2-Methoxyestradiol (2-MeOE2) - Moligand™, ≥98% , Agonist of GPER, CAS No.362-07-2, Agonist of GPER

CAS: 362-07-2 Cat. No.: M125960 Molecular Weight: 302.41 EC Number: 636-846-8

2-Methoxyestradiol (2-MeOE2) - Moligand™, ≥98% CAS No(362-07-2) by Aladdin Scientific

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AVAILABLE TO ORDER

Synonyms

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Documents & Articles Citations of This Product References Solution Calculators Reviews

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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

2-Methoxyestradiol (2-MeOE2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.
A disruptor of microtubule function and HIF-1 inhibitor

Specifications

Synonyms

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

2-methoxyestradiol (2ME2) is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.2-Methoxyestradiol is an endogenous estrogen metabolite with low affinity for

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of GPER

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

Pubchem Sid	504754070
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504754070
Canonical Smiles	CC12CCC3C(C1CCC2O)CCC4=CC(=C(C=C34)OC)O
IUPAC Name	(8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
InChIKey	CQOQDQWUFQDJMK-SSTWWWIQSA-N
INCHI	1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1
Isomeric SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=C(C=C34)OC)O
WGK Germany	3
RTECS	KG7537500
Molecular Weight	302.41
Reaxy-Rn	1992189
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1992189&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Steroids and steroid derivatives
    - Subclass Estrane steroids

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Steroids and steroid derivatives
Subclass	Estrane steroids
Intermediate Tree Nodes	Not available
Direct Parent	Estrogens and derivatives
Alternative Parents	3-hydroxysteroids 17-hydroxysteroids Phenanthrenes and derivatives Tetralins Anisoles Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids Secondary alcohols Cyclic alcohols and derivatives Hydrocarbon derivatives
Molecular Framework	Aromatic homopolycyclic compounds
Substituents	Estrogen-skeleton - 3-hydroxysteroid - 17-hydroxysteroid - Hydroxysteroid - Phenanthrene - Tetralin - Anisole - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - Benzenoid - Cyclic alcohol - Secondary alcohol - Ether - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Alcohol - Aromatic homopolycyclic compound
Description	This compound belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane.
External Descriptors	C18 steroids (estrogens) and derivatives
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

SHBG Tchem Sex hormone-binding globulin (1 Activities)

Discover Target: SHBG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPER1 Tchem G-protein coupled estrogen receptor 1 (0 Activities)

Discover Target: GPER1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP19A1 Tclin Cytochrome P450 19A1 (6099 Activities)

Discover Target: CYP19A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ESR2 Tclin Estrogen receptor beta (9272 Activities)

Discover Target: ESR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1B1 Tchem Cytochrome P450 1B1 (1148 Activities)

Discover Target: CYP1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

Discover Target: GBA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

Discover Target: GAA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)

Discover Target: CYP1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)

Discover Target: MTOR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Lot Number	Certificate Type	Date	Item
L2409488	Certificate of Analysis	Sep 01, 2026	M125960
L2409487	Certificate of Analysis	Sep 01, 2026	M125960
L2409486	Certificate of Analysis	Sep 01, 2026	M125960
L2409485	Certificate of Analysis	Sep 01, 2026	M125960
L2409484	Certificate of Analysis	Sep 01, 2026	M125960
L2409483	Certificate of Analysis	Sep 01, 2026	M125960
B2421544	Certificate of Analysis	Dec 10, 2025	M125960
B2421547	Certificate of Analysis	Dec 10, 2025	M125960
I2419549	Certificate of Analysis	Sep 06, 2024	M125960
I2419566	Certificate of Analysis	Sep 06, 2024	M125960
I2419568	Certificate of Analysis	Sep 06, 2024	M125960
I2419569	Certificate of Analysis	Sep 06, 2024	M125960
G2411666	Certificate of Analysis	May 20, 2024	M125960
G2411668	Certificate of Analysis	May 20, 2024	M125960
G2411664	Certificate of Analysis	May 20, 2024	M125960
G2411662	Certificate of Analysis	May 20, 2024	M125960
B2421543	Certificate of Analysis	Jan 31, 2024	M125960
B2421545	Certificate of Analysis	Jan 31, 2024	M125960
B2421546	Certificate of Analysis	Jan 31, 2024	M125960
B2421556	Certificate of Analysis	Jan 31, 2024	M125960
K2209731	Certificate of Analysis	Oct 27, 2022	M125960
K2209723	Certificate of Analysis	Oct 27, 2022	M125960
K2209722	Certificate of Analysis	Oct 27, 2022	M125960
K2209721	Certificate of Analysis	Oct 27, 2022	M125960
K2209699	Certificate of Analysis	Oct 27, 2022	M125960
I2307032	Certificate of Analysis	Oct 27, 2022	M125960
H2329099	Certificate of Analysis	Oct 27, 2022	M125960

Solubility	Soluble in DMSO (10 mg/mL), ethanol (10 mg/mL), chloroform, ethanol (1 mg/ml), and 1:1DMF:PBS(pH7.2) (0.5 mg/ml). Insoluble in water.
Specific Rotation[α]	107° (C=0.5,THF)
Melt Point(°C)	187 °C
Molecular Weight	302.400 g/mol
XLogP3	4.000
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	302.188 Da
Monoisotopic Mass	302.188 Da
Topological Polar Surface Area	49.700 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	425.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

2-Methoxyestradiol (2-MeOE2) - Moligand™, ≥98% , Agonist of GPER, CAS No.362-07-2, Agonist of GPER

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

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📚 Citations by Application

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