MAP4K

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  1. PF 06260933 dihydrochloride
    CAS: 1883548-86-4 PubChem CID: 118701007 분자식: C16H13ClN4.2HCl 분자량: 369.68
    ◐ .주문제작 · 8~12주 항목 #: P288924
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    IUPAC 이름
    5-(6-aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine;dihydrochloride
    SMILES
    C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl.Cl.Cl
    InChIKey
    VRQXEOPUAQLBQI-UHFFFAOYSA-N
    InChI
    1S/C16H13ClN4.2ClH/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11;;/h1-9H,(H2,18,20)(H2,19,21);2*1H
    Synonyms
    5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride
  2. TL4-12
    CAS: 1620820-12-3 PubChem CID: 134812827 분자식: C25H27F3N6O2 분자량: 500.53
    ● 재고 있음 — 미국 항목 #: T288817
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    IUPAC 이름
    4-methyl-3-[6-(methylamino)pyrimidin-4-yl]oxy-N-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide
    SMILES
    CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3CCN(CC3)C)OC4=NC=NC(=C4)NC
    InChIKey
    HXKJJIMUMNPQQY-UHFFFAOYSA-N
    InChI
    1S/C25H27F3N6O2/c1-16-4-5-17(10-21(16)36-23-14-22(29-2)30-15-31-23)24(35)32-19-11-18(25(26,27)28)12-20(13-19)34-8-6-33(3)7-9-34/h4-5,10-15H,6-9H2,1-3Hshow more
    Synonyms
    4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide
  3. NG25, Inhibitor of C-terminal Src kinase;Inhibitor of LYN proto-oncogene; Src family tyrosine kinase;Inhibitor of mitogen-activated protein kinase kinase kinase 7;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 2;Inhibitor of SRC proto-oncoge
    CAS: 1315355-93-1 EC 번호: 110-114-3 분자식: C29H30F3N5O2 분자량: 537.58
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● 재고 있음 — 미국 항목 #: N125272
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    IUPAC 이름
    N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
    SMILES
    CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=C5C=CNC5=NC=C4)C(F)(F)F
    InChIKey
    SMPGEBOIKULBCT-UHFFFAOYSA-N
    InChI
    1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-1show more
    Synonyms
    AC-35824 | Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]py...
  4. DMX-5084
    CAS: 2306178-56-1 분자식: C21H19N3O3 분자량: 361.39
    10mM in DMSO
    ● 재고 있음 — 미국 항목 #: D422736
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    IUPAC 이름
    5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4-one
    SMILES
    COCCOC1=CC=C(C=C1)C2=CN(C3=C2C(=O)NC=N3)C4=CC=CC=C4
    InChIKey
    FUSHFOGORKZNNQ-UHFFFAOYSA-N
    InChI
    1S/C21H19N3O3/c1-26-11-12-27-17-9-7-15(8-10-17)18-13-24(16-5-3-2-4-6-16)20-19(18)21(25)23-14-22-20/h2-10,13-14H,11-12H2,1H3,(H,22,23,25)
    Synonyms
    4H-​Pyrrolo[2,​3-​d]​pyrimidin-​4-​one,3,​7-​dihydro-​5-​[4-​(2-​methoxyethoxy)​phenyl]​-​7-​phenyl-
  5. DMX-5084
    CAS: 2306178-56-1 분자식: C21H19N3O3 분자량: 361.39
    ● 재고 있음 — 미국 항목 #: D412287
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    IUPAC 이름
    5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4-one
    SMILES
    COCCOC1=CC=C(C=C1)C2=CN(C3=C2C(=O)NC=N3)C4=CC=CC=C4
    InChIKey
    FUSHFOGORKZNNQ-UHFFFAOYSA-N
    InChI
    1S/C21H19N3O3/c1-26-11-12-27-17-9-7-15(8-10-17)18-13-24(16-5-3-2-4-6-16)20-19(18)21(25)23-14-22-20/h2-10,13-14H,11-12H2,1H3,(H,22,23,25)
    Synonyms
    4H-​Pyrrolo[2,​3-​d]​pyrimidin-​4-​one,3,​7-​dihydro-​5-​[4-​(2-​methoxyethoxy)​phenyl]​-​7-​phenyl-
  6. NG25, Inhibitor of C-terminal Src kinase;Inhibitor of LYN proto-oncogene; Src family tyrosine kinase;Inhibitor of mitogen-activated protein kinase kinase kinase 7;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 2;Inhibitor of SRC proto-oncoge
    CAS: 1315355-93-1 EC 번호: 110-114-3 분자식: C29H30F3N5O2 분자량: 537.58
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● 재고 있음 — 미국 항목 #: N421221
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    IUPAC 이름
    N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
    SMILES
    CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=C5C=CNC5=NC=C4)C(F)(F)F
    InChIKey
    SMPGEBOIKULBCT-UHFFFAOYSA-N
    InChI
    1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-1show more
    Synonyms
    AC-35824 | Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]py...
