Moligand™,10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 11 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
In vitro
Z-VAD-FMK\xa0(10 μM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK\xa0(10 μM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay.
In vivo
In vivo Z-VAD-FMK administration has been shown previously to be nontoxic and to prevent apoptosis in animal models. Intraperitoneal HK-GBS injection leads to preterm delivery, and pretreatment with Z-VAD-FMK delays preterm delivery in mice. In OVA-sensitized mice,treatment of z-VAD-fmk inhibits allergen-induced leukocyte infiltration. Systemic injection of the pan-caspase inhibitor z-VAD-fmk immediately before OVA challenge reduced inflammatory cell accumulation, mucus hypersecretion, and Th2 cytokine release in OVA-sensitized/challenged mice. Treatment with z-VAD-fmk blocked terminal differentiation of lens epithelial cells and keratinocytes, the differentiation of monocytes into macrophages, and the differentiation of erythroid progenitors. z-VAD-fmk attenuated allergen-induced airway inflammation and hyperreactivity. Treatment with z-VAD-fmk in vivo also prevented subsequent T cell activation ex vivo.
Cell Data
cell lines：Pre-B ALL
Concentrations：50 μM
Incubation Time：48 h
Powder Purity:≥99%
| Isómeros SMILES | C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1 |
|---|---|
| PubChem CID | 5497174 |
| Peso molecular | 467.49 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 E2417016 | Certificate of Analysis | Apr 10, 2026 | Z408507 |
| Solubilidad | Solubility (25°C) In vitro Water: 100 mg/mL (95.95 mM); |
|---|
| 1. Bo Xu, Zezhu Zhou, Jiaqi Fang, Jianguang Wang, Kun Tao, Junjian Liu, Shuhao Liu. (2023) Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:37640169] [10.1016/j.freeradbiomed.2023.08.026] |
| 2. Bo Xu, Jiaqi Fang, Jianguang Wang, Xuehan Jin, Shengfu Liu, Kaihang Song, Ping Wang, Junjian Liu, Shuhao Liu. (2023) Inhibition of autophagy and RIP1/RIP3/MLKL-mediated necroptosis by edaravone attenuates blood spinal cord barrier disruption following spinal cord injury. BIOMEDICINE & PHARMACOTHERAPY, [PMID:37459660] [10.1016/j.biopha.2023.115165] |
| 3. Ju Yang, Ping Liu, Dan Ma, Peng Zhao, Yan Zhang, Yinghao Lu, Yanju Li, Yi Huang, Ying Chen, Jishi Wang. (2020) Glucocorticoid resistance induced by ANXA5 overexpression in B-cell acute lymphoblastic leukemia. PEDIATRIC HEMATOLOGY AND ONCOLOGY, [PMID:33231128] [10.1080/08880018.2020.1810182] |
| 4. Wu Chuanhong, Zhao Wenwen, Yu Jie, Li Shaojing, Lin Ligen, Chen Xiuping. (2018) Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells. Scientific Reports, 8 (1): (1-11). [PMID:29330409] [10.1038/s41598-017-18935-1] |
| 5. Fang Liu, Yaru Li, Yao Li, Zheng Wang, Xin Li, Yancheng Liu, Yanjun Zhao. (2024) Triggering multiple modalities of cell death via dual-responsive nanomedicines to address the narrow therapeutic window of β-lapachone. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:39270391] [10.1016/j.jcis.2024.09.063] |
| 6. Chen Yuxing, Tao Yong, Huang Qiu, Xu Jingtao, Wang Zhenxin, Zhang Ye, Fu Guangxu, Tan Fuqiang, Feng Keyi, Ou Yunsheng. (2025) Hino-Fe Chelate Suppresses Osteosarcoma Progression through Dual Induction of Ferroptosis and NLRC4-mediated Pyroptosis: Mechanisms and Therapeutic Implications. International Journal of Biological Sciences, 21 (11): (4872-4894). [PMID:40860199] [10.7150/ijbs.113785] |
| 7. Liyun Zheng, Zhongwei Zhao, Li Chen, Wenjing Yang, Giorgio Ercolani, Pan Qin, Bin Lin, Mengzhu Han, Qiaoyou Weng, Yeyu Zhang, Bin Wu, Minjiang Chen, Zouying Yao, Shiji Fang, Jiansong Ji. (2025) Astragalin Induces Immunogenic Cell Death in Liver Cancer by Targeting NQO2 to Promote ROS-Mediated Endoplasmic Reticulum Stress Pathway. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:40749898] [10.1016/j.freeradbiomed.2025.07.047] |
| 8. Lei Shu, Peili Luo, Chuanyu Ren, Ziwei Lai, Xuejuan Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang. (2025) Inhalable Fibroin Hybrid Liposomes for the Targeted Treatment of Lung Adenocarcinoma via Autophagy-Enhanced Ferroptosis. ACS Nano, [PMID:40878028] [10.1021/acsnano.5c09493] |
| 9. Shichen Zhang, Lei Guo, Yixin Tang, Yixing Wang, Heshi Liu, Chang Liu, Xiuzhang Yan, Congcong Duan, Huanyan Dai, Bing Han, Caina Xu. (2025) Self-reinforced nanoreactor for apoptosis/ferroptosis synergistic therapy of head and neck squamous cell carcinoma. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.166941] |
| 10. Deshan Yao, Liuxiang Bao, Sichuan Wang, Meng Tan, Yuanyuan Xu, Tianxu Wu, Zhengang Zhang, Kaizheng Gong. (2024) Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7A11/GPX4 axis in mice. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:38734270] [10.1016/j.freeradbiomed.2024.05.012] |
| 11. Yu-Zhang Wang, Wei-Hai Chen, Zi-Yi Han, Shi-Man Zhang, Ping Ji, Cheng Zhang, Jun-Long Liang, Xian-Zheng Zhang. (2025) Targeted tumor therapy with L-cyst(e)ine-addicted bacteria-nanodrug biohybrids. Cell Metabolism, [PMID:40215982] [10.1016/j.cmet.2025.03.012] |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Moligand™ grade guide →
