Blasticidin-S - HCl - 10mM in Water , CAS No.3513-03-9

CAS: 3513-03-9 Cat. No.: B423562 Molecular Weight: 458.9 EC Number: 609-067-6 PubChem CID: 75412545

GRADE & PURITY 10mM in Water

Synonyms

(2S,3S,6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride | blasticidin S HCl | (2S,3S,6R)-6-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-[(3S)-3-amino-5-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Blasticidin S Hydrochloride belongs to a group of cytosine amino nucleoside antibiotics. The compound Blasticidin S has a wide spectrum of antimicrobial activity and acts on prokaryotic and eukaryotic organisms by inhibiting protein synthesis.
Blasticidin-S is a commonly used tool in genetic engineering. Blasticidin-S inhibits protein synthesis in both prokaryotic and eukaryotic cells. It is common method to include a gene for Blasticidin S resistance into the plasmid being inserted into the target cells, and then to apply Blasticidin S to the culture to select these cells that have acquired that immunity. The Blasticidin S gene resistance gene (BSR), found in Bacillus cereus K55-S1, has been used in multiple studies for its use as a selective compound. Another antibiotic that belongs to the family of nucleosides is puromycin

Specifications

Synonyms

(2S, 3S, 6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3, 6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride | blasticidin S HCl | (2S, 3S, 6R)-6-(4-amino-2-oxo-1, 2-dihydropyrimidin-1-yl)-3-[(3S)-3-amino-5-

Specifications & Purity

10mM in Water

Biochemical and Physiological Mechanisms

Blasticidin S Hydrochloride, like puromycin, belongs to a group of cytosine amino nucleoside antibiotics. The compound blasticidin S has a wide spectrum of antimicrobial activity and acts on prokaryotic and eukaryotic organisms by inhibiting protein synth

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CN(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl
• IUPAC Name: (2S,3S,6R)-3-[[(3S)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid;hydrochloride
• InChIKey: YQXYQOXRCNEATG-NMQKUDMSSA-N
• INCHI: 1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10-,13+,14-;/m0./s1
• Isomeric SMILES: CN(CC[C@@H](CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl
• WGK Germany: 2
• PubChem CID: 75412545
• Molecular Weight: 458.9

Chemical and Physical Properties

• Sensitivity: Moisture sensitive
• Refractive Index: 1.71
• Boil Point(°C): 772.1 °C at 760 mmHg
• Molecular Weight: 458.900 g/mol
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 458.179 Da
• Monoisotopic Mass: 458.179 Da
• Topological Polar Surface Area: 213.000 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 795.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Xinyi Song, Haipeng Rao, Chunchun Huang, Miaoling Huang, Ying Ma, Jingyu Xin, Jiajia Hou, Zhigang Hu, Lingfeng He, Feiyan Pan, Lingdong Yang, Zhigang Guo.  (2025)  P4HB, a novel succinated protein, is essential for fumarate-induced cancer metastasis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40318732] [10.1016/j.ijbiomac.2025.143885]