PROTAC Linkers

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  1. Azido-PEG2-C2-acid
    CAS: 1312309-63-9 Formula: C7H13N3O4 Molecular Weight: 203.20
    Liquid ≥97%
    ● In Stock — US Item #: A412755
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    Technical Identifiers
    IUPAC Name
    3-[2-(2-azidoethoxy)ethoxy]propanoic acid
    SMILES
    C(COCCOCCN=[N+]=[N-])C(=O)O
    InChIKey
    IEHDSRSXQAOLJT-UHFFFAOYSA-N
    InChI
    1S/C7H13N3O4/c8-10-9-2-4-14-6-5-13-3-1-7(11)12/h1-6H2,(H,11,12)
    Synonyms
    3-(2-(2-azidoethoxy)ethoxy)propanoic acid | N3-PEG2-CH2CH2COOH | Azido-PEG2-acid | Azido-PEG2-propionic acid | 9-Azid...
  2. O-(2-[2-(Aminooxy)ethoxy]ethyl)hydroxylamine
    CAS: 93460-33-4 Formula: C4H12N2O3 Molecular Weight: 136.15
    Liquid ≥95%
    ◐ .Made to order · 8–12 wks Item #: B596552
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    Technical Identifiers
    IUPAC Name
    O-[2-(2-aminooxyethoxy)ethyl]hydroxylamine
    SMILES
    C(CON)OCCON
    InChIKey
    ZESQVNWRUDEXNZ-UHFFFAOYSA-N
    InChI
    1S/C4H12N2O3/c5-8-3-1-7-2-4-9-6/h1-6H2
    Synonyms
    Bis-aminooxy-PEG1
  3. Ms-PEG5-Ms
    CAS: 55400-73-2 Formula: C10H22O9S2 Molecular Weight: 350.41
    Liquid ≥98%
    ◐ .Made to order · 8–12 wks Item #: M597197
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    Technical Identifiers
    IUPAC Name
    2-[2-[2-(2-methylsulfonyloxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate
    SMILES
    CS(=O)(=O)OCCOCCOCCOCCOS(=O)(=O)C
    InChIKey
    GKMDADHKHXRPPF-UHFFFAOYSA-N
    InChI
    1S/C10H22O9S2/c1-20(11,12)18-9-7-16-5-3-15-4-6-17-8-10-19-21(2,13)14/h3-10H2,1-2H3
    Synonyms
    13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl methanesulfonate | 1,11-Bis(methanesulfonyloxy)-3,6,9-trioxandec...
  4. THP-PEG4-OH
    CAS: 128660-97-9 PubChem CID: 10731287 Formula: C13H26O6 Molecular Weight: 278.34
    Liquid ≥98%
    ◐ .Made to order · 8–12 wks Item #: T596768
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    Technical Identifiers
    IUPAC Name
    2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethanol
    SMILES
    C1CCOC(C1)OCCOCCOCCOCCO
    InChIKey
    XUTYVMRXVARJFT-UHFFFAOYSA-N
    InChI
    1S/C13H26O6/c14-4-6-15-7-8-16-9-10-17-11-12-19-13-3-1-2-5-18-13/h13-14H,1-12H2
    Synonyms
    THP-PEG5 | 2-(2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)ethan-1-ol
  5. Amino-PEG5-alcohol
    CAS: 34188-11-9 EC Number: 979-259-5 PubChem CID: 21737076 Formula: C10H23NO5 Molecular Weight: 237.29
    ● In Stock — US Item #: A595269
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    Technical Identifiers
    IUPAC Name
    2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanol
    SMILES
    C(COCCOCCOCCOCCO)N
    InChIKey
    DEOUHEFHTMMUCM-UHFFFAOYSA-N
    InChI
    1S/C10H23NO5/c11-1-3-13-5-7-15-9-10-16-8-6-14-4-2-12/h12H,1-11H2
    Synonyms
    14-Amino-3,6,9,12-tetraoxatetradecan-1-ol | NH2-PEG5-OH
  6. 2-(2-(3-Aminopropoxy)ethoxy)ethan-1-ol
    CAS: 112-33-4 EC Number: 203-960-0 PubChem CID: 66985 Formula: C7H17NO3 Molecular Weight: 163.21
    Liquid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ◐ .Made to order · 8–12 wks Item #: E694165
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    Technical Identifiers
