cGAMP sodium salt - ≥99% , CAS No.849214-04-6(freeacid)

CAS: 849214-04-6(freeacid) Cat. No.: C413869 Summenformel: C₂₀H₂₄N₁₀O₁₃ P₂·xNa+ Molekulargewicht: 674.41 (free acid basis)

GRADE & PURITY ≥99%

Synonyms

3',3'-cGAMP

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Information

3',3'-cGAMP 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING) , thereby inducing an antiviral state and the secretion of type I IFNs.

Targets

STING

In vivo

Sublingual immunization of mice with Bacillus anthracis protective antigen (PA) and the STING ligand 3′3′-cGAMP promotes PA-specific serum IgG Ab responses of the same magnitude as those induced after immunization with PA and the experimental adjuvants cholera toxin (CT). 3′3′-cGAMP also promotes serum anti-PA IgA and IgA-producing cells in the bone marrow. Furthermore, the saliva of mice immunized with 3′3′-cGAMP exhibits similar levels of PA-specific IgA Abs as groups immunized with CT as adjuvant. The adjuvant activity of 3′3′-cGAMP is associated with mixed Th1, Th2, and Th17 responses. 3′3′-cGAMP also induces rapid IFN-β and IL-10 responses in sublingual tissues and cervical lymph nodes, and TGF-β responses in the cervical lymph nodes, which can contribute to promoting IgA responses after sublingual immunization.

Product description

cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators

Product application
cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay

Specifications

Synonyme

3',3'-cGAMP

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥99%

Namen und Kennungen

Molekulargewicht

674.41 (free acid basis)

Zugehörige Ziele (menschlich)

TMEM173 Tchem Stimulator of interferon genes protein (0 Activities)

Discover Target: TMEM173

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro Water: 100 mg/mL (148.72 mM); DMSO: 20 mg/mL (29.74 mM); Ethanol: Insoluble

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 849214-04-6(freeacid), the molecular formula is C20H24N10O13 P2·xNa+, and the molecular weight is 674.41 (free acid basis) g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.