Combretastatin A4 - Moligand™, ≥98%(HPLC) , Inhibitor of tubulin beta 3 class III, CAS No.117048-59-6, Inhibitor of tubulin beta 3 class III

CAS: 117048-59-6 Cat. No.: C153431 Molecular Weight: 316.35 EC Number: 631-427-6

2 Citations COA

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Combretastatin A4 - Moligand™, ≥98%(HPLC) CAS No(117048-59-6) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY Moligand™ ? ≥98%(HPLC)

Synonyms

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Size

Status

Price

Qty

5mg

C153431-5mg

$17.90

$26.90
Save $9.00 (33.46%)

25mg

C153431-25mg

8-12 wks(?)

$38.90

$58.90
Save $20.00 (33.96%)

50mg

C153431-50mg

$70.90

$106.90
Save $36.00 (33.68%)

100mg

C153431-100mg

$102.90

$154.90
Save $52.00 (33.57%)

250mg

C153431-250mg

8-12 wks(?)

$185.90

$278.90
Save $93.00 (33.35%)

500mg

C153431-500mg

$334.90

$502.90
Save $168.00 (33.41%)

C153431-1g

$481.90

$722.90
Save $241.00 (33.34%)

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Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Citations of This Product References Solution Calculators Reviews

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Why this grade

Moligand™, ≥98%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms

Specifications & Purity

Moligand™, ≥98%(HPLC)

Biochemical and Physiological Mechanisms

Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of tubulin beta 3 class III

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%(HPLC)

Names and Identifiers

Pubchem Sid	504763647
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504763647
Canonical Smiles	COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O
IUPAC Name	2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
InChIKey	HVXBOLULGPECHP-WAYWQWQTSA-N
INCHI	1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
Isomeric SMILES	COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)O
WGK Germany	2
Molecular Weight	316.35
Reaxy-Rn	11100193
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11100193&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Stilbenes

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Stilbenes
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Stilbenes
Alternative Parents	Methoxyphenols Styrenes Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Stilbene - Methoxyphenol - Phenoxy compound - Anisole - Methoxybenzene - Styrene - Phenol ether - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - Phenol - Benzenoid - Monocyclic benzene moiety - Ether - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

TUBB1 Tclin Tubulin beta-1 chain (1 Activities)

Discover Target: TUBB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCB1 Tchem Multidrug resistance protein 1 (2 Activities)

Discover Target: ABCB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TUBB3 Tclin Tubulin beta-3 chain (4 Activities)

Discover Target: TUBB3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

Discover Target: ABL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 Activities)

Discover Target: PDGFRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FGFR1 Tclin Fibroblast growth factor receptor 1 (9149 Activities)

Discover Target: FGFR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)

Discover Target: SRC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TUBB3 Tclin Tubulin beta-3 chain (22 Activities)

Discover Target: TUBB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TUBB1 Tclin Tubulin beta-1 chain (182 Activities)

Discover Target: TUBB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

1A9 (618 Activities)

Lot Number	Certificate Type	Date	Item
J2109166	Certificate of Analysis	Jul 10, 2025	C153431
J2109167	Certificate of Analysis	Jul 10, 2025	C153431
J2109168	Certificate of Analysis	Jul 10, 2025	C153431
J2109169	Certificate of Analysis	Jul 10, 2025	C153431
L2423050	Certificate of Analysis	Apr 23, 2024	C153431
L2423569	Certificate of Analysis	Apr 23, 2024	C153431
L1910060	Certificate of Analysis	Sep 08, 2023	C153431
C1911066	Certificate of Analysis	Aug 04, 2023	C153431
J1928142	Certificate of Analysis	Aug 04, 2023	C153431
A2616008	Certificate of Analysis	Jul 15, 2022	C153431
D2525066	Certificate of Analysis	Jul 15, 2022	C153431
H2321109	Certificate of Analysis	Jul 15, 2022	C153431
H2501104	Certificate of Analysis	Jul 15, 2022	C153431
I2222535	Certificate of Analysis	Jul 15, 2022	C153431
I2222643	Certificate of Analysis	Jul 15, 2022	C153431
I2222644	Certificate of Analysis	Jul 15, 2022	C153431

Solubility	DMSO: >10 mg/mL
Sensitivity	Light sensitive
Melt Point(°C)	83 °C
Molecular Weight	316.300 g/mol
XLogP3	3.700
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	316.131 Da
Monoisotopic Mass	316.131 Da
Topological Polar Surface Area	57.200 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	358.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Combretastatin A4 - Moligand™, ≥98%(HPLC) , Inhibitor of tubulin beta 3 class III, CAS No.117048-59-6, Inhibitor of tubulin beta 3 class III

Why this grade

Storage & shipping

Quality documents

Literature proof

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

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