  7. NCB-0846
    CAS: 1792999-26-8 분자식: C21H21N5O2 분자량: 375.42
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ◐ .주문제작 · 8~12주 항목 #: N413998
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    IUPAC 이름
    4-[2-(3H-benzimidazol-5-ylamino)quinazolin-8-yl]oxycyclohexan-1-ol
    SMILES
    C1CC(CCC1O)OC2=CC=CC3=CN=C(N=C32)NC4=CC5=C(C=C4)N=CN5
    InChIKey
    FYWRWBSYRGSWIQ-UHFFFAOYSA-N
    InChI
    1S/C21H21N5O2/c27-15-5-7-16(8-6-15)28-19-3-1-2-13-11-22-21(26-20(13)19)25-14-4-9-17-18(10-14)24-12-23-17/h1-4,9-12,15-16,27H,5-8H2,(H,23,24)(H,22,25,2show more
    Synonyms
    Cyclohexanol,4-​[[2-​(1H-​benzimidazol-​6-​ylamino)​-​8-​quinazolinyl]​oxy]​-​,cis- | cis-4-((2-((1H-Benzo[d]imidazol...
  8. PF-6260933
    CAS: 1811510-56-1 PubChem CID: 118701008 분자식: C16H13ClN4 분자량: 296.75
    10mM in DMSO
    ● 재고 있음 — 미국 항목 #: P422224
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    IUPAC 이름
    5-(6-aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine
    SMILES
    C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl
    InChIKey
    KHPCIHZXOGHCLY-UHFFFAOYSA-N
    InChI
    1S/C16H13ClN4/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11/h1-9H,(H2,18,20)(H2,19,21)
    Synonyms
    PF-06260933[3,​3'-​Bipyridine]​-​6,​6'-​diamine,5-​(4-​chlorophenyl)​-
  9. PF-6260933
    CAS: 1811510-56-1 PubChem CID: 118701008 분자식: C16H13ClN4 분자량: 296.75
    ● 재고 있음 — 미국 항목 #: P413486
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    IUPAC 이름
    5-(6-aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine
    SMILES
    C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl
    InChIKey
    KHPCIHZXOGHCLY-UHFFFAOYSA-N
    InChI
    1S/C16H13ClN4/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11/h1-9H,(H2,18,20)(H2,19,21)
    Synonyms
    PF-06260933[3,​3'-​Bipyridine]​-​6,​6'-​diamine,5-​(4-​chlorophenyl)​-
  10. GNE-495
    CAS: 1449277-10-4 PubChem CID: 89730041 분자식: C22H20FN5O2 분자량: 405.42
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ◐ .주문제작 · 8~12주 항목 #: G646842
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    IUPAC 이름
    8-amino-N-[1-(cyclopropanecarbonyl)azetidin-3-yl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide
    SMILES
    C1CC1C(=O)N2CC(C2)NC(=O)C3=CN=C(C4=C3C=CC(=N4)C5=CC(=CC=C5)F)N
    InChIKey
    FYXCIBJXJYBWPX-UHFFFAOYSA-N
    InChI
    1S/C22H20FN5O2/c23-14-3-1-2-13(8-14)18-7-6-16-17(9-25-20(24)19(16)27-18)21(29)26-15-10-28(11-15)22(30)12-4-5-12/h1-3,6-9,12,15H,4-5,10-11H2,(H2,24,25)show more
    Synonyms
    8-Amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide
  11. TAK1/MAP4K2 inhibitor 1
    CAS: 1315330-11-0 PubChem CID: 71254032 분자식: C29H31F3N6O2 분자량: 552.59
    ◐ .주문제작 · 8~12주 항목 #: T648184
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    IUPAC 이름
    N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]benzamide
    SMILES
    CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=NC=NC5=C4C=C(N5)C)C(F)(F)F
    InChIKey
    RWNAOXLCVXJMGM-UHFFFAOYSA-N
    InChI
    1S/C29H31F3N6O2/c1-4-37-9-11-38(12-10-37)16-21-7-8-22(15-24(21)29(30,31)32)36-27(39)20-6-5-18(2)25(14-20)40-28-23-13-19(3)35-26(23)33-17-34-28/h5-8,13show more
    Synonyms
    AKOS016012030 | n-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methyl-3-((6-methyl-7h-pyrrolo[2,3-...
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자주 묻는 질문

What can I find under MAP4K?
This listing collects compounds associated with MAP4K within our MAPK/ERK Pathway area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for MAP4K?
Consider the reported potency of each MAP4K compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for MAP4K compounds?
Each MAP4K product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search MAP4K compounds by activity or structure?
Yes. Filter the MAP4K listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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