CVN424 - ≥99% , CAS No.2254706-21-1

CAS: 2254706-21-1 Cat. No.: C649899 Summenformel: C₂₄H₂₉F₂N₅O₃ Molekulargewicht: 473.52 EG-Nummer: 192-146-8 PubChem CID: 137359492

QUALITÄT & REINHEIT ≥99%

Synonyms

XO01711URG | Ethanone, 1-(2-(4-(2,4-difluorophenoxy)-1-piperidinyl)-7,8-dihydro-3-(((3R)-tetrahydro-3-furanyl)amino)pyrido(3,4-b)pyrazin-6(5H)-yl)- | Z3664677849 | MS-28775 | AKOS040759781 | BDBM50582450 | compound 6i [PMID: 33861086] | HY-134661A | SCHEM

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

CVN424 is an orally active and selective GPR6 inverse agonist with a K i of 9.4 nM and an EC 50 of 38 nM. CVN424 is brain-penetrant and has the potential for Parkinson disease research

In Vitro

CVN424 (Compound 6i) has 265 fold and 68 fold selectivities over GPR3 and GPR12. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Ki: 9.4 nM (GPR6), EC50: 38 nM (GPR6)

Spezifikationen

Synonyme

XO01711URG | Ethanone, 1-(2-(4-(2,4-difluorophenoxy)-1-piperidinyl)-7,8-dihydro-3-(((3R)-tetrahydro-3-furanyl)amino)pyrido(3,4-b)pyrazin-6(5H)-yl)- | Z3664677849 | MS-28775 | AKOS040759781 | BDBM50582450 | compound 6i [PMID: 33861086] | HY-134661A | SCHEM

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

CVN424 is an orally active and selective GPR6 inverse agonist with a K i of 9.4 nM and an EC 50 of 38 nM. CVN424 is brain-penetrant and has the potential for Parkinson disease research.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥99%

Namen und Kennungen

Kanonisches Lächeln

CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)NC5CCOC5

IUPAC Name

1-[2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-[[(3R)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone

InChIKey

HSWVJQBEXRKOBZ-QGZVFWFLSA-N

INCHI

1S/C24H29F2N5O3/c1-15(32)31-10-6-20-21(13-31)28-23(27-17-7-11-33-14-17)24(29-20)30-8-4-18(5-9-30)34-22-3-2-16(25)12-19(22)26/h2-3,12,17-18H,4-11,13-14H2,1H3,(H,27,28)/t17-/m1/s1

Isomere SMILES

CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)N[C@@H]5CCOC5

Alternative CAS-Nummer

2254706-21-1

PubChem CID

137359492

Molekulargewicht

473.52

Zugehörige Ziele (menschlich)

GPR6 Tchem G-protein coupled receptor 6 (4 Activities)

Discover Target: GPR6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (2 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

Abcb1b P-glycoprotein 1 (174 Activities)

Discover Target: Abcb1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 62.5 mg/mL (131.99 mM; Need ultrasonic)