10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
3-Deazaadenosine hydrochloride 3-Deazaadenosine HCl (3-DZA, c3Ado) is a potent inhibitor of S-adenosylhomocysteine hydrolase with Ki of 3.9 µM. 3-Deazaadenosine HCl inhibits bacterial lipopolysaccharide-induced transcription of TNF-α and IL-1β . 3-Deazaadenosine HCl inhibits the transcriptional activity of NF-κB , prevents FCS-induced Ras carboxyl methylation and reduces FCS-induced ERK1/2 and Akt phosphorylation. 3-Deazaadenosine HCl has anti-inflammatory, anti-proliferative and anti-HIV activities.
Targets
S-adenosylhomocysteine hydrolase (Cell-free assay) 3.9 μM(Ki)
| ALogP | -1.07 |
|---|---|
| HBD Count | 4 |
| Rotatable Bond | 2 |
| Pubchem Sid | 528759245 |
|---|---|
| Canonical Smiles | C1=CN=C(C2=C1N(C=N2)C3C(C(C(O3)CO)O)O)N.Cl |
| IUPAC Name | (2R,3R,4S,5R)-2-(4-aminoimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol;hydrochloride |
| InChIKey | WQRKYGAAEYXMKZ-RPWKAPHTSA-N |
| INCHI | 1S/C11H14N4O4.ClH/c12-10-7-5(1-2-13-10)15(4-14-7)11-9(18)8(17)6(3-16)19-11;/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13);1H/t6-,8-,9-,11-;/m1./s1 |
| PubChem CID | 134828261 |
| Molecular Weight | 302.71 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F2417498 | Certificate of Analysis | May 11, 2026 | D426445 |
| DMSO(mg / mL) Max Solubility | 60 |
|---|---|
| DMSO(mM) Max Solubility | 198.209507449374 |
| Water(mg / mL) Max Solubility | 60 |
| Water(mM) Max Solubility | 198.209507449374 |
| Molecular Weight | 302.710 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 2 |
| Exact Mass | 302.078 Da |
| Monoisotopic Mass | 302.078 Da |
| Topological Polar Surface Area | 127.000 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 334.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
