AMI 1 - ≥98% , CAS No.20324-87-2

CAS: 20324-87-2 Cat. No.: A275769 Summenformel: C₂₁H₁₄N₂Na₂O₉S₂ Molekulargewicht: 548.45 EG-Nummer: 243-735-4

GRADE & PURITY ≥98%

Synonyms

DTXSID80889678 | Dinatrium-4-Hydroxy-7-{[(5-hydroxy-7-sulfonatonaphthalin-2-yl)carbamoyl]amino}naphthale yl)carbamoyl]amino}naphthalin-2-sulfonat | FT-0655839 | AMI-1 Dinatriumsalz | BCP15937 | AMI1 | AMI-1 | 2-Naphthalinsulfonsäure, 7,7'-(carbonyldii

Storage

Vor Licht geschützt, bei -20°C aufbewahren, getrocknet

Shipped In

Eistruhe + Eispads

Übersicht

Bei -20°C lagern. Es ist wichtig zu beachten, dass dieses Produkt als lichtempfindlich eingestuft wird. Im Dunkeln lagern. Unter austrocknenden Bedingungen lagern.

Specifications

Synonyme

DTXSID80889678 | Dinatrium-4-Hydroxy-7-{[(5-hydroxy-7-sulfonatonaphthalin-2-yl)carbamoyl]amino}naphthale yl)carbamoyl]amino}naphthalin-2-sulfonat | FT-0655839 | AMI-1 Dinatriumsalz | BCP15937 | AMI1 | AMI-1 | 2-Naphthalinsulfonsäure, 7,7'-(carbonyldii

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

Protein-Arginin-N-Methyltransferasen (PRMTs) sind an posttranslationalen Modifikationen beteiligt, die mit dem Proteinverkehr, der Signaltransduktion und der Transkriptionsregulierung zusammenhängen. AMI-1 hemmt die Aktivität der Lysin-Methyltransferase n

Storage

Vor Licht geschützt, bei -20°C aufbewahren, getrocknet

Verschickt in

Eistruhe + Eispads

Hinweis

Wenn möglich, sollten Sie die Lösungen noch am selben Tag zubereiten und verwenden. Wenn Sie jedoch Stammlösungen im Voraus herstellen müssen, empfehlen wir Ihnen, die Lösung als Aliquote in dicht verschlossenen Fläschchen bei -20 °C zu lagern. Diese sind in der Regel bis zu einem Monat haltbar. Vor der Verwendung und vor dem Öffnen des Fläschchens empfehlen wir, das Produkt mindestens 1 Stunde lang auf Raumtemperatur kommen zu lassen. Benötigen Sie weitere Ratschläge zur Löslichkeit, Verwendung und Handhabung? Besuchen Sie unsere Seite mit den häufig gestellten Fragen (FAQ) für weitere Informationen.

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 504755943
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504755943
• Kanonisches Lächeln: C1=CC2=C(C=C(C=C2C=C1NC(=O)NC3=CC4=CC(=CC(=C4C=C3)O)S(=O)(=O)[O-])S(=O)(=O)[O-])O.[Na+].[Na+]
• IUPAC Name: disodium;4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate
• InChIKey: MOUNHKKCIGVIDI-UHFFFAOYSA-L
• INCHI: 1S/C21H16N2O9S2.2Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;/q;2*+1/p-2
• Isomere SMILES: C1=CC2=C(C=C(C=C2C=C1NC(=O)NC3=CC4=CC(=CC(=C4C=C3)O)S(=O)(=O)[O-])S(=O)(=O)[O-])O.[Na+].[Na+]
• Molekulargewicht: 548.45
• Reaxy-Rn: 9464569
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9464569&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Naphthalenes
      • Subclass Naphthalene sulfonic acids and derivatives
        • Ebene5 Naphthalene sulfonates
          • Ebene6 2-naphthalene sulfonates

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Naphthalenes
• Subclass: Naphthalene sulfonic acids and derivatives
• Intermediate Tree Nodes: Naphthalene sulfonates
• Direct Parent: 2-naphthalene sulfonates
• Alternative Parents: 2-naphthalene sulfonic acids and derivatives Naphthols and derivatives 1-sulfo,2-unsubstituted aromatic compounds 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Sulfonyls Organosulfonic acids Ureas Organopnictogen compounds Organonitrogen compounds Organic sodium salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: 2-naphthalene sulfonate - 2-naphthalene sulfonic acid or derivatives - 1-naphthol - Arylsulfonic acid or derivatives - 1-sulfo,2-unsubstituted aromatic compound - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Sulfonyl - Carbonic acid derivative - Urea - Organic alkali metal salt - Organic nitrogen compound - Organic salt - Organic sodium salt - Hydrocarbon derivative - Organic oxide - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Aromatic homopolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as 2-naphthalene sulfonates. These are organic aromatic compounds that contain a naphthalene moiety that carries a sulfonic acid group at the 2-position. Naphthalene is a bicyclic compound that is made up of two fused benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

A-375 (9258 Activities)

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Daoy (570 Activities)

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MCF7 (126967 Activities)

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SH-SY5Y (11521 Activities)

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HepG2 (196354 Activities)

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SIRT1 Tchem NAD-dependent deacetylase sirtuin 1 (3505 Activities)

Discover Target: SIRT1

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LAPC4 (305 Activities)

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PRMT1 Tchem Protein-arginine N-methyltransferase 1 (867 Activities)

Discover Target: PRMT1

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PRMT5 Tchem Protein arginine N-methyltransferase 5 (1273 Activities)

Discover Target: PRMT5

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Zugehörige Ziele (nicht menschlich)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in water to 100 mM and in DMSO to 100 mM
• Empfindlichkeit: light sensitive
• Molekulargewicht: 548.500 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 2
• Exact Mass: 547.994 Da
• Monoisotopic Mass: 547.994 Da
• Topological Polar Surface Area: 213.000 Ų
• Heavy Atom Count: 36
• Formal Charge: 0
• Complexity: 859.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3