhang. (2026) Selective determination of vancomycin in human serum using graphene quantum dots modified with Dihydroxyl functional groups. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.116790] |
| 18. Ling Wang, Haiping Zhong, Hui Zhang, Rongjie Wei, Maoyu Cai, Liangpin Li, Xueyan Zhou, Xia Hua, Shutao Guo, Xiaoyong Yuan. (2026) Dual Ferroptosis-Inhibitory and Antifungal Therapy for Fungal Keratitis Using a Defect-Adhesive Thermoresponsive Hydrogel. Advanced Healthcare Materials, [PMID:41693073] [10.1002/adhm.202504907] |
| 19. Ya-Hong Wang, Die Zhu, Dan Wang, Ruo-Cheng Sheng, Li-Chao Wang, Chen-Ning Zhang, Muhammad Faizan Latif, Huan Li, Feng-Mao Chen. (2026) The complex subunit VdAP-2α regulates polar growth, ergosterol metabolism, and virulence in Verticillium dahliae. Virulence, [PMID:] [10.1080/21505594.2026.2647468] |
| 20. Dongmei Ma, Yanfang Yao, Chi Yang, Hong Lin, Minghui Sun, Yuanyuan Gao, Wenwen Xin, Dandan Wu, Kangfu Ye, Wenxin Luo, Zhenhong Zhuang, Shihua Wang. (2026) The chromatin remodeling factor Arp9 modulates drug-resistance and plays a key role in aflatoxins biosynthesis under mammalian-physiological-temperature in Aspergillus flavus. PLoS Pathogens, 22 (3): (e1014021). [PMID:] [10.1371/journal.ppat.1014021] |
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