WEE1-IN-3 - ≥98% , CAS No.2272976-28-8

CAS: 2272976-28-8 Cat. No.: W648627 Fórmula: C₂₈H₃₁N₇O₂ Peso molecular: 497.59 PubChem CID: 137471996

CALIDAD & PUREZA ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC 50 of <10 nM. WEE1-IN-3 has anticancer activities

In Vitro

WEE1-IN-3 (example 1) inhibits cancer cell growth with IC 50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively.\nWEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ΌΝΑ repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is overexpressed in various cancer types. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: <10 nM (Wee1 kinase)

Especificaciones

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC 50 of <10 nM. WEE1-IN-3 has anticancer activities.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

Sonrisas canónicas

CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC5=C(C=C4)C6(CC6)CN(C5)C)O

IUPAC Name

1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[(2-methylspiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-7-yl)amino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one

InChIKey

JSZFIXAMFNNRKS-UHFFFAOYSA-N

INCHI

1S/C28H31N7O2/c1-5-13-34-25(36)20-15-29-26(32-24(20)35(34)23-8-6-7-22(31-23)27(2,3)37)30-19-9-10-21-18(14-19)16-33(4)17-28(21)11-12-28/h5-10,14-15,37H,1,11-13,16-17H2,2-4H3,(H,29,30,32)

Isómeros SMILES

CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC5=C(C=C4)C6(CC6)CN(C5)C)O

PubChem CID

137471996

Peso molecular

497.59

Objetivos asociados (humanos)

NCI-H23 (49055 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO : 250 mg/mL (502.42 mM; Need ultrasonic)