Meloxicam - Moligand™, 10mM in DMSO , Inhibitor of COX-1;Inhibitor of COX-2, CAS No.71125-38-7, Inhibitor of COX-1;Inhibitor of COX-2

CAS: 71125-38-7 Cat. No.: M408223 분자식: C₁₄H₁₃N₃O₄S₂ 분자량: 351.4 EC 번호: 615-253-8

등급 & 순도 Moligand™, 10mM in DMSO

Synonyms

4-​hydroxy-​2-​methyl-​N-​(5-​methyl-​2-​thiazolyl)​-​1,​1-​dioxide-2H-​1,​2-​benzothiazine-​3-​carboxamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Meloxicam Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.
In vitro

Meloxicam significantly reduces HCA-7 and Moser-S colony size. Meloxicam significantly inhibits HCA-7 colony and tumor growth but has no effect on the growth of the COX-2 negative HCT-116 cells. Meloxicam inhibits PGE(2) production, proliferation and invasiveness especially in MG-63 cells, which express relatively high levels of COX-2. Meloxicam causes apoptosis and upregulates Bax mRNA and protein in MG-63 cell culture.

In vivo

Meloxicam suppresses LM-8 tumor growth and lung metastasis in vivo mouse model. Meloxicam causes a significant reduction in lameness at post injection hour (PIH) 8 and 24 and tends to reduce effusion in horse. Meloxicam significantly suppresses synovial fluid (SF) prostaglandin E2 and substance P release at PIH 8 and bradykinin at PIH 24 compared to placebo treatment in horse. Meloxicam reduces general MMP activity at PIH 8 and 24 in horse. Meloxicam- or flunixin-treated horses has improved postoperative pain scores and clinical variables, compared with SS-treated horses. Meloxicam results in high numbers of neutrophils in ischemia-injured tissue of horse. Meloxicam administration significantly suppresses PGE2 concentrations in blood and synovial fluid at days 7 and 21, but has no effect on concentrations of TXB2 in blood or PGE2 in gastric mucosa in dogs.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

사양

동의어

4-​hydroxy-​2-​methyl-​N-​(5-​methyl-​2-​thiazolyl)​-​1,​1-​dioxide-2H-​1,​2-​benzothiazine-​3-​carboxamide

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Meloxicam is a selective COX inhibitor, used to relieve pain and fever effects.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

Inhibitor of COX-1;Inhibitor of COX-2

이름과 식별자

이성체 SMILES

CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O

RTECS

DL0702000

UN 번호

2811

포장 그룹

III

분자량

351.4

Reaxy-Rn

5886369

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5886369&ln=

관련 대상(인간)

PTGS1 Tclin Prostaglandin G/H synthase 1 (1 Activities)

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (6 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 녹는점(°C): 255°C