    IUPAC Name
    2-[2-(3-aminopropoxy)ethoxy]ethanol
    SMILES
    C(CN)COCCOCCO
    InChIKey
    DCZMLYRQHBZWLZ-UHFFFAOYSA-N
    InChI
    1S/C7H17NO3/c8-2-1-4-10-6-7-11-5-3-9/h9H,1-8H2
    Synonyms
    OH-PEG2-C3-NH2
  7. 6-Chlorohexanal
    CAS: 52387-36-7 EC Number: 965-129-5 Formula: C6H11ClO Molecular Weight: 134.60
    Liquid ≥95%
    ◐ .Made to order · 8–12 wks Item #: C698589
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    Technical Identifiers
    IUPAC Name
    6-chlorohexanal
    SMILES
    C(CCC=O)CCCl
    InChIKey
    GVIQYWPEJQUXLX-UHFFFAOYSA-N
    InChI
    1S/C6H11ClO/c7-5-3-1-2-4-6-8/h6H,1-5H2
  8. 2-(2-(2-Aminoethoxy)ethoxy)acetic acid hydrochloride
    CAS: 134979-01-4 EC Number: 816-400-0 PubChem CID: 45789699 Formula: C6H14ClNO4 Molecular Weight: 199.63
    Solid ≥97%
    ◐ .Made to order · 8–12 wks Item #: E732591
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    Technical Identifiers
    IUPAC Name
    2-[2-(2-aminoethoxy)ethoxy]acetic acid;hydrochloride
    SMILES
    C(COCCOCC(=O)O)N.Cl
    InChIKey
    NGPFHPADAGAUDR-UHFFFAOYSA-N
    InChI
    1S/C6H13NO4.ClH/c7-1-2-10-3-4-11-5-6(8)9;/h1-5,7H2,(H,8,9);1H
    Synonyms
    [2-(2-aminoethoxy)ethoxy]acetic acid hydrochloride | H2N-PEG2-CH2COOH hydrochloride | AEEA.HCl | H-AEEA-OH.HCl
  9. 1-Boc-4-(3-bromopropyl)piperidine
    CAS: 164149-27-3 EC Number: 986-198-8 PubChem CID: 18409081 Formula: C13H24BrNO2 Molecular Weight: 306.25
    ◐ .Made to order · 8–12 wks Item #: T729236
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    Technical Identifiers
    IUPAC Name
    tert-butyl 4-(3-bromopropyl)piperidine-1-carboxylate
    SMILES
    CC(C)(C)OC(=O)N1CCC(CC1)CCCBr
    InChIKey
    ANKJSMCUWZFYKF-UHFFFAOYSA-N
    InChI
    1S/C13H24BrNO2/c1-13(2,3)17-12(16)15-9-6-11(7-10-15)5-4-8-14/h11H,4-10H2,1-3H3
    Synonyms
    tert-butyl 4-(3-bromopropyl)piperidine-1-carboxylate
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

What should I consider when selecting PROTAC Linkers?
When selecting PROTAC Linkers, consider the coupling chemistry available on both partners, whether the linker needs to be cleavable, and how length and hydrophilicity will affect solubility of the final conjugate. Test a short series rather than committing to one geometry.
What does PROTAC Linkers cover?
PROTAC Linkers is a top-level listing in our catalogue. Use the filters and search on the listing page to narrow by the attributes that matter for your work, or browse the neighbouring categories from the main navigation.
Which quality data should I check for PROTAC Linkers?
Review HPLC purity and MS identity for the PROTAC Linkers lot and, where relevant, the polydispersity index, plus residual solvent and water content. For reactive esters and similar handles, the retest date matters as much as the purity figure. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I find PROTAC Linkers by reactive group or linker length?
Yes — filter PROTAC Linkers by reactive handle, linker length or PEG units, and cleavability, and search by CAS number or SMILES for exact structures. Custom linkers and bulk quantities: [email protected].

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